美罗培南与亚胺培南—西司他丁钠治疗老年重度医院获得性肺炎的临床疗效(1)
DOI：10.16662/j.cnki.1674-0742.2017.11.147
[摘要] 目的 对美罗培南与亚胺培南-西司他丁钠治疗老年重度医院获得性肺炎的临床疗效进行分析。方法 在2014年8月—2016年9月期间，该院总共收治老年重度医院获得性肺炎患者90例，将其作为该次研究对象，根据不同治疗方法，将其具体分为实验组46例患者，对照组44例患者，其中实验组采取美罗培南治疗，对照组采取亚胺培南-西司他丁钠治疗，观察两组患者临床疗效和细菌清除情况，不良反应以及细菌敏感情况。结果 实验组患者总有效率为89.1%，对照组总有效率为75.0%，实验组患者细菌清除率97.6%，对照组患者细菌清除率81%，实验组明显高于对照组，差异有统计学意义(P<0.05)；而实验组的不良反应发病率6.5%，细菌敏感率69.7%，对照组的不良反应发病率22.7%，细菌敏感率89.1%，所以，实验组患者低于对照组，对比差异无统计学意义(P<0.05)。结论 研究发现，老年重度医院获得性肺炎患者进行治疗时，美罗培南与亚胺培南-西司他丁钠治疗均能改善患者病情，其中美罗培南临床效果更加理想，值得对治疗方法进行推广。
[关键词] 美罗培南；亞胺培南-西司他丁钠；老年重度医院获得性肺炎
[中图分类号] R563.1 [文献标识码] A [文章编号] 1674-0742(2017)04(b)-0147-03
Clinical Curative Effect of Meropenem and Imipenem(N Formimidoyl Thienamycin) Treatment of Senile Patients with Severe Hospital-acquired Pneumonia
ZHANG Xiang-le
Department of Respiration Medicine， Xishuangbanna People's Hospital， Jinghong， Yunnan Province， 666100 China
[Abstract] Objective To analyze the clinical curative effect of meropenem and imipenem (N formimidoyl thienamycin) treatment of senile patients with severe hospital-acquired pneumonia. Methods 90 cases of senile patients with severe Hospital-acquired pneumonia admitted and treated in our hospital from August 2014 to September 2016 were selected and divided into two groups in each according to different treatment methods， the experimental group with 46 cases were treated with meropenem， while the control group were treated with imipenem(N formimidoyl thienamycin)， and the clinical curative effect and bacterial clearance situation， adverse reactions and bacterial sensitivity situation of the two groups were observed. Results The total effective rate and bacterial clearance rate in the experimental group were obviously higher than those in the control group，(89.1%， 97.6% vs 75.0%， 81%)， and the differences between groups were statistically significant(P<0.05)， but the morbidity of adverse reactions and bacterial sensitive rate in the experimental group were lower than those in the control group (6.5%， 69.7% vs 22.7%， 89.1%)， and the differences between groups were not statistically significant(P<0.05). Conclusion The research showed that the meropenem and imipenem (N formimidoyl thienamycin) treatment of senile patients with severe hospital-acquired pneumonia can improve the disease conditions of patients， but the clinical effect of meropenem is more ideal， which is worth promotion.
[Key words] Meropenem； Imipenem (N formimidoyl thienamycin)； Senile patients with severe Hospital-acquired pneumonia, 百拇医药(张祥乐)
[摘要] 目的 对美罗培南与亚胺培南-西司他丁钠治疗老年重度医院获得性肺炎的临床疗效进行分析。方法 在2014年8月—2016年9月期间，该院总共收治老年重度医院获得性肺炎患者90例，将其作为该次研究对象，根据不同治疗方法，将其具体分为实验组46例患者，对照组44例患者，其中实验组采取美罗培南治疗，对照组采取亚胺培南-西司他丁钠治疗，观察两组患者临床疗效和细菌清除情况，不良反应以及细菌敏感情况。结果 实验组患者总有效率为89.1%，对照组总有效率为75.0%，实验组患者细菌清除率97.6%，对照组患者细菌清除率81%，实验组明显高于对照组，差异有统计学意义(P<0.05)；而实验组的不良反应发病率6.5%，细菌敏感率69.7%，对照组的不良反应发病率22.7%，细菌敏感率89.1%，所以，实验组患者低于对照组，对比差异无统计学意义(P<0.05)。结论 研究发现，老年重度医院获得性肺炎患者进行治疗时，美罗培南与亚胺培南-西司他丁钠治疗均能改善患者病情，其中美罗培南临床效果更加理想，值得对治疗方法进行推广。
[关键词] 美罗培南；亞胺培南-西司他丁钠；老年重度医院获得性肺炎
[中图分类号] R563.1 [文献标识码] A [文章编号] 1674-0742(2017)04(b)-0147-03
Clinical Curative Effect of Meropenem and Imipenem(N Formimidoyl Thienamycin) Treatment of Senile Patients with Severe Hospital-acquired Pneumonia
ZHANG Xiang-le
Department of Respiration Medicine， Xishuangbanna People's Hospital， Jinghong， Yunnan Province， 666100 China
[Abstract] Objective To analyze the clinical curative effect of meropenem and imipenem (N formimidoyl thienamycin) treatment of senile patients with severe hospital-acquired pneumonia. Methods 90 cases of senile patients with severe Hospital-acquired pneumonia admitted and treated in our hospital from August 2014 to September 2016 were selected and divided into two groups in each according to different treatment methods， the experimental group with 46 cases were treated with meropenem， while the control group were treated with imipenem(N formimidoyl thienamycin)， and the clinical curative effect and bacterial clearance situation， adverse reactions and bacterial sensitivity situation of the two groups were observed. Results The total effective rate and bacterial clearance rate in the experimental group were obviously higher than those in the control group，(89.1%， 97.6% vs 75.0%， 81%)， and the differences between groups were statistically significant(P<0.05)， but the morbidity of adverse reactions and bacterial sensitive rate in the experimental group were lower than those in the control group (6.5%， 69.7% vs 22.7%， 89.1%)， and the differences between groups were not statistically significant(P<0.05). Conclusion The research showed that the meropenem and imipenem (N formimidoyl thienamycin) treatment of senile patients with severe hospital-acquired pneumonia can improve the disease conditions of patients， but the clinical effect of meropenem is more ideal， which is worth promotion.
[Key words] Meropenem； Imipenem (N formimidoyl thienamycin)； Senile patients with severe Hospital-acquired pneumonia, 百拇医药(张祥乐)