脑梗死二级预防中阿司匹林抵抗及其与血管事件的关系(1)
[摘要] 目的 分析在脑梗死二级预防中出现AR的概率，同时对随访期间，复发脑梗死、AR以及血管事件的关系进行探究。方法 整群择取2014年3月—2016年4月该院收治的422例脑梗死患者作为此次研究对象，所选患者均于入院当日起服用阿司匹林，7～10 d后对患者血小板集聚率进行检测，将敏感者、AR者筛选出来，对选出患者进行随访，为期0.5～2.0年，对其他血管事件的出现以及复发脑梗死情况进行观察，分析AR与血管事件出现的原因以及预后情况。结果 所选患者中，105例出现AR(24.88%)，317例出现敏感情况(75.12%)；出现AR的患者中，糖尿病患者与女性患者比例、LDL胆固醇均明显高于出现敏感情况患者，糖尿病、LDL胆固醇升高属于出现AR危险因素；随访期间，出现AR的患者复发脑梗死、发生心肌梗死概率、全因死亡概率明显高于出现敏感情况的患者；糖尿病、动脉粥样硬化脑梗死属于随访期间出现血管事件的危险因素。结论 在脑梗死二级预防中，出现AR的概率比较高，AR是随访期间复发脑梗死、出现血管事件的危险因素。
[关键词] 脑梗死二级预防；阿司匹林抵抗；血管事件；关系
[中图分类号] R543 [文献标识码] A [文章编号] 1674-0742(2017)02(a)-0120-03
[Abstract] Objective To analyze the occurrence probability of AR in the secondary prevention of cerebral infarction and study the correlation between recurrence of cerebral infarction， AR and vascular events during the follow-up period. Methods Group selection 422 cases of patients with cerebral infarction admitted and treated in our hospital from March 2014 to April 2016 were selected as the research objects and took take aspirin on the day of admission， and the platelet aggregation rate of patients was tested after 7 to 10 days， and the sensitive persons and AR patients were screened out， and the selected patients were followed for 0.5 to 2.0 years， and the occurrence of other vascular events and recurrence of cerebral infarction were observed， and the occurrence causes of AP and vascular events and prognosis were analyzed. Results AP was in 105 cases， accounting for 24.88%， and sensitive condition occurred to 317 cases， accounting for 75.12%， and the ratio of diabetes patients and female patients and LDL cholesterin were obviously higher than the sensitive patients， and the diabetes and LDL cholesterin increase were the AP risk factors， during the follow-up period， and the diabetes and atherosclerotic cerebral infarction were the risk factors of occurrence of vascular events. Conclusion In the secondary prevention of cerebral infarction， the occurrence probability of AR is higher， and the AR is the risk factor of recurrence of cerebral infarction and occurrence of vascular events during the follow-up period.
[Key words] Secondary prevention of cerebral infarction； Aspirin resistance； Vascular event； Correlation
伴隨人们生活水平提升，生活方式转变，脑血管病的病死率逐年递增，其中以脑梗死为主，且具有较高的致残率和复发率，使居民健康受到严重威胁[1]。脑梗死二级预防是针对已经出现脑梗死疾病患者给予的预防治疗对策，主要目的是为了降低致残率和病死率，改善临床症状，避免疾病复发[2]。阿司匹林是脑梗死二级预防中的主要药物，患者通过口服阿司匹林药物，对其危险因素进行控制，但一些患者用药后仍会发生其他血管事件、疾病复发。据相关研究表明，出现血管事件的患者中，AR患者高于敏感患者[3]。基于此，整群择取2014年3月—2016年4月该院收治的脑梗死患者422例作为研究对象，分析在脑梗死二级预防中出现AR的概率，同时对随访期间，复发脑梗死、AR以及出现血管事件的关系进行探究，现报道如下。, 百拇医药(马涛)
[关键词] 脑梗死二级预防；阿司匹林抵抗；血管事件；关系
[中图分类号] R543 [文献标识码] A [文章编号] 1674-0742(2017)02(a)-0120-03
[Abstract] Objective To analyze the occurrence probability of AR in the secondary prevention of cerebral infarction and study the correlation between recurrence of cerebral infarction， AR and vascular events during the follow-up period. Methods Group selection 422 cases of patients with cerebral infarction admitted and treated in our hospital from March 2014 to April 2016 were selected as the research objects and took take aspirin on the day of admission， and the platelet aggregation rate of patients was tested after 7 to 10 days， and the sensitive persons and AR patients were screened out， and the selected patients were followed for 0.5 to 2.0 years， and the occurrence of other vascular events and recurrence of cerebral infarction were observed， and the occurrence causes of AP and vascular events and prognosis were analyzed. Results AP was in 105 cases， accounting for 24.88%， and sensitive condition occurred to 317 cases， accounting for 75.12%， and the ratio of diabetes patients and female patients and LDL cholesterin were obviously higher than the sensitive patients， and the diabetes and LDL cholesterin increase were the AP risk factors， during the follow-up period， and the diabetes and atherosclerotic cerebral infarction were the risk factors of occurrence of vascular events. Conclusion In the secondary prevention of cerebral infarction， the occurrence probability of AR is higher， and the AR is the risk factor of recurrence of cerebral infarction and occurrence of vascular events during the follow-up period.
[Key words] Secondary prevention of cerebral infarction； Aspirin resistance； Vascular event； Correlation
伴隨人们生活水平提升，生活方式转变，脑血管病的病死率逐年递增，其中以脑梗死为主，且具有较高的致残率和复发率，使居民健康受到严重威胁[1]。脑梗死二级预防是针对已经出现脑梗死疾病患者给予的预防治疗对策，主要目的是为了降低致残率和病死率，改善临床症状，避免疾病复发[2]。阿司匹林是脑梗死二级预防中的主要药物，患者通过口服阿司匹林药物，对其危险因素进行控制，但一些患者用药后仍会发生其他血管事件、疾病复发。据相关研究表明，出现血管事件的患者中，AR患者高于敏感患者[3]。基于此，整群择取2014年3月—2016年4月该院收治的脑梗死患者422例作为研究对象，分析在脑梗死二级预防中出现AR的概率，同时对随访期间，复发脑梗死、AR以及出现血管事件的关系进行探究，现报道如下。, 百拇医药(马涛)