喹硫平与奥氮平治疗老年器质性精神障碍的效果对比分析(1)
[摘要] 目的 探討对老年器质性精神障碍患者分别选择喹硫平以及奥氮平药物进行治疗后获得的临床效果。方法 方便选择该院2017年7月—2019年1月收治的104例老年器质性精神障碍患者作为实验对象;随机数表法分组后探讨各组所用药物;对照组(52例)：采用奥氮平药物进行疾病治疗;观察组(52例)：采用喹硫平药物进行疾病治疗;对比用药总有效率、BPRS评分结果、ADL评分结果以及总不良反应。结果 观察组老年器质性精神障碍患者用药总有效率(98.08%)同对照组(94.23%)比较差异无统计学意义(χ2=1.040 0，P>0.05);治疗前，观察组BPRS评分为(49.72±6.29)分，治疗后1周为(35.03±8.43)分，2周为(26.19±6.72)分，4周为(23.39±6.49)分，8周为(20.73±5.65)分，治疗前，对照组BPRS评分为(48.83±7.05)分，治疗后1周为(36.15±7.71)分，2周为(25.75±6.39)分，4周为(23.16±6.23)分，8周为(20.02±5.29)分，观察组老年器质性精神障碍患者BPRS(简明精神病评定量表)评分同对照组比较差异无统计学意义(t=0.679 2、0.706 9、0.342 1、0.184 3、0.661 4，P>0.05);治疗前，观察组ADL评分为(20.96±4.51)分，治疗后1周为(15.19±3.22)分，2周为(14.99±3.29)分，4周为(9.16±3.36)分，8周为(7.73±1.62)分，治疗前，对照组ADL评分为(21.81±4.43)分，治疗后1周为(16.34±3.46)分，2周为(15.35±2.76)分，4周为(15.00±2.79)分，8周为(13.73±2.25)分，用药前、用药1周、2周，观察组老年器质性精神障碍患者ADL(日常生活能力量表)评分同对照组比较差异无统计学意义(t=0.969 5、1.754 5、0.604 5，P>0.05);用药4周、8周，观察组ADL评分低于对照组明显(t=9.642 6、15.605 4，P<0.05);观察组老年器质性精神障碍患者总不良反应发生率(15.38%)同对照组(19.23%)比较差异无统计学意义(χ2=0.268 7，P>0.05)。结论 老年器质性精神障碍患者在接受治疗期间，同奥氮平药物比较，喹硫平药物在用药效果以及症状改善方面，获得效果基本一致，但是在改善生活质量方面，喹硫平应用效果更为显著，从而说明选择喹硫平药物治疗老年器质性精神障碍疾病的可行性。
[关键词] 喹硫平;奥氮平;老年器质性精神障碍;BPRS评分;ADL评分
[中图分类号] R749 [文献标识码] A [文章编号] 1674-0742(2019)09(b)-0110-04
Comparative Analysis of the Effects of Quetiapine and Olanzapine in the Treatment of Elderly Patients with Organic Mental Disorders
FAN Xue-yun
Department of Psychiatry， the Third People's Hospital of Heze City， Heze， Shandong Province， 274000 China
[Abstract] Objective To investigate the clinical effects of quetiapine and olanzapine in elderly patients with organic mental disorders. Methods 104 elderly patients with organic mental disorders admitted to the hospital from July 2017 to January 2019 were conveniently selected as experimental subjects. The drugs used in each group were analyzed by random number table method. The control group (52 cases)： Nitrogen drugs for disease treatment; observation group (52 cases)： treatment with quetiapine for disease treatment; comparison of total medication efficiency， BPRS score， ADL score and total adverse reactions. Results The total effective rate of the elderly patients with organic obstructive disorder (98.08%) was not statistically significantly different from that of the control group (94.23%) (χ2=1.040 0，P>0.05). Before treatment， the BPRS score of the observation group was (49.72±6.29) points， 1 weeks was (35.03±8.43) points after treatment， 2 weeks was (26.19±6.72) points， 4 weeks was (23.39±6.49) points， 8 weeks was (20.73±5.65) points， and the control group had BPRS score before treatment (48.83±7.05) points， 1 weeks after treatment was (36.15±7.71) points， 2 weeks was (25.75±6.39) points， 4 weeks was (23.16±6.23) points， 8 weeks was (20.02±5.29) points， observation group old age BPRS (Concise Psychiatric Rating Scale) scores of patients with qualitative mental disorders were not statistically significantly different from those of the control group(t=0.679 2， 0.706 9， 0.342 1， 0.184 3， 0.661 4，P>0.05). Before treatment， the ADL score of the observation group was (20.96±4.51)points， 1 weeks after treatment was (15.19±3.22)points， 2 weeks was (14.99±3.29)points， 4 weeks was (9.16±3.36)points， and 8 weeks was (7.73±1.62)points. Before treatment， the control group had ADL score of (21.81±4.43) points， 1 weeks after treatment was (16.34±3.46) points， 2 weeks was (15.35±2.76)points， 4 weeks was (15.00±2.79)points， 8 weeks was (13.73±2.25) points， before treatment， 1 weeks， 2 weeks， the ADL (Daily Life Ability Scale) scores of the elderly patients with organic mental disorders were not statistically significantly different from the control group(t=0.969 5， 1.754 5， 0.604 5，P>0.05); 4 weeks， 8 weeks， the ADL score of the observation group was lower than that of the control group(t=9.642 6， 15.605 4，P<0.05); the incidence of total adverse reactions in the elderly patients with organic mental disorder ( 15.38%) was not statistically significantly different from the control group (19.23%) (χ2=0.268 7，P>0.05). Conclusion Compared with olanzapine， quetiapine drugs have the same effect in improving the effect of medication and symptom improvement during the treatment of elderly patients with organic mental disorders. However， the effect of quetiapine is improved in improving the quality of life， indicating the feasibility of choosing quetiapine drugs for the treatment of elderly patients with organic mental disorders., 百拇医药(范雪云)
