沙丁胺醇联合布地奈德治疗小儿哮喘急性发作效果分析(1)
[摘要] 目的 分析对小儿哮喘急性发作患儿采用沙丁胺醇联合布地奈德治疗的临床疗效。方法 方便选择该院2015年12月—2018年12月于此时间段内进行治疗的小儿哮喘急性发作患儿共计86例，将所有患儿根据不同的治疗方法，随机分为2个治疗小组，分别为对照组(43例，仅使用沙丁胺醇治疗)，观察组(43例，采用沙丁胺醇联合布地奈德治疗)，对两组的治疗效果进行收集和分析。结果 观察组的总有效率(97.67%)、FEV1(3.14±0.67)L、FVC(4.19±0.48)L、PEF值(239.05±28.16)L/min、肺部哮鸣音消失人数比(88.37%)和喘息消失人数比(83.72%)均优于对照组总有效率(83.72%)、FEV1(2.49±0.52)L、FVC(3.28±0.40)L、PEF值(271.40±31.41)L/min、肺部哮鸣音消失人数比(48.84%)和喘息消失人数比(53.49%)，差异有统计学意义(χ2=4.962，P=0.030;t=5.026、9.550、5.029，P=0.001、0.001、0.001;χ2=15.600、9.120，P=0.001、0.003)。 结论 在对小儿哮喘急性发作患者实施临床治疗时，应用沙丁胺醇联合布地奈德治疗，能够取得更佳的效果，疗效显著，有较高的使用价值，值得推广。
[关键词] 沙丁胺醇;布地奈德;小儿哮喘急性发作;临床疗效
[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742(2019)12(c)-0097-03
Effect of Salbutamol Combined with Budesonide on Acute Asthma Attack in Children
ZHOU Bi-bao
Department of Pediatrics， Maternal and Child Health Hospital， Jianyang District， Nanping， Fujian Province， 354200 China
[Abstract] Objective To analyze the clinical efficacy of salbutamol combined with budesonide in children with acute asthma attack. Methods Convenient select a total of 86 children with acute asthma attacks in our hospital from December 2015 to December 2018 were selected. All children were randomLy divided into two treatment groups according to different treatment methods. The control group (43 patients， only treated with salbutamol) and the observation group (43 patients treated with salbutamol combined with budesonide) were collected and analyzed. Results The total effective rate (97.67%)， FEV1 (3.14±0.67)L， FVC (4.19±0.48)L， PEF value (239.05±28.16)L/min， lung wheezing disappearance ratio (88.37%) and wheezing disappearance ratio in the observation group (83.72%) was better than the total effective rate of the control group (83.72%)， FEV1 (2.49±0.52)L， FVC (3.28±0.40)L， PEF value (271.40±31.41)L/min， and the proportion of lung wheezing disappearance (48.84%) and the rate of wheezing disappearance (53.49%)， the difference was statistically significant (χ2=4.962， P=0.030; t=5.026，9.550，5.029， P=0.001，0.001，0.001; χ2=15.600，9.120， P=0.001，0.003). Conclusion In the clinical treatment of children with acute asthma attack， the application of salbutamol combined with budesonide can achieve better results， significant curative effect， high use value， and worth promoting.
[Key words] Salbutamol; Budesonide; Acute asthma attack in children; Clinical efficacy
小儿哮喘是属于儿科呼吸系统常见的慢性疾病，病情发作时，患儿可出现喘息、咳嗽、气促、胸闷，严重的甚至脸色苍白、气短，呼吸困难以及说话不能连续[1]。就目前情況而言，临床上缺乏根治哮喘的有效方法，故此，控制急性发作是治疗小儿哮喘的重要目标[2]。若哮喘急性发作未能及时有效的治疗，症状不能有效缓解是非常危险的，在哮喘持续状态下，患儿可能并发呼吸衰竭和心力衰竭导致休克、死亡[3]。因此，对小儿哮喘急性发作采用更有效治疗方法受到重视。该研究中选取2015年12月—2018年12月收治的小儿哮喘急性发作患儿共计86例，并主要集中分析使用沙丁胺醇与布地奈德混悬液雾化吸入治疗联合应用的临床效果，报道如下。, http://www.100md.com(周必宝)
[关键词] 沙丁胺醇;布地奈德;小儿哮喘急性发作;临床疗效
[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742(2019)12(c)-0097-03
Effect of Salbutamol Combined with Budesonide on Acute Asthma Attack in Children
ZHOU Bi-bao
Department of Pediatrics， Maternal and Child Health Hospital， Jianyang District， Nanping， Fujian Province， 354200 China
[Abstract] Objective To analyze the clinical efficacy of salbutamol combined with budesonide in children with acute asthma attack. Methods Convenient select a total of 86 children with acute asthma attacks in our hospital from December 2015 to December 2018 were selected. All children were randomLy divided into two treatment groups according to different treatment methods. The control group (43 patients， only treated with salbutamol) and the observation group (43 patients treated with salbutamol combined with budesonide) were collected and analyzed. Results The total effective rate (97.67%)， FEV1 (3.14±0.67)L， FVC (4.19±0.48)L， PEF value (239.05±28.16)L/min， lung wheezing disappearance ratio (88.37%) and wheezing disappearance ratio in the observation group (83.72%) was better than the total effective rate of the control group (83.72%)， FEV1 (2.49±0.52)L， FVC (3.28±0.40)L， PEF value (271.40±31.41)L/min， and the proportion of lung wheezing disappearance (48.84%) and the rate of wheezing disappearance (53.49%)， the difference was statistically significant (χ2=4.962， P=0.030; t=5.026，9.550，5.029， P=0.001，0.001，0.001; χ2=15.600，9.120， P=0.001，0.003). Conclusion In the clinical treatment of children with acute asthma attack， the application of salbutamol combined with budesonide can achieve better results， significant curative effect， high use value， and worth promoting.
[Key words] Salbutamol; Budesonide; Acute asthma attack in children; Clinical efficacy
小儿哮喘是属于儿科呼吸系统常见的慢性疾病，病情发作时，患儿可出现喘息、咳嗽、气促、胸闷，严重的甚至脸色苍白、气短，呼吸困难以及说话不能连续[1]。就目前情況而言，临床上缺乏根治哮喘的有效方法，故此，控制急性发作是治疗小儿哮喘的重要目标[2]。若哮喘急性发作未能及时有效的治疗，症状不能有效缓解是非常危险的，在哮喘持续状态下，患儿可能并发呼吸衰竭和心力衰竭导致休克、死亡[3]。因此，对小儿哮喘急性发作采用更有效治疗方法受到重视。该研究中选取2015年12月—2018年12月收治的小儿哮喘急性发作患儿共计86例，并主要集中分析使用沙丁胺醇与布地奈德混悬液雾化吸入治疗联合应用的临床效果，报道如下。, http://www.100md.com(周必宝)