吴国栋 张显玮 叶芸 施如勇 金贝 胡旻

    [摘要]?目的?探讨血清学联合系统超声在孕中期唐氏综合征、三体综合征及神经管畸形胎儿筛查中的应用价值。方法?选取2017年12月至2020年12月孕中期在金华市妇幼保健院接受产前血清学及系统超声检查的单胎孕妇5236例作为研究对象。血清学检测指标包括游离人绒毛膜促性腺激素(free?human?chorionic?gonadotropin，fHCG)、甲胎蛋白(alpha?fetoprotein，AFP)、游离雌三醇(unconjugated?estriol，uE3)，使用软件进行风险值计算，对高风险孕妇行羊膜腔穿刺羊水细胞培养核型分析，对比血清学、超声单项筛查与联合筛查的诊断效能。结果?5236例孕妇经产前诊断出56例先天性缺陷胎儿，发生率1.07%。血清学单项检出阳性288例，阳性率5.50%；超声单项检出阳性116例，阳性率2.22%；血清学联合系统超声检出阳性82例，阳性率1.57%。血清学、超声、血清学联合系统超声筛查的阳性率及真阳性率比较，差异均有统计学意义(P

    [Abstract]?Objective?To?explore?the?application?value?of?serology?combined?with?systemic?ultrasound?in?screening?Down?syndrome，?trisomy?syndrome?and?neural?tube?malformation?fetuses?in?the?second?trimester?of?pregnancy.?Methods?5236?single?pregnant?women?who?underwent?prenatal?serology?and?systemic?ultrasound?examination?in?Jinhua?Maternal?and?Child?Health?Hospital?during?the?second?trimester?of?pregnancy?from?December?2017?to?December?2020?were?selected?as?the?study?subjects.?Serological?indicators?included?free?human?chorionic?gonadotropin?(fHCG) ......