硫酸氢氯吡格雷与阿司匹林治疗冠心病的临床效果和不良反应对比评价(1)
[摘要] 目的 對比评价硫酸氢氯吡格雷与阿司匹林治疗冠心病的临床效果和不良反应。方法 方便选取该院自2016年1月—2018年1月接收的冠心病患者60例作为研究对象，随机分成两组：一组为氯吡格雷组(30例)，均采用硫酸氢氯吡格雷治疗；一组为阿司匹林组(30例)，均采用阿司匹林治疗；观察比较两组在治疗前后的凝血指标水平、临床疗效及不良反应。结果 治疗前两组的凝血酶原时间[(11.5±1.7)s、(11.6±1.5)s]和活化部分凝血活酶时间(33.3±1.5)s、(33.5±1.6)s]比较差异无统计学意义(t=0.305、1.012，P>0.05)；治疗后氯吡格雷组的凝血酶原时间(12.7±1.6)s显著高于阿司匹林组(11.8±1.8)s，差异有统计学意义(t=2.297，P<0.05)，氯吡格雷组的活化部分凝血活酶时间(41.8±1.6)s显著高于阿司匹林组(37.6±1.7)s，差异有统计学意义(t=12.539，P<0.05)。氯吡格雷组的治疗总有效率93.3%显著高于阿司匹林组73.3%，差异有统计学意义(χ2=7.217，P<0.05)。氯吡格雷组的不良反应发生率6.7%显著低于阿司匹林组23.3%，差异有统计学意义(χ2=6.153，P<0.05)。结论 采用硫酸氢氯吡格雷治疗冠心病比采用阿司匹林治疗的临床效果更加显著，不良反应也更少，值得临床首选。
[关键词] 硫酸氢氯吡格雷；阿司匹林；冠心病；疗效；不良反应
[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-0742(2018)11(b)-0112-03
Evaluation on Comparison of Clinical Effect and Adverse Reactions of Clopidogrel Hydrogen Sulfate Combined with Aspirin in Treatment of Coronary Heart Disease
YANG Xiu-qing
First Affiliated Hospital of Baotou Medical College Inner Mongolia University of Science and Technology， Baotou， Inner Mongolia， 014010 China
[Abstract] Objective To compare the clinical effect and adverse reactions of clopidogrel hydrogen sulfate combined with aspirin in treatment of coronary heart disease. Methods 60 cases of patients with coronary heart disease admitted and treated in our hospital from January 2016 to January 2018 were convenient selected and randomly divided into two groups with 30 cases in each， the clopidogrel hydrogen sulfate group were treated with clopidogrel hydrogen sulfate， while the aspirin group were treated with aspirin， and the coagulation index level， clinical curative effect and adverse reactions were compared between the two groups before and after treatment. Results Before treatment， the differences in the prothrombin time and activated partial thromboplastin time between the two groups were not obvious(11.5±1.7)s， (11.6±1.5)s，(33.3±1.5)s， (33.5±1.6)s，(t=0.305， 1.012， P>0.05) ， after treatment， the prothrombin time in the clopidogrel hydrogen sulfate group was obviously higher than that in the aspirin group[(12.7±1.6) s vs (11.8±1.8)s]，the difference was statistically significant(t=2.297， P<0.05)， and the activated partial thromboplastin time in the clopidogrel hydrogen sulfate group was obviously higher than that in the aspire group[(41.8±1.6) s vs (37.6±1.7)s]，the difference was statistically significant(t=12.539， P<0.05)， and the total treatment effective rate in the clopidogrel hydrogen sulfate group was obviously higher than that in the aspirin group(93.3% vs 73.3%)，the difference was statistically significant(χ2=7.217， P<0.05)， and the incidence rate of adverse reactions in the clopidogrel hydrogen sulfate group was obviously lower than that in the aspirin group(6.7% vs 23.3%)，the difference was statistically significant(χ2=6.153， P<0.05). Conclusion The clinical effect of clopidogrel hydrogen sulfate in treatment of coronary heart disease is more obvious than that of aspirin， with fewer adverse reactions， and it is worth clinical reference., http://www.100md.com(杨秀清)
[关键词] 硫酸氢氯吡格雷；阿司匹林；冠心病；疗效；不良反应
[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-0742(2018)11(b)-0112-03
Evaluation on Comparison of Clinical Effect and Adverse Reactions of Clopidogrel Hydrogen Sulfate Combined with Aspirin in Treatment of Coronary Heart Disease
YANG Xiu-qing
First Affiliated Hospital of Baotou Medical College Inner Mongolia University of Science and Technology， Baotou， Inner Mongolia， 014010 China
[Abstract] Objective To compare the clinical effect and adverse reactions of clopidogrel hydrogen sulfate combined with aspirin in treatment of coronary heart disease. Methods 60 cases of patients with coronary heart disease admitted and treated in our hospital from January 2016 to January 2018 were convenient selected and randomly divided into two groups with 30 cases in each， the clopidogrel hydrogen sulfate group were treated with clopidogrel hydrogen sulfate， while the aspirin group were treated with aspirin， and the coagulation index level， clinical curative effect and adverse reactions were compared between the two groups before and after treatment. Results Before treatment， the differences in the prothrombin time and activated partial thromboplastin time between the two groups were not obvious(11.5±1.7)s， (11.6±1.5)s，(33.3±1.5)s， (33.5±1.6)s，(t=0.305， 1.012， P>0.05) ， after treatment， the prothrombin time in the clopidogrel hydrogen sulfate group was obviously higher than that in the aspirin group[(12.7±1.6) s vs (11.8±1.8)s]，the difference was statistically significant(t=2.297， P<0.05)， and the activated partial thromboplastin time in the clopidogrel hydrogen sulfate group was obviously higher than that in the aspire group[(41.8±1.6) s vs (37.6±1.7)s]，the difference was statistically significant(t=12.539， P<0.05)， and the total treatment effective rate in the clopidogrel hydrogen sulfate group was obviously higher than that in the aspirin group(93.3% vs 73.3%)，the difference was statistically significant(χ2=7.217， P<0.05)， and the incidence rate of adverse reactions in the clopidogrel hydrogen sulfate group was obviously lower than that in the aspirin group(6.7% vs 23.3%)，the difference was statistically significant(χ2=6.153， P<0.05). Conclusion The clinical effect of clopidogrel hydrogen sulfate in treatment of coronary heart disease is more obvious than that of aspirin， with fewer adverse reactions， and it is worth clinical reference., http://www.100md.com(杨秀清)