丁苯酞软胶囊治疗腔隙性脑梗死运动性失语的临床探讨(1)
[摘要] 目的 探讨丁苯酞软胶囊治疗腔隙性脑梗死运动性失语的临床效果。方法 随机选取2016年6月—2017年11月该院收治的100例腔隙性脑梗死运动性失语患者为研究对象，按照住院先后顺序将其分为观察组与对照组。每组50例，在常规对症治疗的基础上，给予对照组患者尼莫地平进行治疗，同时给予观察组患者丁苯酞软胶囊进行治疗。观察两组患者治疗前后语言功能及CADL和AQ评分。结果 经治疗后，观察组患者治疗后语言功能评分分别为口语理解(128.52±31.13)分、自发言语(14.68±4.43)分、命名(77.63±18.24)分、复述(83.53±14.12)分明显高于对照组，差异有统计学意义(t=28.421、10.126、18.624、24.268，P<0.05)；且观察组患者治疗后CADL评分(108.32±21.59)分和AQ评分(73.34±16.31)分明显高于对照组，且比较差异有统计学意义(t=31.024、23.012，P<0.05)。结论 丁苯酞软胶囊治疗腔隙性脑梗死运动性失语有着较好的临床效果，能改善患者语言功能，提升其日常生活交流能力，值得进行深入研究和推广。
[关键词] 丁苯酞软胶囊；腔隙性脑梗死；运动性失语
[中图分类号] R743 [文献标识码] A [文章编号] 1674-0742(2018)05(a)-0104-03
Clinical Discussion on Butylphthalide Soft Capsules in Treatment of Aphemia of Lacunar Infarction
CHEN Fen-wei， LIU Dong-wei， HUANG Ji-feng
Department of Cranial Brain， Pengpai Memorial Hospital， Haifeng， Guangdong Province， 516400 China
[Abstract] Objective To study the clinical effect of butylphthalide soft capsules in treatment of aphemia of lacunar infarction. Methods 100 cases of patients with aphemia of lacunar infarction admitted and treated in our hospital from June 2016 to November 2017 were random selected and randomly divided into two groups with 50 cases in each， both groups used the routine systematic therapy， the control group were treated with nimodipine， while the observation group were treated with butylphthalide soft capsules， and the linguistic function， CADL and AQ scores before and after treatment of the two groups were observed. Results After treatment， the speech understanding， spontaneous speech， name， and repetition in the observation group were respectively (128.52±31.13)points， (14.68±4.43)points， (77.63±18.24)points and (83.53±14.12)points， and the differences were statistically significant (t=28.421， 10.126， 18.624， 24.268， P<0.05) ， and the CADL score and AQ score after treatment in the observation group were respectively (108.32±21.59)points and(73.34±16.31)points， which were higher than those in the control group， and the differences were statistically significant(t=31.024， 23.012， P<0.05). Conclusion The clinical effect of butylphthalide soft capsules in treatment of aphemia of lacunar infarction is better， which can improve the linguistic function and improve the communication skill of daily activities， and it is worth deep research and promotion.
[Key words] Butylphthalide soft capsules； Lacunar cerebral infarction； Aphemia
脑梗死是常见神经内科疾病，病死率、致残率等都比较高，对人们身心健康造成严重威胁[1]。腔隙性梗死是常见的脑血管病之一，是持续性高血压、小动脉硬化引起的一种特殊類型的脑血管病。失语症是腔隙性脑梗死引起的最常见同时也是最严重的并发症之一[2]，近三成的脑梗死患者伴发失语，而其中又以运动性失语(Broca失语)为主。语言障碍以口语表达障碍为主，听理解功能相对较好，严重影响到日常生活质量。丁苯酞是国内自行研制的新型神经保护药物，可作用于脑梗死病理，也可保护患者神经[3]。该研究随机选取2016年6月—2017年11月该院收治的100例患者为研究对象，论证丁苯酞软胶囊治疗腔隙性脑梗塞失语症的临床疗效，现报道如下。, 百拇医药(陈奋伟 刘东炜 黄季凤)
[关键词] 丁苯酞软胶囊；腔隙性脑梗死；运动性失语
[中图分类号] R743 [文献标识码] A [文章编号] 1674-0742(2018)05(a)-0104-03
Clinical Discussion on Butylphthalide Soft Capsules in Treatment of Aphemia of Lacunar Infarction
CHEN Fen-wei， LIU Dong-wei， HUANG Ji-feng
Department of Cranial Brain， Pengpai Memorial Hospital， Haifeng， Guangdong Province， 516400 China
[Abstract] Objective To study the clinical effect of butylphthalide soft capsules in treatment of aphemia of lacunar infarction. Methods 100 cases of patients with aphemia of lacunar infarction admitted and treated in our hospital from June 2016 to November 2017 were random selected and randomly divided into two groups with 50 cases in each， both groups used the routine systematic therapy， the control group were treated with nimodipine， while the observation group were treated with butylphthalide soft capsules， and the linguistic function， CADL and AQ scores before and after treatment of the two groups were observed. Results After treatment， the speech understanding， spontaneous speech， name， and repetition in the observation group were respectively (128.52±31.13)points， (14.68±4.43)points， (77.63±18.24)points and (83.53±14.12)points， and the differences were statistically significant (t=28.421， 10.126， 18.624， 24.268， P<0.05) ， and the CADL score and AQ score after treatment in the observation group were respectively (108.32±21.59)points and(73.34±16.31)points， which were higher than those in the control group， and the differences were statistically significant(t=31.024， 23.012， P<0.05). Conclusion The clinical effect of butylphthalide soft capsules in treatment of aphemia of lacunar infarction is better， which can improve the linguistic function and improve the communication skill of daily activities， and it is worth deep research and promotion.
[Key words] Butylphthalide soft capsules； Lacunar cerebral infarction； Aphemia
脑梗死是常见神经内科疾病，病死率、致残率等都比较高，对人们身心健康造成严重威胁[1]。腔隙性梗死是常见的脑血管病之一，是持续性高血压、小动脉硬化引起的一种特殊類型的脑血管病。失语症是腔隙性脑梗死引起的最常见同时也是最严重的并发症之一[2]，近三成的脑梗死患者伴发失语，而其中又以运动性失语(Broca失语)为主。语言障碍以口语表达障碍为主，听理解功能相对较好，严重影响到日常生活质量。丁苯酞是国内自行研制的新型神经保护药物，可作用于脑梗死病理，也可保护患者神经[3]。该研究随机选取2016年6月—2017年11月该院收治的100例患者为研究对象，论证丁苯酞软胶囊治疗腔隙性脑梗塞失语症的临床疗效，现报道如下。, 百拇医药(陈奋伟 刘东炜 黄季凤)