锌剂治疗腹泻患儿前、后的IL—2、IL—6和IL—23动态变化情况研究(1)
[摘要] 目的 探讨锌剂治疗腹泻患儿的IL-2、IL-6和IL-23动态变化情况。 方法 分析腹泻患儿200例和健康儿童50例作为对照组的临床资料，依据治疗措施不同进行临床分组，治疗A组(锌剂治疗轮状病毒组)50例，治疗B组(普通治疗轮状病毒组)50例，治疗C组(锌剂治疗非轮状病毒组)50例，治疗D组(普通治疗非轮状病毒组)50例，健康对照组50例。结果 轮状病毒感染和非轮状病毒感染腹泻患儿的IL-2、IL-6和IL-23均高于对照组，非轮状病毒感染腹泻患儿治疗后IL-2、IL-6和IL-23均优于轮状病毒感染的患儿，同时锌剂治疗后患儿的IL-2、IL-6和IL-23均优于普通治疗后水平，差异有统计学意义(P<0.05)。结论 锌剂治疗腹泻患儿的IL-2、IL-6和IL-23动态变化可以对轮状病毒感染患儿的预防和早期诊治、预防，提供可靠的理论依据。
[关键词] 锌剂；腹泻； IL-2；IL-6；IL-23
[中图分类号] R574.62 [文献标识码] A [文章编号] 1674-0742(2014)01(a)-0018-02
Study on the Dynamic Change of IL-2， IL-6 and IL-23 in Children with Diarrhea Before and after Zinc Treatment
JIANG Xiahui
Maoming Maternity and Child Health Hospital， Maoming， Guangdong Province， 525000， China
[Abstract] Objective To study the dynamic changes of IL-2， IL-6 and IL-23 in children with diarrhea treated by zinc. Methods The clinical data of 200 cases of children with diarrhea and 50 cases of healthy children in the control group were analyzed. According to different treatment measures， they were divided into treatment A group(zinc therapy of rotavirus group)， 50 cases，treatment B group(general treatment of rotavirus group)， 50 cases， treatment C group(zinc therapy of non-rotavirus group )， 50 cases，treatment D group(general treatment of non-rotavirus group)50 cases，and healthy control group， 50 cases. Results The IL-2， IL-6 and IL-23 in children with diarrhea and rotavirus infection or non-rotavirus infection were higher than those of the control group，the IL-2， IL-6 and IL-23 of non-rotavirus infection in children with diarrhea after treatment were better than those in children with diarrhea and rotavirus infection； the levels of IL-2， IL-6 and IL-23 in children with diarrhea treated by zinc were superior to those treated by general treatment(P<0.05)， the differences were statistical significant. Conclusion The dynamic changes of IL-2， IL-6 and IL-23 in children with diarrhea treated by zinc could provide a reliable theoretical basis for the prevention and early diagnosis and treatment of rotavirus infection.
[Key words] Zinc； Diarrhea；IL-2；IL-6；IL-23
轮状病毒(RV)感染全年均有发生，主要流行于秋、冬季，感染对象主要是婴幼儿，RV感染流行地区比较广泛，20世纪70、80年代世界上发生的非细菌性腹泻暴发中30%左右是RV感染所致[1-2]。RV的主要传播方式是粪—口途径，也可以通过污染的水源、食物、物品和空气等传播[3]。IL-6属于Th2细胞因子，具有一定的抗炎作用，其可以通过调控B细胞进而引起肥大细胞脱颗粒，影响胃肠平滑肌的收缩反应。IL-23可以促进抗原递呈细胞分泌和活化，其主要是IL-12家族的一员。IL-23和受体结合之后，对STAT3形成激活，在IL-17A和IL-17F启动区结合，IL-23激活T细胞反应可以被Socs3减弱，从而成为负调节Th17细胞的抑制因子，为探讨锌剂治疗腹泻患儿的IL-2、IL-6和IL-23动态变化情况，该研究分析该院2012年8月—2013年7月间收治的腹泻患儿200例的临床资料，现报道如下。, 百拇医药(江霞辉)
[关键词] 锌剂；腹泻； IL-2；IL-6；IL-23
[中图分类号] R574.62 [文献标识码] A [文章编号] 1674-0742(2014)01(a)-0018-02
Study on the Dynamic Change of IL-2， IL-6 and IL-23 in Children with Diarrhea Before and after Zinc Treatment
JIANG Xiahui
Maoming Maternity and Child Health Hospital， Maoming， Guangdong Province， 525000， China
[Abstract] Objective To study the dynamic changes of IL-2， IL-6 and IL-23 in children with diarrhea treated by zinc. Methods The clinical data of 200 cases of children with diarrhea and 50 cases of healthy children in the control group were analyzed. According to different treatment measures， they were divided into treatment A group(zinc therapy of rotavirus group)， 50 cases，treatment B group(general treatment of rotavirus group)， 50 cases， treatment C group(zinc therapy of non-rotavirus group )， 50 cases，treatment D group(general treatment of non-rotavirus group)50 cases，and healthy control group， 50 cases. Results The IL-2， IL-6 and IL-23 in children with diarrhea and rotavirus infection or non-rotavirus infection were higher than those of the control group，the IL-2， IL-6 and IL-23 of non-rotavirus infection in children with diarrhea after treatment were better than those in children with diarrhea and rotavirus infection； the levels of IL-2， IL-6 and IL-23 in children with diarrhea treated by zinc were superior to those treated by general treatment(P<0.05)， the differences were statistical significant. Conclusion The dynamic changes of IL-2， IL-6 and IL-23 in children with diarrhea treated by zinc could provide a reliable theoretical basis for the prevention and early diagnosis and treatment of rotavirus infection.
[Key words] Zinc； Diarrhea；IL-2；IL-6；IL-23
轮状病毒(RV)感染全年均有发生，主要流行于秋、冬季，感染对象主要是婴幼儿，RV感染流行地区比较广泛，20世纪70、80年代世界上发生的非细菌性腹泻暴发中30%左右是RV感染所致[1-2]。RV的主要传播方式是粪—口途径，也可以通过污染的水源、食物、物品和空气等传播[3]。IL-6属于Th2细胞因子，具有一定的抗炎作用，其可以通过调控B细胞进而引起肥大细胞脱颗粒，影响胃肠平滑肌的收缩反应。IL-23可以促进抗原递呈细胞分泌和活化，其主要是IL-12家族的一员。IL-23和受体结合之后，对STAT3形成激活，在IL-17A和IL-17F启动区结合，IL-23激活T细胞反应可以被Socs3减弱，从而成为负调节Th17细胞的抑制因子，为探讨锌剂治疗腹泻患儿的IL-2、IL-6和IL-23动态变化情况，该研究分析该院2012年8月—2013年7月间收治的腹泻患儿200例的临床资料，现报道如下。, 百拇医药(江霞辉)