丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作的疗效(1)
[摘要] 目的 研究探讨应用丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作的临床疗效。方法 方便选取该院2014年9月—2016年10月收治的86例双相情感障碍躁狂发作患者，随机分成对照组(丙戊酸钠联合氯丙嗪)与联合组(丙戊酸钠联合喹硫平)，每组43例。记录两组患者治疗前后认知功能、临床效果及不良反应发生情况。 结果 治疗2个月后联合组治愈率为65.12%显著高于对照组的55.81%(P<0.05)；联合组持续应答数及错误应答数改善情况显著优于对照组(P<0.05)；联合组不良反应发生率为11.63%，对照组则为25.58%，组间差异有统计学意义(P<0.05)。 结论 应用丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作能显著改善患者个别认知功能，提高其注意力、记忆力、执行功能等，临床成效显著且不良反应发生率低，值得推广。
[关键词] 双相情感障碍躁狂发作；喹硫平；丙戊酸钠
[中图分类号] R749 [文献标识码] A [文章编号] 1674-0742(2017)04(a)-0139-03
Curative Effect of Sodium Valproate and Quetiapine in Treatment of Manic Episode of Bipolar Disorder
LIANG Yong， YU Xin-ming
First Department of Psychiatry， Chuzhou Second People’s Hospital， Chuzhou， Anhui Province， 239001 China
[Abstract] Objective To research the clinical curative effect of sodium valproate and quetiapine in treatment of manic episode of bipolar disorder. Methods Convenient selection 86 cases of patients with manic episode of bipolar disorder admitted and treated in our hospital from September 2014 to October 2016 were selected and randomly divided into two groups with 43 cases in each， the control group were treated with sodium valproate and chlorpromazine， while the combined group were treated with sodium valproate and quetiapine， and the cognitive function， clinical effect and occurrence of adverse reactions before and after treatment of the two groups were recorded. Results The cure rate in the combined group after 2-month treatment was obviously higher than that in the control group(65.12% vs 55.81%)(P<0.05)， and the improvement situation of continuous answer number and wrong answer number in the combined group were obviously better than those in the control group(P<0.05)， and the difference in the incidence rate of adverse reactions between the combined group and the control group was obvious(11.63% vs 25.58%)(P<0.05). Conclusion The application of sodium valproate and quetiapine in treatment of manic episode of bipolar disorder can obviously improve the individual cognitive function of patients and improve the attention， memory and executive function with obvious clinical effect and low incidence rate of adverse reactions， and it is worth promotion.
[Key words] Manic episode of bipolar disorder； Quetiapine； Sodium valproate
双相情感障碍发作机制及临床表现复杂，采用单药疗效较差，现临床常联合使用心境稳定剂与抗精神病药物进行治疗[1]。丙戊酸盐是该病常用药物，但协助治疗的氯丙嗪可诱发患者抑郁及安全性问题，为此需寻找安全性高，疗效显著的药物替代氯丙嗪。《双相障碍防治指南》中指出非典型抗精神病药物可以用于辅助治療且不良反应小[2]。该实验方便选取该院2014年9月—2016年10月收治的86例双相情感障碍躁狂发作患者进行分析以探讨丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作的临床疗效，现报道如下。, 百拇医药(梁勇 余鑫铭)
[关键词] 双相情感障碍躁狂发作；喹硫平；丙戊酸钠
[中图分类号] R749 [文献标识码] A [文章编号] 1674-0742(2017)04(a)-0139-03
Curative Effect of Sodium Valproate and Quetiapine in Treatment of Manic Episode of Bipolar Disorder
LIANG Yong， YU Xin-ming
First Department of Psychiatry， Chuzhou Second People’s Hospital， Chuzhou， Anhui Province， 239001 China
[Abstract] Objective To research the clinical curative effect of sodium valproate and quetiapine in treatment of manic episode of bipolar disorder. Methods Convenient selection 86 cases of patients with manic episode of bipolar disorder admitted and treated in our hospital from September 2014 to October 2016 were selected and randomly divided into two groups with 43 cases in each， the control group were treated with sodium valproate and chlorpromazine， while the combined group were treated with sodium valproate and quetiapine， and the cognitive function， clinical effect and occurrence of adverse reactions before and after treatment of the two groups were recorded. Results The cure rate in the combined group after 2-month treatment was obviously higher than that in the control group(65.12% vs 55.81%)(P<0.05)， and the improvement situation of continuous answer number and wrong answer number in the combined group were obviously better than those in the control group(P<0.05)， and the difference in the incidence rate of adverse reactions between the combined group and the control group was obvious(11.63% vs 25.58%)(P<0.05). Conclusion The application of sodium valproate and quetiapine in treatment of manic episode of bipolar disorder can obviously improve the individual cognitive function of patients and improve the attention， memory and executive function with obvious clinical effect and low incidence rate of adverse reactions， and it is worth promotion.
[Key words] Manic episode of bipolar disorder； Quetiapine； Sodium valproate
双相情感障碍发作机制及临床表现复杂，采用单药疗效较差，现临床常联合使用心境稳定剂与抗精神病药物进行治疗[1]。丙戊酸盐是该病常用药物，但协助治疗的氯丙嗪可诱发患者抑郁及安全性问题，为此需寻找安全性高，疗效显著的药物替代氯丙嗪。《双相障碍防治指南》中指出非典型抗精神病药物可以用于辅助治療且不良反应小[2]。该实验方便选取该院2014年9月—2016年10月收治的86例双相情感障碍躁狂发作患者进行分析以探讨丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作的临床疗效，现报道如下。, 百拇医药(梁勇 余鑫铭)