VEGF、c—erbB—2与NSCLC血管生成及淋巴道转移相关性的研究(1)
[摘要] 目的 探讨VEGF、c-erbB-2与NSCLC血管生成及淋巴道转移的相关性。方法 方便选取聊城市中医院2004—2012年非小细胞肺癌存档蜡块54例作为观察组，对照组选择20例肺良性病变手术切除标本，观察两组的VEGF、c-erbB-2水平。结果 54例非小细胞肺癌组织病理切片中，C-erbB-2阳性表达40例，阴性表达14例，阳性表达率达74.07%，两者比较有显著差异(P<0.05)。54例非小细胞肺癌肺癌组织病理切片中，VEGF阳性表达36例，阴性18例，阳性表达率为66.67%，肺良性病变中，VEGF阳性2例，阴性18例，阳性表达率为10%，两者比较有显著生物学差异。结论 VEGF、c-erbB-2与非小细胞肺癌的发生发展中密切相关，并在此过程中起到一定的调控作用， VEGF、c-erbB-2表达增强预示着患者较易发生淋巴结转移，提示患者预后不佳，有助于早期判断预后。
[关键词] VEGF；c-erbB-2；NSCLC；血管生成；淋巴道转移
[中图分类号] R737.9 [文献标识码] A [文章编号] 1674-0742(2016)05(a)-0053-03
[Abstract] Objective To discuss the correlation between VEGF， c-erbB-2 and NSCLC angiogenesis and lymphatic metastasis. Methods 54 cases of stored paraffin blocks of non-small cell lung cancer from 2004 to 2012 were regarded as the observation group， 20 cases of surgical excision specimens of benign pulmonary lesions were selected as the control group， and the VEGF and c-erbB-2 levels of the two groups were observed. Results In the 54 cases of pathologic tissue slices of non-small cell lung cancer， the positive expression of C-erbB-2 was in 40 cases and the negative expression of C-erbB-2 was in 14 cases， and the positive expression rate was 74.07%， and there was an obvious difference between the two by comparison(P<0.05)， the positive expression of VEGF was in 36 cases and negative expression of VEGF was in 18 cases， and the positive expression rate was 66.67%， in the benign pulmonary lesions， positive VEGF was in 2 cases， negative VEGF was in 18 cases， and the positive expression rate was 10%， and there was an obvious biological difference between the two by comparison. Conclusion VEGF and c-erbB-2 are closely related to the occurrence and development of non-small cell lung cancer and play a certain regulation role in this process， and the expression intensity of VEGF and c-erbB-2 indicates that lymphatic metastasis easily occurs to patients and reminds poor prognoses of patients， which is conducive to the early judgment of prognosis.
[Key words] VEGF； c-erbB-2； NSCLC； Angiogenesis； Lymphatic metastasis
肺癌是临床常见肿瘤，非小细胞肺癌占所有肺癌的绝大部分[1]。肺癌发病机制复杂，吸烟是非小细胞肺癌最主要的致病因素。85%以上的肺癌发生都可归因于主动吸烟或被动吸烟[2]。在北美、北欧、澳大利亚及新西兰，吸烟是女性肺癌的主要致病因素，其他地区的女性肺癌与厨房油烟吸入关系更为密切。吸烟者肺癌的发生与吸烟的年数、每日吸烟的数量、初始吸烟的年龄、香烟的类型、肺癌家族史等均有关[3]。吸烟指数(每天吸烟支数×吸烟年数)>400者为高危人群。为探讨VEGF、c-erbB-2与NSCLC血管生成及淋巴道转移的相关性，该研究选取聊城市中医院2010—2015年非小细胞肺癌存档蜡块54例作为观察组，对照组选择20例肺良性病变手术切除标本，取得的满意的结果，现报道如下。
1 资料与方法
1.1 一般资料
