玻璃酸钠联合复方丹参注射液对骨性膝关节炎患者炎性因子及膝关节功能的影响(1)
[摘要] 目的 研究骨性膝關节炎患者采用玻璃酸钠联合复方丹参注射液治疗的临床效果，探讨其对患者炎性因子和膝关节功能的影响。 方法 方便选取105例该院2014年4月—2016年4月期间收治的骨性膝关节炎患者作为研究对象，按随机排列表法分为3组，各35例。其中35例患者单纯采用玻璃酸钠治疗作为玻璃酸钠组，另35例患者单纯采用复方丹参注射液治疗作为复方丹参组，最后35例患者采用玻璃酸钠联合复方丹参注射液治疗作为联合组。观察3组患者治疗效果、血清炎性因子水平、膝关节功能、疼痛情况以及不良反应等。结果 3组患者治疗效果差异有统计学意义，联合组94.29%明显高于玻璃酸钠组的71.43%以及复方丹参组的74.29%(χ2=6.756，P<0.05)。3组患者治疗前IL-6、IL-1β以及TNF-α水平差异无统计学意义(F=0.00，0.02，0.01，P>0.05)；治疗后联合组IL-6、IL-1β以及TNF-α水平明显高于玻璃酸钠组和复方丹参组(F=482.08，42.59，369.30，P<0.05)。3组患者治疗前HSS以及VAS评分均差异无统计学意义(F=0.00，0.04，P>0.05)；治疗后联合组HSS以及VAS评分均优于玻璃酸钠组和复方丹参组(F=25.07，88.41，P<0.05)。3组患者不良反应包括皮疹、食欲下降以及恶心呕吐，3组患者发生率均差异无统计学意义(χ2=0.129，P>0.05)。结论 玻璃酸钠联合复方丹参注射液对骨性膝关节炎患者具有较好治疗效果，改善关节功能，减少疼痛，降低血清炎性因子水平，不良反应低，值得临床应用及推广。
[关键词] 玻璃酸钠；复方丹参注射液；骨性膝关节炎；炎性因子；关节功能
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2018)06(c)-0001-05
[Abstract] Objective This paper tries to investigate the clinical effects of sodium hyaluronate combined with Danshen injection in patients with osteoarthritis of the knee， and to explore the influence of the patients on inflammatory factors and knee joint function. Methods 105 patients with clinically skeletal knee arthritis who were admitted to our hospital from April 2014 to April 2016 were included in the study and were convenient selected and divided into three groups of 35 patients according to the random row table method. Among them， 35 patients only used sodium hyaluronate as the sodium hyaluronate group， while the other 35 patients simply used compound Danshen injection as the compound Danshen group， and the last 35 patients used sodium hyaluronate combined with compound Danshen injection as the combined group. Observed three groups of patients treatment effect， serum inflammatory factors， knee function， pain and adverse reactions. Results The treatment effects of the three groups were statistically significant， with 94.29% in the combination group being significantly higher than 71.43% in the sodium hyaluronate group and 74.29% in the compound Danshen group (χ2=6.756， P<0.05). There was no significant difference in the levels of IL-6， IL-1β and TNF-α before treatment in the three groups (F=0.00， 0.02， 0.01， P>0.05). The levels of IL-6， IL-1β and TNF-α in the combined group after treatment were significantly different. It was higher than sodium hyaluronate group and compound salvia miltiorrhiza group (F=482.08， 42.59， 369.30， P<0.05). There were no significant differences in HSS and VAS scores before treatment between the three groups (F=0.00， 0.04， P>0.05). HSS and VAS scores in the combined group after the treatment were better than those in the sodium hyaluronate group and the compound Danshen group (F=25.07， 88.41， P<0.05). The adverse reactions of the three groups included rash， loss of appetite， and nausea and vomiting. There was no significant difference in the incidence of the three groups (χ2=0.129， P>0.05). Conclusion Sodium hyaluronate combined with compound Danshen injection has a good therapeutic effect on patients with osteoarthritis of the knee， improves joint function， reduces pain， lowers the level of serum inflammatory factors， and has low adverse reactions. It is worthy of clinical application and promotion., 百拇医药(田磊)
[关键词] 玻璃酸钠；复方丹参注射液；骨性膝关节炎；炎性因子；关节功能
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2018)06(c)-0001-05
[Abstract] Objective This paper tries to investigate the clinical effects of sodium hyaluronate combined with Danshen injection in patients with osteoarthritis of the knee， and to explore the influence of the patients on inflammatory factors and knee joint function. Methods 105 patients with clinically skeletal knee arthritis who were admitted to our hospital from April 2014 to April 2016 were included in the study and were convenient selected and divided into three groups of 35 patients according to the random row table method. Among them， 35 patients only used sodium hyaluronate as the sodium hyaluronate group， while the other 35 patients simply used compound Danshen injection as the compound Danshen group， and the last 35 patients used sodium hyaluronate combined with compound Danshen injection as the combined group. Observed three groups of patients treatment effect， serum inflammatory factors， knee function， pain and adverse reactions. Results The treatment effects of the three groups were statistically significant， with 94.29% in the combination group being significantly higher than 71.43% in the sodium hyaluronate group and 74.29% in the compound Danshen group (χ2=6.756， P<0.05). There was no significant difference in the levels of IL-6， IL-1β and TNF-α before treatment in the three groups (F=0.00， 0.02， 0.01， P>0.05). The levels of IL-6， IL-1β and TNF-α in the combined group after treatment were significantly different. It was higher than sodium hyaluronate group and compound salvia miltiorrhiza group (F=482.08， 42.59， 369.30， P<0.05). There were no significant differences in HSS and VAS scores before treatment between the three groups (F=0.00， 0.04， P>0.05). HSS and VAS scores in the combined group after the treatment were better than those in the sodium hyaluronate group and the compound Danshen group (F=25.07， 88.41， P<0.05). The adverse reactions of the three groups included rash， loss of appetite， and nausea and vomiting. There was no significant difference in the incidence of the three groups (χ2=0.129， P>0.05). Conclusion Sodium hyaluronate combined with compound Danshen injection has a good therapeutic effect on patients with osteoarthritis of the knee， improves joint function， reduces pain， lowers the level of serum inflammatory factors， and has low adverse reactions. It is worthy of clinical application and promotion., 百拇医药(田磊)