[关键词] 喹硫平;奥氮平;老年器质性精神障碍;BPRS评分;ADL评分
[中图分类号] R749 [文献标识码] A [文章编号] 1674-0742(2019)09(b)-0110-04
Comparative Analysis of the Effects of Quetiapine and Olanzapine in the Treatment of Elderly Patients with Organic Mental Disorders
FAN Xue-yun
Department of Psychiatry， the Third People's Hospital of Heze City， Heze， Shandong Province， 274000 China
[Abstract] Objective To investigate the clinical effects of quetiapine and olanzapine in elderly patients with organic mental disorders. Methods 104 elderly patients with organic mental disorders admitted to the hospital from July 2017 to January 2019 were conveniently selected as experimental subjects. The drugs used in each group were analyzed by random number table method. The control group (52 cases)： Nitrogen drugs for disease treatment; observation group (52 cases)： treatment with quetiapine for disease treatment; comparison of total medication efficiency， BPRS score， ADL score and total adverse reactions. Results The total effective rate of the elderly patients with organic obstructive disorder (98.08%) was not statistically significantly different from that of the control group (94.23%) (χ2=1.040 0，P>0.05). Before treatment， the BPRS score of the observation group was (49.72±6.29) points， 1 weeks was (35.03±8.43) points after treatment， 2 weeks was (26.19±6.72) points， 4 weeks was (23.39±6.49) points， 8 weeks was (20.73±5.65) points， and the control group had BPRS score before treatment (48.83±7.05) points， 1 weeks after treatment was (36.15±7.71) points， 2 weeks was (25.75±6.39) points， 4 weeks was (23.16±6.23) points， 8 weeks was (20.02±5.29) points， observation group old age BPRS (Concise Psychiatric Rating Scale) scores of patients with qualitative mental disorders were not statistically significantly different from those of the control group(t=0.679 2， 0.706 9， 0.342 1， 0.184 3， 0.661 4，P>0.05). Before treatment， the ADL score of the observation group was (20.96±4.51)points， 1 weeks after treatment was (15.19±3.22)points， 2 weeks was (14.99±3.29)points， 4 weeks was (9.16±3.36)points， and 8 weeks was (7.73±1.62)points. Before treatment， the control group had ADL score of (21.81±4.43) points， 1 weeks after treatment was (16.34±3.46) points， 2 weeks was (15.35±2.76)points， 4 weeks was (15.00±2.79)points， 8 weeks was (13.73±2.25) points， before treatment， 1 weeks， 2 weeks， the ADL (Daily Life Ability Scale) scores of the elderly patients with organic mental disorders were not statistically significantly different from the control group(t=0.969 5， 1.754 5， 0.604 5，P>0.05); 4 weeks， 8 weeks， the ADL score of the observation group was lower than that of the control group(t=9.642 6， 15.605 4，P<0.05); the incidence of total adverse reactions in the elderly patients with organic mental disorder ( 15.38%) was not statistically significantly different from the control group (19.23%) (χ2=0.268 7，P>0.05). Conclusion Compared with olanzapine， quetiapine drugs have the same effect in improving the effect of medication and symptom improvement during the treatment of elderly patients with organic mental disorders. However， the effect of quetiapine is improved in improving the quality of life， indicating the feasibility of choosing quetiapine drugs for the treatment of elderly patients with organic mental disorders., 百拇医药(范雪云)