尼莫地平对高血压脑出血治疗的研究(1)
[摘要] 目的 对尼莫地平用于高血压脑出血治疗的临床效果进行探讨分析。方法 选取2012年8月—2014年8月于该院进行救治的498例高血压脑出血患者，将其随机分为观察组250例与对照组248例，其中对照组采用常规治疗，观察组在对照组的基础上，加用尼莫地平治疗。并且对治疗效果进行观察记录。结果 观察组总有效率为92.4%，对照组总有效率为82.6%，明显低于观察组(χ2=8.4471，P<0.05)；治疗后，观察组三项指标：血肿体积、水肿面积、神经功能评分均比对照组改善明显，各指标内相比差异有统计学意义(P<0.05)；两组患者不良反应率差异无统计学意义(χ2=4.9381，P>0.05)。 结论 尼莫地平治疗高血压脑出血具有疗效好，不良反应低等优点。
[关键词] 尼莫地平；高血压；脑出血；治疗；效果
[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-0742(2015)06(a)-0114-02
Analysis of Clinical Effect of Nimodipine in Treatment of Hypertensive Cerebral Hemorrhage
GUO Zhi-wei， GUAN Shu-fen， ZHAO Xu-wei， ZHANG Yan-li， XIE Xin-jing， ZHANG Ya-nan
Department of Neurosurgery， First Affiliated Hospital of QiQihar Medical University， Qiqihar， Heilongjiang Province， 161041 China
[Abstract] Objective To investigate the application of nimodipine in treating Hypertensive Cerebral Hemorrhage. Methods 498 in-patients with hypertensive cerebral hemorrhage treated in our hospital from August 2012 to August 2014 were selected and randomly divided into observation group and control group. 248 patients in the control received routine treatment， while 250 patients in the observation group was given nimodipine injection based on routine treatment. The therapeutic effectiveness of the two groups was compared. Results The total efficiency of the observation group was 92.4%， which was higher than 82.6% of the control group(P<0.05)； The absorption of hemorrhage， edema and ESS were better in the observation group(P<0.05)； no obvious differences of adverse reaction were observed between the two groups(P>0.05). Conclusion Nimodipine injection in the treatment of patients with HCT has the advantages of remarkable effect and low incidence of adverse reaction. benefit for the absorption of hemorrhage and edema and the improvement of neurological function of patient， which should be widely applied in clinic.
[Key words] Nimodipine； Hypertension； Cerebral Hemorrhage； Treatment； Clinical curative
随着我国居民生活水平的提高和生活方式的不断西化，高血压患者发病率呈逐年上升趋势[1]。高血压是心脑血管疾病的是常见病之一，高血压脑出血是指高血压伴脑小动脉瘤，因血压突然升高引起动脉破裂，具有致残率和致死率高的特点[2]。如何更有效、更安全的治疗，是广大临床医生非常关注的。该院于2012年8月—2014年8月运用尼莫地平对高血压脑出血进行治疗，效果令人满意，现报道如下。
1 资料与方法
1.1 一般资料
整群选取2012年8月—2014年8月于该院进行救治的498例高血压脑出血患者，将其随机分为观察组250例与对照组248例。观察组中，男128例，女122例，年龄25～78岁，平均年龄(47.4±2.9)岁；对照组中，男126例，女122例，平均年龄(48.4±3.1)岁。两组患者在性别、年龄、病程等资料比较，差异无统计学意义(P>0.05)，可比性强。
1.2 纳入标准所有患者发病前均有高血压病史
病发后经头颅CT证实为脑出血；发病后2～4 h内入院；意识清醒或嗜睡、昏睡；出血部位在基底节区和丘脑；无服用钙通道阻断剂史；血肿体积在20～40 mL之间；符合全国第四届脑血管病学术会议修订的诊断标准[3]。排除非原发性高血压、慢性心、肾功能不全者、外伤性脑出血者、脑干或小脑出血、合并其他严重器质性器官衰竭患者[4]。, 百拇医药(郭知伟等)
[关键词] 尼莫地平；高血压；脑出血；治疗；效果
[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-0742(2015)06(a)-0114-02
Analysis of Clinical Effect of Nimodipine in Treatment of Hypertensive Cerebral Hemorrhage
GUO Zhi-wei， GUAN Shu-fen， ZHAO Xu-wei， ZHANG Yan-li， XIE Xin-jing， ZHANG Ya-nan
Department of Neurosurgery， First Affiliated Hospital of QiQihar Medical University， Qiqihar， Heilongjiang Province， 161041 China
[Abstract] Objective To investigate the application of nimodipine in treating Hypertensive Cerebral Hemorrhage. Methods 498 in-patients with hypertensive cerebral hemorrhage treated in our hospital from August 2012 to August 2014 were selected and randomly divided into observation group and control group. 248 patients in the control received routine treatment， while 250 patients in the observation group was given nimodipine injection based on routine treatment. The therapeutic effectiveness of the two groups was compared. Results The total efficiency of the observation group was 92.4%， which was higher than 82.6% of the control group(P<0.05)； The absorption of hemorrhage， edema and ESS were better in the observation group(P<0.05)； no obvious differences of adverse reaction were observed between the two groups(P>0.05). Conclusion Nimodipine injection in the treatment of patients with HCT has the advantages of remarkable effect and low incidence of adverse reaction. benefit for the absorption of hemorrhage and edema and the improvement of neurological function of patient， which should be widely applied in clinic.
[Key words] Nimodipine； Hypertension； Cerebral Hemorrhage； Treatment； Clinical curative
随着我国居民生活水平的提高和生活方式的不断西化，高血压患者发病率呈逐年上升趋势[1]。高血压是心脑血管疾病的是常见病之一，高血压脑出血是指高血压伴脑小动脉瘤，因血压突然升高引起动脉破裂，具有致残率和致死率高的特点[2]。如何更有效、更安全的治疗，是广大临床医生非常关注的。该院于2012年8月—2014年8月运用尼莫地平对高血压脑出血进行治疗，效果令人满意，现报道如下。
1 资料与方法
1.1 一般资料
整群选取2012年8月—2014年8月于该院进行救治的498例高血压脑出血患者，将其随机分为观察组250例与对照组248例。观察组中，男128例，女122例，年龄25～78岁，平均年龄(47.4±2.9)岁；对照组中，男126例，女122例，平均年龄(48.4±3.1)岁。两组患者在性别、年龄、病程等资料比较，差异无统计学意义(P>0.05)，可比性强。
1.2 纳入标准所有患者发病前均有高血压病史
病发后经头颅CT证实为脑出血；发病后2～4 h内入院；意识清醒或嗜睡、昏睡；出血部位在基底节区和丘脑；无服用钙通道阻断剂史；血肿体积在20～40 mL之间；符合全国第四届脑血管病学术会议修订的诊断标准[3]。排除非原发性高血压、慢性心、肾功能不全者、外伤性脑出血者、脑干或小脑出血、合并其他严重器质性器官衰竭患者[4]。, 百拇医药(郭知伟等)