邹瑞瑛 张旭 王瑾 范婉钰 郭俊秀 滕懿群

    [摘要]?目的?觀察川崎病(Kawasaki?disease，KD)患儿血浆转化生长因子-β(transforming?growth?factor-β，TGF-β)和血管内皮生长因子(vascular?endothelial?growth?factor，VEGF)水平，并探讨其与冠状动脉病变(coronary?arterial?lesion，CAL)的相关性。方法?选取2020年10月至2022年6月在嘉兴市第二医院儿科住院的KD患儿105例，根据心脏彩超检查结果分为CAL组(20例)与无CAL组(85例)，同时选取30例健康体检的儿童为对照组。采用酶联免疫吸附试验(enzyme?linked?immunosorbent?assay，ELISA)检测各组血浆TGF-β、VEGF、血管内皮生长因子受体1(vascular?endothelial?growth?factor?receptor-1，VEGFR1)水平，绘制受试者操作特征(receiver?operating?characteristic，ROC)曲线，比较TGF-β、VEGF单独和联合检测在KD并发CAL预测上的差异。结果?KD患儿静脉注射丙种球蛋白(intravenous?immunoglobulin，IVIG)治疗前血浆TGF-β、VEGF和VEGFR1水平明显高于IVIG治疗后(均P0.05)。Spearman直线相关分析结果显示，TGF-β与白细胞、C反应蛋白和红细胞沉降率呈正相关(均P

    [Abstract]?Objective?To?observe?plasma?transforming?growth?factor-β?(TGF-β)?and?vascular?endothelial?growth?factor?(VEGF)?levels?in?Kawasaki?disease?(KD)?children?and?to?explore?the?association?with?coronary?arterial?lesion?(CAL).?Methods?A?total?of?105?children?with?KD?in?Department?of?Pediatrics，?the?Second?Hospital?of?Jiaxing?were?recruited?in?the?present?study?from?October?2020?to?June?2022.?According?to?the?results?of?the?echocardiogram?examination ......