[摘要] 目的 探讨利培酮合并氯氮平治疗难治性精神分裂症临床应用效果。方法 对照组给予利培酮常规治疗；研究组实施利培酮联合氯氮平片疗法。将两组中难治性精神分裂症患者的疗效及不良反应发生状况记录，通过统计学分析得出结论。结果 研究组临床治疗的总有效率为88.37%，明显优于对照组临床治疗总有效率69.77%(P<0.05)；研究组发生不良反应率为27.91%，比对照组(20.93%)略高，但对比两组结果差异无统计学意义(P>0.05)。 结论 难治性精神分裂症患者经利培酮联合氯氮平治疗可显著提高其临床疗效，有效保障患者生活质量及生命安全。

    [关键词] 难治性精神分裂症；利培酮；氯氮平；临床疗效

    [中图分类号] R749 [文献标识码] A [文章编号] 1674-0742(2015)06(c)-0125-02

    [Abstract] Objective To investigate the clinical effect of risperidone combined with clozapine in the treatment of refractory schizophrenia. Methods The control group received conventional treatment with risperidone； study group received combined treatment of risperidone and clozapine. Outcomes and adverse reaction of the patients with refractory schizophrenia in the two groups were recorded and statistically analyzed. Results Clinical total efficiency of the study group ......