新型TOPK抑制剂的设计、合成及抗肿瘤活性研究(8)
[15] V AYLLON， O'CONNOR R. PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response[J]. Oncogene， 2007， 26(24)：3451-3461.
[16] HU F， GARTENHAUS R B， EICHBERG D， et al. PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21[J]. Oncogene， 2010， 29(40)：5464-5474.
[17] ZYKOVA T A， ZHU F， LU C， et al. Lymphokine-Activated Killer T-Cell-Originated Protein Kinase Phosphorylation of Histone H2AX Prevents Arsenite-Induced Apoptosis in RPMI7951 Melanoma Cells[J]. Clinical Cancer Research， 2006， 12(23)：6884-6893.
[18] ZYKOVA T A， ZHU F， VAKORINA T I， et al. T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of Prx1 at Ser-32 Prevents UVB-induced Apoptosis in RPMI7951 Melanoma Cells through the Regulation of Prx1 Peroxidase Activity[J]. Journal of Biological Chemistry， 2010， 285(38)：29138-29146.
[19] KIM D J， LI Y， REDDY K， et al. Novel TOPK Inhibitor HI-TOPK-032 Effectively Suppresses Colon Cancer Growth[J]. Cancer Research， 2012， 72(12)：3060-3068.
[20] 宋樹勇.PBK/TOPK蛋白酶抑制剂喹唑啉衍生物的合成[D].湛江：广东医学院，2016.
[21] MIYAMOTO T. Novel molecule targets cytokinesis[J]. Cancer Discovery， 2015， 5(1)：OF8.
[22] JINXUAN L， JING-YI C， YA-LIN D， et al. Structure-Based Design， Synthesis， Biological Evaluation， and Molecular Docking of Novel PDE10 Inhibitors With Antioxidant Activities[J]. Fronties in Chemustry， 2018， 6：167-178., 百拇医药(黄珍 方宇希 黄志勇 李荣东)
[16] HU F， GARTENHAUS R B， EICHBERG D， et al. PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21[J]. Oncogene， 2010， 29(40)：5464-5474.
[17] ZYKOVA T A， ZHU F， LU C， et al. Lymphokine-Activated Killer T-Cell-Originated Protein Kinase Phosphorylation of Histone H2AX Prevents Arsenite-Induced Apoptosis in RPMI7951 Melanoma Cells[J]. Clinical Cancer Research， 2006， 12(23)：6884-6893.
[18] ZYKOVA T A， ZHU F， VAKORINA T I， et al. T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of Prx1 at Ser-32 Prevents UVB-induced Apoptosis in RPMI7951 Melanoma Cells through the Regulation of Prx1 Peroxidase Activity[J]. Journal of Biological Chemistry， 2010， 285(38)：29138-29146.
[19] KIM D J， LI Y， REDDY K， et al. Novel TOPK Inhibitor HI-TOPK-032 Effectively Suppresses Colon Cancer Growth[J]. Cancer Research， 2012， 72(12)：3060-3068.
[20] 宋樹勇.PBK/TOPK蛋白酶抑制剂喹唑啉衍生物的合成[D].湛江：广东医学院，2016.
[21] MIYAMOTO T. Novel molecule targets cytokinesis[J]. Cancer Discovery， 2015， 5(1)：OF8.
[22] JINXUAN L， JING-YI C， YA-LIN D， et al. Structure-Based Design， Synthesis， Biological Evaluation， and Molecular Docking of Novel PDE10 Inhibitors With Antioxidant Activities[J]. Fronties in Chemustry， 2018， 6：167-178., 百拇医药(黄珍 方宇希 黄志勇 李荣东)