病理诊断HER—2过表达乳腺癌与三阴性乳腺癌的特征比较(1)
[摘要] 目的 比较病理诊断HER-2过表达乳腺癌与三阴性乳腺癌的特征。方法 整群选取该院2013年1月—2015年5月收治182例浸润性乳腺癌患者进行研究，根据免疫组化法检测结果分为A组(HER-2过表达乳腺癌组)与B组(三阴性乳腺癌组)，对比两组淋巴结转移、组织学分级、AJCC分期情况。 结果 B组淋巴结转移率达到69.6%，明显高于A组47.4%，差异有统计学意义(P<0.05)；且B组淋巴结转移数量≥10枚所占百分率，也明显高于A组，差异有统计学意义(P<0.05)。A组中3级患者所占百分率为36.8%，明显低于B组中65.2%，差异有统计学意义(P<0.05)。结论 三阴性乳腺癌及HER-2过表达乳腺癌均以浸润性导管癌为主，前者三阴侵袭性更强，恶性程度更高，易发生淋巴结转移，与HER-2过表达乳腺癌相比预后更难以保证，需引起重视。
[关键词] HER-2过表达；三阴性乳腺癌；恶性程度；转移
[中图分类号] R7 [文献标识码] A [文章编号] 1674-0742(2015)08(c)-0018-02
Comparison of Pathological Characteristics Between HER-2 Over-expression Breast Cancer and TNBC
ZHOU Shu-min
Department of Pathology， Zhoukou Central Hospital， Zhoukou， Henan Province， 466000 China
[Abstract] Objective To compare the pathological characteristics between HER-2 over-expression breast cancer and triple-negative breast cancer (TNBC). Methods 182 patients with invasive breast cancer admitted to the hospital between January 2013 and May 2015 were studied and divided into group A (HER-2 over-expression breast cancer group) and group B (TNBC group) according to the detection results of immunohistochemical assay. The lymph node metastasis， histological grade and the status of AJCC staging of the two groups were compared. Results The rate of lymph node metastasis in group B reached 69.6% which was significantly higher than 47.4% in group A， and the difference was statistically significant (P<0.05)； and the percentage of the number of lymph node metastasis equal to or more than 10 in group B was also significantly higher than that in group A and the difference was statistically significant (P<0.05). In group A， the percentage of patients of level three was 36.8% which was significantly lower than 65.2% in group B and the difference was statistically significant (P<0.05). Conclusion The TNBC and HER-2 over-expression breast cancer mainly are infiltrating ductal carcinoma. The triple negative invasion of the former is stronger with higher degree of malignancy and is prone to appear lymph node metastasis. Compared with HER-2 over-expression breast cancer， its prognosis is more difficult to guarantee， so attention should be paid to it.
[Key words] HER-2 over-expression； Triple-negative breast cancer； Degree of malignancy； Metastasis
乳腺癌为女性常见恶性肿瘤，在部分地区其已经位居女性恶性肿瘤首位[1]。激素受体阴性乳腺癌普遍存在复发率高、组织学分化差、生存期短等特点，传统内分泌治疗难以取得理想效果。由于激素受体阴性乳腺癌亚型较多，且不同亚型生物学特性有较大差异。临床根据人表皮生长因子受体2(Her-2)表达情况将乳腺癌分为HER-2过表达乳腺癌与三阴性乳腺癌两种[2]，前者指Her-2阳性、孕激素受体(PR)与雌激素受体(ER)均为阴性，后者则指Her-2、PR、ER均呈阴性。该文以该院2013年1月—2015年5月收治浸润性乳腺癌患者为例，对HER-2过表达乳腺癌与三阴性乳腺癌的特征进行比较，现报道如下。, http://www.100md.com(周淑敏)
[关键词] HER-2过表达；三阴性乳腺癌；恶性程度；转移
[中图分类号] R7 [文献标识码] A [文章编号] 1674-0742(2015)08(c)-0018-02
Comparison of Pathological Characteristics Between HER-2 Over-expression Breast Cancer and TNBC
ZHOU Shu-min
Department of Pathology， Zhoukou Central Hospital， Zhoukou， Henan Province， 466000 China
[Abstract] Objective To compare the pathological characteristics between HER-2 over-expression breast cancer and triple-negative breast cancer (TNBC). Methods 182 patients with invasive breast cancer admitted to the hospital between January 2013 and May 2015 were studied and divided into group A (HER-2 over-expression breast cancer group) and group B (TNBC group) according to the detection results of immunohistochemical assay. The lymph node metastasis， histological grade and the status of AJCC staging of the two groups were compared. Results The rate of lymph node metastasis in group B reached 69.6% which was significantly higher than 47.4% in group A， and the difference was statistically significant (P<0.05)； and the percentage of the number of lymph node metastasis equal to or more than 10 in group B was also significantly higher than that in group A and the difference was statistically significant (P<0.05). In group A， the percentage of patients of level three was 36.8% which was significantly lower than 65.2% in group B and the difference was statistically significant (P<0.05). Conclusion The TNBC and HER-2 over-expression breast cancer mainly are infiltrating ductal carcinoma. The triple negative invasion of the former is stronger with higher degree of malignancy and is prone to appear lymph node metastasis. Compared with HER-2 over-expression breast cancer， its prognosis is more difficult to guarantee， so attention should be paid to it.
[Key words] HER-2 over-expression； Triple-negative breast cancer； Degree of malignancy； Metastasis
乳腺癌为女性常见恶性肿瘤，在部分地区其已经位居女性恶性肿瘤首位[1]。激素受体阴性乳腺癌普遍存在复发率高、组织学分化差、生存期短等特点，传统内分泌治疗难以取得理想效果。由于激素受体阴性乳腺癌亚型较多，且不同亚型生物学特性有较大差异。临床根据人表皮生长因子受体2(Her-2)表达情况将乳腺癌分为HER-2过表达乳腺癌与三阴性乳腺癌两种[2]，前者指Her-2阳性、孕激素受体(PR)与雌激素受体(ER)均为阴性，后者则指Her-2、PR、ER均呈阴性。该文以该院2013年1月—2015年5月收治浸润性乳腺癌患者为例，对HER-2过表达乳腺癌与三阴性乳腺癌的特征进行比较，现报道如下。, http://www.100md.com(周淑敏)