复方甘草酸苷联合阿德福韦酯应用于治疗慢性乙型肝炎患者的临床效果及对其血清TGF-β1、TNF-α水平的作用评价(1)
[摘要] 目的 探讨在治疗慢性乙型肝炎的过程中应用复方甘草酸苷联合阿德福韦酯的临床效果以及血清TGF-β1、TNF-α水平的变化。 方法 方便收集2016年1月—2018年12月该院收治的慢性乙型肝炎患者80例，随机分为研究组和参照组，每组40例，研究组采用复方甘草酸苷联合阿德福韦酯治疗，参照组采用单纯阿德福韦酯治疗，比较两组的治疗效果，不良反应发生率以及治疗前后血清中TGF-β1、TNF-α水平的变化。 结果 研究组的治疗效果95.00%明显优于参照组，差异有统计学意义(χ2=7.439 7，P<0.05)，不良反应发生率7.50%明显低于参照组，差异有统计学意义(χ2=9.038 3，P<0.05)，治疗1年后血清中TGF-β1(53.28±8.16)μg/mL、TNF-α(4.86±0.57)μg/mL水平明显优于治疗前和参照组，差异有统计学意义(t=12.861 4、10.030 7，P<0.05)。 结论 应用复方甘草酸苷联合阿德福韦酯治疗慢性乙型肝炎效果明显，不良反应少，安全可靠，并且改善患者血清中TGF-β1、TNF-α水平，可在临床推广应用。
[关键词] 慢性乙型肝炎;复方甘草酸苷;阿德福韦酯;不良反应;TGF-β1
[中图分类号] R512 [文献标识码] A [文章编号] 1674-0742(2019)08(c)-0007-03
[Abstract] Objective To investigate the clinical effects of compound glycyrrhizin combined with adefovir dipivoxil and the changes of serum TGF-β1 and TNF-α levels in the treatment of chronic hepatitis B. Methods Eighty patients who were conveiently selected with chronic hepatitis B admitted to this hospital from January 2016 to December 2018 were randomly divided into study group and reference group， 40 patients in each group. The study group used compound glycyrrhizin combined with adefovir treatment， the reference group was treated with adefovir dipivoxil alone， the treatment effect of the two groups， the incidence of adverse reactions and the changes of serum TGF-β1， TNF-α levels before and after treatment. Results The therapeutic effect of the study group was 95.00%， which was significantly better than that of the reference group，the difference was statistically significant(χ2=7.439 7，P<0.05). The incidence of adverse reactions was 7.50% significantly lower than that of the reference group，the difference was statistically significant(χ2=9.038 3，P<0.05). The serum levels of TGF-β1 after 1 year treatment (53.28±8.16)μg/mL and TNF-α (4.86±0.57)μg/mL were significantly better than those before treatment and the reference group，the difference was statistically significant(t=12.861 4，10.030 7，P<0.05). Conclusion The combination of compound glycyrrhizin and adefovir dipivoxil has obvious effects on chronic hepatitis B， less adverse reactions， safe and reliable， and improve the serum levels of TGF-β1 and TNF-α in patients.
[Key words] Chronic hepatitis B; Compound glycyrrhizin; Adefovir dipivoxil; Adverse reactions; TGF-β1
隨着社会老龄化、饮食结构的改变、环境空气污染、乙肝病毒感染、喝酒、肥胖等的患者增多的原因，慢性乙型肝炎的发病率也越来越高。乙型肝炎是一种常见的肝脏疾病，发病率较高，发病时主要表现为食欲不振[1]。随着医学科技的发展提高，以及乙型肝炎疫苗的普及，虽然乙型肝炎的发病情况已经开始下降，但是一旦感染上仍威胁患者的生命健康[2]。乙型肝炎的主要传播为血液和母婴传播等，对于慢性乙型肝炎的治疗主要为药物治疗，因此该研究将2016年1月—2018年12月收治的80例慢性乙型肝炎的患者分为研究组和参照组，分别进行复方甘草酸苷联合阿德福韦酯治疗和阿德福韦酯治疗，比较两组的治疗效果，不良反应发生率以及治疗前后血清中TGF-β1、TNF-α水平的变化，现报道如下。, http://www.100md.com(杨庆余)
[关键词] 慢性乙型肝炎;复方甘草酸苷;阿德福韦酯;不良反应;TGF-β1
[中图分类号] R512 [文献标识码] A [文章编号] 1674-0742(2019)08(c)-0007-03
[Abstract] Objective To investigate the clinical effects of compound glycyrrhizin combined with adefovir dipivoxil and the changes of serum TGF-β1 and TNF-α levels in the treatment of chronic hepatitis B. Methods Eighty patients who were conveiently selected with chronic hepatitis B admitted to this hospital from January 2016 to December 2018 were randomly divided into study group and reference group， 40 patients in each group. The study group used compound glycyrrhizin combined with adefovir treatment， the reference group was treated with adefovir dipivoxil alone， the treatment effect of the two groups， the incidence of adverse reactions and the changes of serum TGF-β1， TNF-α levels before and after treatment. Results The therapeutic effect of the study group was 95.00%， which was significantly better than that of the reference group，the difference was statistically significant(χ2=7.439 7，P<0.05). The incidence of adverse reactions was 7.50% significantly lower than that of the reference group，the difference was statistically significant(χ2=9.038 3，P<0.05). The serum levels of TGF-β1 after 1 year treatment (53.28±8.16)μg/mL and TNF-α (4.86±0.57)μg/mL were significantly better than those before treatment and the reference group，the difference was statistically significant(t=12.861 4，10.030 7，P<0.05). Conclusion The combination of compound glycyrrhizin and adefovir dipivoxil has obvious effects on chronic hepatitis B， less adverse reactions， safe and reliable， and improve the serum levels of TGF-β1 and TNF-α in patients.
[Key words] Chronic hepatitis B; Compound glycyrrhizin; Adefovir dipivoxil; Adverse reactions; TGF-β1
隨着社会老龄化、饮食结构的改变、环境空气污染、乙肝病毒感染、喝酒、肥胖等的患者增多的原因，慢性乙型肝炎的发病率也越来越高。乙型肝炎是一种常见的肝脏疾病，发病率较高，发病时主要表现为食欲不振[1]。随着医学科技的发展提高，以及乙型肝炎疫苗的普及，虽然乙型肝炎的发病情况已经开始下降，但是一旦感染上仍威胁患者的生命健康[2]。乙型肝炎的主要传播为血液和母婴传播等，对于慢性乙型肝炎的治疗主要为药物治疗，因此该研究将2016年1月—2018年12月收治的80例慢性乙型肝炎的患者分为研究组和参照组，分别进行复方甘草酸苷联合阿德福韦酯治疗和阿德福韦酯治疗，比较两组的治疗效果，不良反应发生率以及治疗前后血清中TGF-β1、TNF-α水平的变化，现报道如下。, http://www.100md.com(杨庆余)