低分子肝素在小儿肾病综合征中的疗效探讨(1)
[摘要]目的 探究分析低分子肝素在小儿肾病综合征中的临床疗效及其治疗的安全性。方法 采用回顾性分析的方法，分析了该院儿科在2013年1月—2014年1月间收治的108例肾病综合征的患儿的临床资料。根据治疗药物的不同，将108例患儿随机分成实验组和对照组，每组各54例，对照组采用激素和免疫抑制剂等常规治疗，实验组在对照组常规治疗的基础上加用了低分子肝素，分析对比两组患者的临床治疗有效率和不良反应等情况。结果 对照组的治疗有效率为79.63%，实验组的治疗有效率为94.44%，实验组的治疗有效率明显高于对照组，并且差异有统计学意义(P<0.05)；实验组和对照组的治疗均能改善患儿ATPP、PT、FIB和D-D的状况，但实验组的改善程度较对照组更为显著(P<0.05)；对照组有5例患儿在皮下药物注射部位出现淤血，而实验组患儿无任何不良反应。结论 低分子肝素在治疗小儿肾病综合征上临床疗效好，且能显著改善患儿的凝血功能，安全可靠，值得临床广泛推广使用。
[关键词]肾病综合征；儿童；低分子肝素；疗效分析
[中图分类号]R5 [文献标识码]A [文章编号]1674-0742(2015)04(b)-0084-02
Observation on the Efficacy of Low Molecular Heparin in Pediatric Nephrotic Syndrome Curative
WANG Xiaoju
Department of Heart and Kidney， The First People's Hospital of Urumqi， Urumqi， Xinjiang 830002 China
[Abstract] Objective To explore and analyze the clinical effect and safety of low molecular weight heparin in children with nephrotic syndrome. Methods Retrospective analysis was applied， analyzed the pediatric department of our hospital from January 2013 to January 2014 were treated 108 cases of nephrotic syndrome in children. According to the different drug treatment， 108 patients were randomly divided into experimental group and control group， 54 cases in each group， the control group were given hormones and immune inhibitors and other conventional treatment， the experimental group based on the control group were given routine treatment combined with low molecular heparin， analyzed and compared the effective rate of clinical treatment and adverse reaction etc of the two groups. Results The effective rate of the treatment of control group was 79.63%， the effective rate of the treatment of the experimental group was 94.44%， the effective rate of treatment of experimental group was higher than that of control group， and the difference was statistically significant(P<0.05)； the treatment of the experimental group and the control group were able to improve the children with ATPP， PT， FIB and D-D， but the degree of improvement the experimental group compared with the control group was significant(P<0.05)； the control group had 5 cases occurred in children with congestion in the subcutaneous injection sites， while the experimental group patients without any adverse reaction. Conclusion Low molecular weight heparin in the treatment of children with nephrotic syndrome clinical curative effect is good， and can significantly improve the function of blood coagulation in children， less adverse reaction， safe and reliable， which is worthy of clinical widely used., 百拇医药(王小菊)
[关键词]肾病综合征；儿童；低分子肝素；疗效分析
[中图分类号]R5 [文献标识码]A [文章编号]1674-0742(2015)04(b)-0084-02
Observation on the Efficacy of Low Molecular Heparin in Pediatric Nephrotic Syndrome Curative
WANG Xiaoju
Department of Heart and Kidney， The First People's Hospital of Urumqi， Urumqi， Xinjiang 830002 China
[Abstract] Objective To explore and analyze the clinical effect and safety of low molecular weight heparin in children with nephrotic syndrome. Methods Retrospective analysis was applied， analyzed the pediatric department of our hospital from January 2013 to January 2014 were treated 108 cases of nephrotic syndrome in children. According to the different drug treatment， 108 patients were randomly divided into experimental group and control group， 54 cases in each group， the control group were given hormones and immune inhibitors and other conventional treatment， the experimental group based on the control group were given routine treatment combined with low molecular heparin， analyzed and compared the effective rate of clinical treatment and adverse reaction etc of the two groups. Results The effective rate of the treatment of control group was 79.63%， the effective rate of the treatment of the experimental group was 94.44%， the effective rate of treatment of experimental group was higher than that of control group， and the difference was statistically significant(P<0.05)； the treatment of the experimental group and the control group were able to improve the children with ATPP， PT， FIB and D-D， but the degree of improvement the experimental group compared with the control group was significant(P<0.05)； the control group had 5 cases occurred in children with congestion in the subcutaneous injection sites， while the experimental group patients without any adverse reaction. Conclusion Low molecular weight heparin in the treatment of children with nephrotic syndrome clinical curative effect is good， and can significantly improve the function of blood coagulation in children， less adverse reaction， safe and reliable， which is worthy of clinical widely used., 百拇医药(王小菊)