21例甲状旁腺功能减退症的临床分析(1)
[摘要] 目的 分析甲状旁腺功能减退症的临床资料，了解其临床表现，为临床诊断、治疗提供参考。方法 研究阶段为2012年9月—2016年12月，病例方便收集来自天津医科大学总医院和天津市第四医院，共纳入研究对象21例，均为甲状旁腺功能减退症患者，继发性甲状旁腺功能减退症患者为A组共6例，特发性甲状旁腺功能减退症(IHP)为B组，分析两组甲状旁腺患者的基本临床资料、首发症状，进行实验室检查和头CT表现。结果 两组一般资料包括年龄、性别、病程差异无统计学意义(χ2/t=0.19、0.25、0.41，P>0.05)，两组临床表现包括手足搐搦、口周麻木或刺痛、头晕、癫痫、双上肢震颤差异无统计学意义(χ2=0.51、0.33、0.32、0.29、0.18，P>0.05)。A组血钙(2.03±0.03)mmol/L、血磷(1.66±0.51)mmol/L、PTH(14.62±2.46)pg/mL與B组血钙(1.43±0.29)mmol/L、血磷(2.18±0.42)mmol/L、PTH(9.03±4.98)pg/mL比较，差异有统计学意义(t=5.36、4.82、5.02，P<0.05)。A组双侧基底节区钙化3例(50.0%)与B组双侧基底节区钙化11例(73.33%)差异有统计学意义(χ2=4.96，P<0.05)。结论 针对甲状旁腺功能减退症患者需要完善相关检查，不能单纯以某一项检查结果作为诊断依据确诊，而是应该结合实验室检查、CT检查等实现全面性的了解，实现确诊。
[关键词] 甲状旁腺功能减退症；临床表现；特征；诊断
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2018)02(c)-0034-03
Clinical Analysis of 21 Cases of Hypoparathyroidism
LIANG Jie ，YANG Jun-feng， HE Qing
Department of Endocrinology， Tianjin Medical University General Hospital， Tianjin， 300070 China
[Abstract] Objective This paper tries to analyze the clinical data of hypoparathyroidism， and to understand its clinical manifestations， so as to provide reference for clinical diagnosis and treatmen. Methods The study period was from September 2012 to December 2016. Cases were conveniently collected from the General Hospital of Tianjin Medical University and the Fourth Hospital of Tianjin. A total of 21 cases were included in the study， both of which were hypoparathyroidism patients. Patients with secondary hypoparathyroidism included 6 cases in group A and IHP in group B. The basic clinical data and initial symptoms of the two groups of parathyroid patients were analyzed. Room examination and head CT performance. Results The two groups of general information including age， gender， duration of disease was not significantly different (χ2/t=0.19，0.25，0.41，P>0.05)， Clinical manifestations of the two groups including tetany， perioral numbness or tingling， dizziness， epilepsy. Tremor no significant difference(χ2=0.51，0.33，0.32，0.29，0.18， P>0.05). A group of blood calcium(2.03±0.03)mmol/L， blood phosphorus(1.66±0.51)mmol/L， PTH(14.62±2.46)pg/mL was compared with group B blood calcium(1.43±0.29)mmol/L， blood phosphorus(2.18±0.42)mmol/L， PTH(9.03±4.98)pg/mL， and the difference was statistically significant(t=5.36，4.82，5.02，P<0.05). A group of bilateral basal ganglia calcification in 3 cases (50.0%) and B group bilateral basal ganglia calcification in 11 cases (73.33%) significant difference(χ2=4.96，P<0.05). Conclusion The hypoparathyroidism patients need to improve the relevant examination， not only to a certain examination results as a diagnostic basis for diagnosis， but should be combined with the laboratory examination， CT examination to achieve comprehensive understanding， implementation of the diagnosis., 百拇医药(梁洁 杨俊峰 何庆)
[关键词] 甲状旁腺功能减退症；临床表现；特征；诊断
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2018)02(c)-0034-03
Clinical Analysis of 21 Cases of Hypoparathyroidism
LIANG Jie ，YANG Jun-feng， HE Qing
Department of Endocrinology， Tianjin Medical University General Hospital， Tianjin， 300070 China
[Abstract] Objective This paper tries to analyze the clinical data of hypoparathyroidism， and to understand its clinical manifestations， so as to provide reference for clinical diagnosis and treatmen. Methods The study period was from September 2012 to December 2016. Cases were conveniently collected from the General Hospital of Tianjin Medical University and the Fourth Hospital of Tianjin. A total of 21 cases were included in the study， both of which were hypoparathyroidism patients. Patients with secondary hypoparathyroidism included 6 cases in group A and IHP in group B. The basic clinical data and initial symptoms of the two groups of parathyroid patients were analyzed. Room examination and head CT performance. Results The two groups of general information including age， gender， duration of disease was not significantly different (χ2/t=0.19，0.25，0.41，P>0.05)， Clinical manifestations of the two groups including tetany， perioral numbness or tingling， dizziness， epilepsy. Tremor no significant difference(χ2=0.51，0.33，0.32，0.29，0.18， P>0.05). A group of blood calcium(2.03±0.03)mmol/L， blood phosphorus(1.66±0.51)mmol/L， PTH(14.62±2.46)pg/mL was compared with group B blood calcium(1.43±0.29)mmol/L， blood phosphorus(2.18±0.42)mmol/L， PTH(9.03±4.98)pg/mL， and the difference was statistically significant(t=5.36，4.82，5.02，P<0.05). A group of bilateral basal ganglia calcification in 3 cases (50.0%) and B group bilateral basal ganglia calcification in 11 cases (73.33%) significant difference(χ2=4.96，P<0.05). Conclusion The hypoparathyroidism patients need to improve the relevant examination， not only to a certain examination results as a diagnostic basis for diagnosis， but should be combined with the laboratory examination， CT examination to achieve comprehensive understanding， implementation of the diagnosis., 百拇医药(梁洁 杨俊峰 何庆)