[摘要] 目的 探讨畲药食凉茶组方对痰湿壅盛型肥胖合并阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome，OSAHS)的临床疗效及安全性。方法 选取2023年1月至2024年2月浙江中医药大学附属丽水中医院诊治的痰湿壅盛型肥胖合并OSAHS患者90例，根据随机数字表法将其分为对照组和治疗组，每组45例。对照组患者使用无创呼吸机持续气道正压通气(continuous positive airway pressure，CPAP)，治疗组患者在对照组基础上同时服用畲药食凉茶组方，两组患者均治疗3个月。比较两组患者的体质量指数(body mass index，BMI)、Epworth嗜睡量表(Epworth sleeping scale，ESS)评分、睡眠呼吸暂停指标及不良反应。结果 治疗后，两组患者的ESS评分、BMI、呼吸暂停低通气指数(apnea-hypopnea index，AHI)均显著低于本组治疗前，最低血氧饱和度(minimum blood oxygen saturation，LSaO₂)显著高于本组治疗前(Plt;0.05)；治疗组患者的ESS评分、BMI、AHI均显著低于对照组，LSaO₂显著高于对照组(Plt;0.05)；治疗组患者的不良反应发生率显著低于对照组(c²=6.429，P=0.011)。结论 畲药食凉茶组方治疗痰湿壅盛型肥胖合并OSAHS疗效确切，可降低BMI及ESS评分，改善睡眠呼吸暂停参数，同时减少无创呼吸机辅助通气导致的不良反应。

    [关键词] 畲药食凉茶组方；阻塞性睡眠呼吸暂停低通气综合征；肥胖；痰湿壅盛型；临床疗效；安全性

    [中图分类号] R256.1" """"[文献标识码] A """""[DOI] 10.3969/j.issn.1673-9701.2025.04.016

    [Abstract] ObjectiveTo investigate the clinical efficacy and safety of She medical Shiliangcha compound prescription in treating obesity with syndrome of internal exuberance of phlegm-damp complicated with obstructive sleep apnea hypopnea syndrome (OSAHS). MethodsA total of 90 patients with obesity with syndrome of internal exuberance of phlegm-damp complicated with OSAHS diagnosed and treated in Lishui Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from January 2023 to February 2024 were selected and divided into control group and treatment group according to random number table method ......