正清风痛宁降低类风湿关节炎患者病情活动性临床研究(1)

http://www.100md.com 2020年2月5日 《中外医疗》 20204

     [摘要] 目的 研究类风湿关节炎患者临床接受正清风痛宁治疗对于病情活动性的改善效果。 方法 随机将方便选取该院2017年4月—2019年1月类风湿关节炎75例住院患者分为两组，观察组40例、对照组35例，对照组接受甲氨蝶呤、来氟米特常规治疗，观察组在对照组用药之外联合正清风痛宁治疗，比较两组治疗效果。结果 观察组治疗后低活动性率为42.50%，高活动性率为27.50%，优于对照组20.00%、51.43%(χ2=4.343、4.507，P<0.05);观察组治疗后血沉、C反应蛋白、类风湿因子水平低于对照组(P<0.05)，观察组不良反应发生率12.50%低于对照组17.14%，但差异无统计学意义(χ2=0.322，P>0.05)。 结论 在类风湿关节炎治疗中应用正清风痛宁有助于减轻患者病情活动性，更有效控制炎症水平，应用价值明显。

    [关键词] 类风湿关节炎;正清风痛宁;治疗;病情活动性

    [中图分类号] R259 [文献标识码] A [文章编号] 1674-0742(2020)02(a)-0098-03

    Clinical Study on the Effect of Zhengqing Fengtongning on the Disease Activity of Patients with Rheumatoid Arthritis

    ZHANG Li

    Department of Rheumatology and Immunology， People's Hospital of Xinyi City， Xinyi， Jiangsu Province， 221400 China

    [Abstract] Objective To study the effect of patients with rheumatoid arthritis(RA)on the improvement of the activity of patients with positive Zhengqing Fengtongning. Methods Convenient selection of 75 hospitalized patients with rheumatoid arthritis in the hospital from April 2017 to January 2019 were randomly divided into two groups： the observation group (40 cases) and the control group (35 cases). The control group received conventional treatment with methotrexate and leflunomide. Results After treatment， the low activity rate and high activity rate of the observation group were 42.50% and 27.50%， which were better than the control group 20.00% and 51.43%(χ2=4.343，4.507，P<0.05). After treatment， the levels of serum sedimentation rate， c-reactive protein and rheumatoid factor in the observation group were lower than those in the control group(P<0.05)， and the incidence of adverse reactions was 12.50% in the observation group，which was lower than 17.14% in the control group，and the difference was statistically significant(χ2=0.322， P>0.05). Conclusion The application of Zhengqing Fengtongning in the treatment of rheumatoid arthritis is helpful to reduce the activity of the patient and control the inflammatory level more effectively， and the application value is obvious.

    [Key words] Rheumatoid Arthritis; Zhengqing Fengtongning; Treatment; Illness Activity

    類风湿关节炎属于一类慢性炎症性疾病，以关节为主要发病位，研究证实疾病的发生和自身免疫存在相关性[1]。直至当前临床也没有完全明确类风湿关节炎的病因，更多的处理方法是在病发后积极用药[2]。甲氨蝶呤这类抗风湿药在临床应用证实有良好效果，能够对病情进展形成阻碍，同时能够使关节功能得以维持，不过这类药物也有明显的不良反应，使得部分患者无法坚持按疗程用药，整体治疗效果受到影响[3-4]。该院在常规西药治疗基础上联合应用中药制剂正清风痛宁，取得了良好效果，现以该院2017年4月—2019年1月75例住院患者为对象展开研究，现将结果报道如下。

    1 对象与方法, http://www.100md.com(张莉)

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