万州区宫颈癌危险因素病例对照研究(1)
[摘要] 目的 探讨万州区妇女宫颈癌发病危险因素，为该地区宫颈癌有针对性的早期防治提供科学依据。 方法 随机选取以2011年1月—2015年12月5年间年龄在30～65岁的96例万州区妇幼保健院确诊宫颈癌患者为病例组，随机抽取同期全区两癌筛查中同龄非宫颈癌妇女200名为对照组，对其个人习惯、月经史、婚育史、性行为史、妇科病史、肿瘤家族史以及HPV感染等进行调查分析，筛选该区妇女宫颈癌发病危险因素。 结果 经Logistic回归分析表明，多次人流、早孕、HPV感染、妇科病史、初潮年龄过早和吸烟都与宫颈癌的发生密切相关(P<0.05)，OR值分别为5.9、4.91、2.94、2.68、2.34、1.56。 结论 该区宫颈癌发病结构呈现年轻化趋势，要提高重视度。为宫颈上皮内瘤变(CIN)患者建立上级保健医院同社区卫生服务中心的个人档案双向反馈机制，提高对宫颈癌的早筛查、早发现、早治疗，从而有效防止宫颈癌的发生和提高患者5年生存率。
[关键词] 宫颈癌 ；危险因素； 病例对照研究； Logistic回归分析
[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-0742(2016)10(b)-0001-03
[Abstract] Objective To explore the risk factors of cervical cancer in Wanzhou District， and to provide scientific evidence for the early prevention and treatment of cervical cancer in the region. Methods Random selection from January 2011 to December 2015 five-year age 30～65 96 Wanzhou District Maternal and child health hospital diagnosed cervical cancer patients as a case group， randomly selected from the same region Two Cancer Screening age non cervical cancer in women， 200 as control， were used to investigate and analyze the personal habits， menstrual history， obstetrical history， sexual history， gynecological disease， tumor family history and HPV infection， screening the risk factors of cervical cancer in this area. Results Logistic regression analysis showed that， repeated abortion， early pregnancy， HPV infection， gynecological history， early age at menarche and smoking are and cervical cancer occurrence is closely related (P < 0.05). The OR Value were 5.9 and 4.91， 2.94， 2.68， 2.34， 1.56. Conclusion The incidence of cervical cancer in this area is younger and younger， which should be improved. for cervical intraepithelial neoplasia (CIN) in patients with established superior care hospital with community health service center profile of two-way feedback mechanism to improve on cervical cancer early screening， early discovery， early treatment， so as to effectively prevent cervical cancer occurrence and improve the patient's 5 year survival rate.
[Key words] Cervical cancer； Risk factors ；Case-control study； Logistic regression analysis
宫颈癌是全球常见妇科恶性肿瘤之一，发病率仅次于乳腺癌。在我国，宫颈癌的年死亡率约为4.3/10万，已经成为影响我国女性健康的第二大恶性肿瘤[1]。万州区地处三峡库区，是重庆市第二大城市。从2009年开展两癌筛查工作以来，该区宫颈癌的早期诊断率明显上升，晚期宫颈癌的发生率明显降低，两癌工作卓有成效。但是，随着地区社会经济的发展，人民群众的生活方式、心理状态以及家庭结构方面都在不断变化，宫颈癌病因更加复杂多样，宫颈癌的发生也呈现出一些新的态势，有针对性的开展本地区宫颈癌发病危险因素的调查势在必行。万州区妇幼保健院负责全区妇女两癌筛查的组织、实施和督导工作，在宫颈癌病因调查上有其特有的优势，该次调查以2011年1月—2015年12月5年间年龄在30～65岁的96例万州区妇幼保健院年宫颈癌病理确诊患者为病例组，随机抽取同期全区两癌筛查同年龄段非宫颈癌妇女200名为对照组开展病例对照研究，现报道如下。 (黄若愚 易东)
[关键词] 宫颈癌 ；危险因素； 病例对照研究； Logistic回归分析
[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-0742(2016)10(b)-0001-03
[Abstract] Objective To explore the risk factors of cervical cancer in Wanzhou District， and to provide scientific evidence for the early prevention and treatment of cervical cancer in the region. Methods Random selection from January 2011 to December 2015 five-year age 30～65 96 Wanzhou District Maternal and child health hospital diagnosed cervical cancer patients as a case group， randomly selected from the same region Two Cancer Screening age non cervical cancer in women， 200 as control， were used to investigate and analyze the personal habits， menstrual history， obstetrical history， sexual history， gynecological disease， tumor family history and HPV infection， screening the risk factors of cervical cancer in this area. Results Logistic regression analysis showed that， repeated abortion， early pregnancy， HPV infection， gynecological history， early age at menarche and smoking are and cervical cancer occurrence is closely related (P < 0.05). The OR Value were 5.9 and 4.91， 2.94， 2.68， 2.34， 1.56. Conclusion The incidence of cervical cancer in this area is younger and younger， which should be improved. for cervical intraepithelial neoplasia (CIN) in patients with established superior care hospital with community health service center profile of two-way feedback mechanism to improve on cervical cancer early screening， early discovery， early treatment， so as to effectively prevent cervical cancer occurrence and improve the patient's 5 year survival rate.
[Key words] Cervical cancer； Risk factors ；Case-control study； Logistic regression analysis
宫颈癌是全球常见妇科恶性肿瘤之一，发病率仅次于乳腺癌。在我国，宫颈癌的年死亡率约为4.3/10万，已经成为影响我国女性健康的第二大恶性肿瘤[1]。万州区地处三峡库区，是重庆市第二大城市。从2009年开展两癌筛查工作以来，该区宫颈癌的早期诊断率明显上升，晚期宫颈癌的发生率明显降低，两癌工作卓有成效。但是，随着地区社会经济的发展，人民群众的生活方式、心理状态以及家庭结构方面都在不断变化，宫颈癌病因更加复杂多样，宫颈癌的发生也呈现出一些新的态势，有针对性的开展本地区宫颈癌发病危险因素的调查势在必行。万州区妇幼保健院负责全区妇女两癌筛查的组织、实施和督导工作，在宫颈癌病因调查上有其特有的优势，该次调查以2011年1月—2015年12月5年间年龄在30～65岁的96例万州区妇幼保健院年宫颈癌病理确诊患者为病例组，随机抽取同期全区两癌筛查同年龄段非宫颈癌妇女200名为对照组开展病例对照研究，现报道如下。 (黄若愚 易东)