施竞超 王利民 王华斌

    [摘要]?目的?研究炎性腸病(inflammatory?bowel?disease，IBD)患者凝血相关指标的变化情况，并评估各指标对炎性肠病活动性的诊断价值。方法?选取2019年1月至2022年12月金华市中心医院收治的228例IBD患者作为IBD组，其中又分为溃疡性结肠炎(ulcerative?colitis，UC)组患者118例，克罗恩病(Crohns?disease，CD)组患者110例。将UC组分为缓解组(n=52)和活动组(n=66)，CD组分为缓解组(n=40)和活动组(n=70)。另选取100名健康成人作为对照组。比较各组的血浆凝血酶原时间(prothrombin?time，PT)、活化部分凝血活酶时间(activated?partial?thromboplastin?time，APTT)、凝血酶时间(thrombin?time，TT)、纤维蛋白原(fibrinogen，FIB)、D-二聚体(D-dimer，D-D)、血小板(platelet，PLT)、平均血小板体积(mean?platelet?volume，MPV)等指标水平。采用受试者操作特征(receiver?operator?characteristic，ROC)曲线评估各参数对疾病活动性的研究价值。结果?UC组和CD组的PT、APTT、FIB、D-D、PLT均高于对照组，TT、MPV均低于对照组，差异均有统计学意义(P[Abstract]?Objective?To?study?the?changes?of?coagulation-related?indicators?in?patients?with?inflammatory?bowel?disease(IBD)，?and?to?evaluate?the?diagnostic?value?of?these?indicators?for?IBD?activity.?Methods?A?total?of?228?patients?with?IBD?admitted?to?Jinhua?Municipal?Central?Hospital?from?January?2019?to?December?2022?were?selected?as?the?IBD?group，?including?118?patients?with?ulcerative?colitis?(UC)?as?the?UC?group?and?110?patients?with?Crohns?disease?(CD)?as?the?CD?group.?The?UC?group?was?divided?into?a?remission?group?(n=52)?and?an?active?group?(n=66) ......