甲基强的松龙联合丙种球蛋白治疗腹型过敏性紫癜的可行性研究(1)
[摘要] 目的 分析研究甲基强的松龙联合丙种球蛋白治疗腹型过敏性紫癜的可行性。方法 随机抽取2015年1月—2017年8月收治的60例腹型过敏性紫癜患儿，根据随机数字表法将其分为对照组(n=30)与实验组(n=30)，对照组患儿予以甲基强的松龙治疗，实验组患儿予以甲基强的松龙联合丙种球蛋白进行治疗，观察两组患儿治疗过程中的病情变化与治疗期间、随访期间的疾病复发情况。结果 实验组患儿在治疗过程中的皮疹开始消退时间(5.24±0.71)d、皮疹完全消退(16.72±4.36)d、腹痛缓解时间(4.28±0.64)d、血便消失時间(4.21±0.53)d与住院时间(13.24±1.83)d明显短于对照组，差异有统计学意义(t=9.594、6.284、19.255、14.285、12.554，P<0.05)。随访期间，实验组0例(0.00%)患儿出现疾病复发现象，明显少于对照组8例(26.67%)，差异有统计学意义(χ2=9.231，P=0.002)。结论 对腹型过敏性紫癜患儿予以甲基强的松龙联合丙种球蛋白治疗能够有效的缓解患儿的病情，对患儿具有安全性，说明该种方法具有可行性。
[关键词] 甲基强的松龙；丙种球蛋白；腹型过敏性紫癜；可行性
[中图分类号] R554 [文献标识码] A [文章编号] 1674-0742(2018)05(c)-0120-03
[Abstract] Objective This paper tries to analyze the feasibility of anaphylactic purpura methylprednisolone combined with gamma globulin in treatment of abdominal type methylprednisolone. Methods 60 children with abdominal allergic purpura from January 2015 to August 2017 were randomly selected and divided into a control group (n=30) and an experimental group (n=30). Methylprednisolone was used to treat patients in the control group. Methylprednisolone and gamma globulin were administered to the patients in the experimental group to observe the changes in the course of treatment and the recurrence of disease during and after the treatment. Results In the experimental group， the rash began to fade in the treatment period (5.24±0.71)d， the rash completely subsided (16.72±4.36)d， the abdominal pain relief time (4.28±0.64)d， and the blood stool disappear time (4.21±0.53)d. The hospitalization time (13.24±1.83)d was significantly shorter than that of the control group， with a significant difference (t=9.594， 6.284， 19.255， 14.285， 12.554， P<0.05). During the follow-up period， 0 cases (0.00%) children in the experimental group had recurrent disease， which was significantly less than that in the control group 8 cases(26.67%). The difference was statistically significant(χ2=9.231，P=0.002). Conclusion Methylprednisolone combined with gamma globulin in children with abdominal anaphylactoid purpura can effectively relieve the condition of children， and it is safe for children， indicating that this method is feasible.
[Key words] Methylprednisolone； Gamma globulin； Abdominal hypersensitivity purpura； Feasibility
过敏性紫癜是小儿常见的出血病症之一，也是最常见的毛细血管变态反应性疾病，该疾病多发于2～8岁的儿童群体，其主要的致病因素与细菌、病毒感染有关，常见的致病菌为链球菌，若未予以及时的治疗，则将引发水疱、血疱，甚至溃疡等严重后果[1]。依临床研究可知[2]，约有67%的儿童将出现腹痛、便血症状，此即为腹型过敏性紫癜，若未采取有效的治疗，将危及儿童的生命安全。使用甲基强的松龙联合丙种球蛋白的方式可有效缓解患儿病情。现随机选取2015年1月—2017年8月该院收治的60例患儿为研究对象，将甲基强的松龙联合丙种球蛋白治疗腹型过敏性紫癜的可行性进行如下分析研究，现报道如下。, 百拇医药(蒋运生 刘武辉 陈秋阳)
[关键词] 甲基强的松龙；丙种球蛋白；腹型过敏性紫癜；可行性
[中图分类号] R554 [文献标识码] A [文章编号] 1674-0742(2018)05(c)-0120-03
[Abstract] Objective This paper tries to analyze the feasibility of anaphylactic purpura methylprednisolone combined with gamma globulin in treatment of abdominal type methylprednisolone. Methods 60 children with abdominal allergic purpura from January 2015 to August 2017 were randomly selected and divided into a control group (n=30) and an experimental group (n=30). Methylprednisolone was used to treat patients in the control group. Methylprednisolone and gamma globulin were administered to the patients in the experimental group to observe the changes in the course of treatment and the recurrence of disease during and after the treatment. Results In the experimental group， the rash began to fade in the treatment period (5.24±0.71)d， the rash completely subsided (16.72±4.36)d， the abdominal pain relief time (4.28±0.64)d， and the blood stool disappear time (4.21±0.53)d. The hospitalization time (13.24±1.83)d was significantly shorter than that of the control group， with a significant difference (t=9.594， 6.284， 19.255， 14.285， 12.554， P<0.05). During the follow-up period， 0 cases (0.00%) children in the experimental group had recurrent disease， which was significantly less than that in the control group 8 cases(26.67%). The difference was statistically significant(χ2=9.231，P=0.002). Conclusion Methylprednisolone combined with gamma globulin in children with abdominal anaphylactoid purpura can effectively relieve the condition of children， and it is safe for children， indicating that this method is feasible.
[Key words] Methylprednisolone； Gamma globulin； Abdominal hypersensitivity purpura； Feasibility
过敏性紫癜是小儿常见的出血病症之一，也是最常见的毛细血管变态反应性疾病，该疾病多发于2～8岁的儿童群体，其主要的致病因素与细菌、病毒感染有关，常见的致病菌为链球菌，若未予以及时的治疗，则将引发水疱、血疱，甚至溃疡等严重后果[1]。依临床研究可知[2]，约有67%的儿童将出现腹痛、便血症状，此即为腹型过敏性紫癜，若未采取有效的治疗，将危及儿童的生命安全。使用甲基强的松龙联合丙种球蛋白的方式可有效缓解患儿病情。现随机选取2015年1月—2017年8月该院收治的60例患儿为研究对象，将甲基强的松龙联合丙种球蛋白治疗腹型过敏性紫癜的可行性进行如下分析研究，现报道如下。, 百拇医药(蒋运生 刘武辉 陈秋阳)