[摘要] 目的 探讨ⅢB期结肠癌组织中高迁移率族蛋白1的表达及其临床意义。 方法 整群选取该院收治的72例ⅢB期结肠癌患者资料进行分析，采用免疫组织化学染色及免疫双染色技术对高迁移率族蛋白1表达及淋巴细胞浸润情况进行分析，研究高迁移率族蛋白1在ⅢB期结肠癌患者中的表达及临床意义。结果 在结肠癌组织HMGB1弱表达标本(-、+)中CD3+、CD45RO+淋巴细胞的浸润密度明显低于HMGB1强表达标本((++，+++)(P<0.05)；HMGB1和性别、年龄、原发肿瘤、病理分级等差异不显著(P>0.05)。结论 高迁移率族蛋白1核质共表达时淋巴细胞清润较少，且患者生存率降低，能够反应ⅢB期结肠癌患者预后，值得推广使用。

    [关键词] ⅢB期结肠癌组织；高迁移率族蛋白1；表达；临床意义

    [中图分类号] R59 [文献标识码] A [文章编号] 1674-0742(2015)08(b)-0030-02

    [Abstract] Objective To discuss the expression of high mobility group box-1 protein (HMGB1) in stage ⅢB colon cancer tissue and its clinical significance. Methods The clinical data of 72 patients with stage ⅢB colon cancer was selected as the research object. The expression of HMGB1 in their colon cancer tissue and their lymphocytic infiltrates were analyzed by immunohistochemical staining method and double immunostaining technique to study its clinical significance. Results Infiltrated density of CD3+ ......