盐酸氟桂利嗪与神经生长因子联合应用于脑出血患者中的效果(1)
[摘要] 目的 探讨在常规治疗联合盐酸氟桂利嗪治疗的基础上，加用神经生长因子对脑出血患者的治疗效果，以及对其神经功能的改善作用。 方法 方便选择2017年5月—2018年5月该院收治的脑出血患者92例，以随机数表法将其分为两组，其中对照组46例行常规治疗与盐酸氟桂利嗪治疗，研究组46例在此基础上应用神经生长因子。参照美国国立卫生研究院卒中量表(NIHSS)，评价两组治疗前后神经功能的改善情况、临床疗效与药物不良反应。 结果 采用不同方法治疗后研究组NIHSS评分(5.8±2.0)分、对照组(8.3±2.2)分，均低于治疗前(12.5±2.3)分、(12.6±2.5)分(t=6.203、4.526，P<0.05);其中研究组评分(5.8±2.0)分低于對照组(8.3±2.2)分(t=3.985，P<0.05)。两组治疗总有效率比较中，研究组95.65%高于对照组80.43%(P<0.05)。在药物不良反应比较中，研究组8.70%与对照组8.70%比较差异无统计学意义(P>0.05)。结论 在常规治疗与盐酸氟桂利嗪治疗的基础上，对脑出血患者应用神经生长因子治疗，可以进一步改善其神经功能，效果确切，安全性佳，值得推广。
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[关键词] 盐酸氟桂利嗪;神经生长因子;脑出血;疗效;神经功能
[中图分类号] R743 [文献标识码] A [文章编号] 1674-0742(2019)06(c)-0001-03
[Abstract] Objective To investigate the therapeutic effect of nerve growth factor on patients with cerebral hemorrhage and the improvement of neurological function on the basis of conventional therapy combined with flunarizine hydrochloride. Methods A total of 92 patients with cerebral hemorrhage admitted to our hospital from May 2017 to May 2018 were convenient selected and enrolled in this study. They were divided into two groups by random number table method. Among them， 46 patients in the control group received routine treatment with flunarizine hydrochloride. 46 patients were given nerve growth factor on this basis. Refer to the National Institutes of Health Stroke Scale (NIHSS) to evaluate the improvement of neurological function， clinical efficacy and adverse drug reactions before and after treatment. Results After treatment with different methods， the NIHSS score (5.8±2.0)points and the control group (8.3±2.2)points were lower than those before treatment (12.5±2.3)points and (12.6±2.5)points(t=6.203， 4.526， P<0.05); the study group score (5.8±2.0)points was lower than the control group (8.3±2.2)points(t=3.985， P<0.05). In the comparison of the total effective rate between the two groups， 95.65% in the study group was higher than 80.43% in the control group (P<0.05). In the comparison of adverse drug reactions， there was no significant difference between the study group 8.70% and the control group 8.70% (P>0.05). Conclusion On the basis of conventional treatment and flunarizine hydrochloride treatment， the application of nerve growth factor therapy in patients with cerebral hemorrhage can further improve their neurological function， the effect is clear， the safety is good， and it is worth promoting.
[Key words] Flunarizine hydrochloride; Nerve growth factor; Cerebral hemorrhage; Efficacy; Neurological function, 百拇医药(潘玉红 张胜利)
, http://www.100md.com
[关键词] 盐酸氟桂利嗪;神经生长因子;脑出血;疗效;神经功能
[中图分类号] R743 [文献标识码] A [文章编号] 1674-0742(2019)06(c)-0001-03
[Abstract] Objective To investigate the therapeutic effect of nerve growth factor on patients with cerebral hemorrhage and the improvement of neurological function on the basis of conventional therapy combined with flunarizine hydrochloride. Methods A total of 92 patients with cerebral hemorrhage admitted to our hospital from May 2017 to May 2018 were convenient selected and enrolled in this study. They were divided into two groups by random number table method. Among them， 46 patients in the control group received routine treatment with flunarizine hydrochloride. 46 patients were given nerve growth factor on this basis. Refer to the National Institutes of Health Stroke Scale (NIHSS) to evaluate the improvement of neurological function， clinical efficacy and adverse drug reactions before and after treatment. Results After treatment with different methods， the NIHSS score (5.8±2.0)points and the control group (8.3±2.2)points were lower than those before treatment (12.5±2.3)points and (12.6±2.5)points(t=6.203， 4.526， P<0.05); the study group score (5.8±2.0)points was lower than the control group (8.3±2.2)points(t=3.985， P<0.05). In the comparison of the total effective rate between the two groups， 95.65% in the study group was higher than 80.43% in the control group (P<0.05). In the comparison of adverse drug reactions， there was no significant difference between the study group 8.70% and the control group 8.70% (P>0.05). Conclusion On the basis of conventional treatment and flunarizine hydrochloride treatment， the application of nerve growth factor therapy in patients with cerebral hemorrhage can further improve their neurological function， the effect is clear， the safety is good， and it is worth promoting.
[Key words] Flunarizine hydrochloride; Nerve growth factor; Cerebral hemorrhage; Efficacy; Neurological function, 百拇医药(潘玉红 张胜利)