所有标本来自聊城市中医院行胸外科手术切除肺叶的非小细胞肺癌存档蜡块54例，所有患者均知情同意，并通过伦理委员会的批准。观察组：其中男性36例，女性18例，年龄≥60岁的31例，<60岁的23例；高中分化36例，低分化18例；≤3 cm的20例，>3 cm的34例；鳞癌24例，腺癌30例，有淋巴结转移的31例，无淋巴结转移的23例。所有病例术前均未经治疗。所有病例切片均经HE染色，由2名有经验的医生光镜下复诊，有争议者第三者复核后确定。对照组：选择20例肺良性病变手术切除标本，其中肺大泡15例，肺结核3例，炎性假瘤2例。 (盛仲楠 袁博 司保达)
[关键词] VEGF；c-erbB-2；NSCLC；血管生成；淋巴道转移
[中图分类号] R737.9 [文献标识码] A [文章编号] 1674-0742(2016)05(a)-0053-03
[Abstract] Objective To discuss the correlation between VEGF， c-erbB-2 and NSCLC angiogenesis and lymphatic metastasis. Methods 54 cases of stored paraffin blocks of non-small cell lung cancer from 2004 to 2012 were regarded as the observation group， 20 cases of surgical excision specimens of benign pulmonary lesions were selected as the control group， and the VEGF and c-erbB-2 levels of the two groups were observed. Results In the 54 cases of pathologic tissue slices of non-small cell lung cancer， the positive expression of C-erbB-2 was in 40 cases and the negative expression of C-erbB-2 was in 14 cases， and the positive expression rate was 74.07%， and there was an obvious difference between the two by comparison(P<0.05)， the positive expression of VEGF was in 36 cases and negative expression of VEGF was in 18 cases， and the positive expression rate was 66.67%， in the benign pulmonary lesions， positive VEGF was in 2 cases， negative VEGF was in 18 cases， and the positive expression rate was 10%， and there was an obvious biological difference between the two by comparison. Conclusion VEGF and c-erbB-2 are closely related to the occurrence and development of non-small cell lung cancer and play a certain regulation role in this process， and the expression intensity of VEGF and c-erbB-2 indicates that lymphatic metastasis easily occurs to patients and reminds poor prognoses of patients， which is conducive to the early judgment of prognosis.
[Key words] VEGF； c-erbB-2； NSCLC； Angiogenesis； Lymphatic metastasis
肺癌是临床常见肿瘤，非小细胞肺癌占所有肺癌的绝大部分[1]。肺癌发病机制复杂，吸烟是非小细胞肺癌最主要的致病因素。85%以上的肺癌发生都可归因于主动吸烟或被动吸烟[2]。在北美、北欧、澳大利亚及新西兰，吸烟是女性肺癌的主要致病因素，其他地区的女性肺癌与厨房油烟吸入关系更为密切。吸烟者肺癌的发生与吸烟的年数、每日吸烟的数量、初始吸烟的年龄、香烟的类型、肺癌家族史等均有关[3]。吸烟指数(每天吸烟支数×吸烟年数)>400者为高危人群。为探讨VEGF、c-erbB-2与NSCLC血管生成及淋巴道转移的相关性，该研究选取聊城市中医院2010—2015年非小细胞肺癌存档蜡块54例作为观察组，对照组选择20例肺良性病变手术切除标本，取得的满意的结果，现报道如下。
1 资料与方法
1.1 一般资料
所有标本来自聊城市中医院行胸外科手术切除肺叶的非小细胞肺癌存档蜡块54例，所有患者均知情同意，并通过伦理委员会的批准。观察组：其中男性36例，女性18例，年龄≥60岁的31例，<60岁的23例；高中分化36例，低分化18例；≤3 cm的20例，>3 cm的34例；鳞癌24例，腺癌30例，有淋巴结转移的31例，无淋巴结转移的23例。所有病例术前均未经治疗。所有病例切片均经HE染色，由2名有经验的医生光镜下复诊，有争议者第三者复核后确定。对照组：选择20例肺良性病变手术切除标本，其中肺大泡15例，肺结核3例，炎性假瘤2例。 (盛仲楠 袁博 司保达)