腹腔镜术与开腹手术治疗结肠癌的近期、远期疗效比较研究(1)
[摘要] 目的 比较腹腔镜术与开腹手术治疗结肠癌的近期、远期疗效。方法 方便选择2011年1月—2013年12月于该院就诊的结肠癌患者62例，采用随机数字表法将患者分为A组与B组，两组患者均为31例。A组患者采用腹腔镜术治疗，B组患者采用开腹手术治疗，比较两组患者的近、远期疗效。结果 A组患者的近期疗效相关指标显著优B组，两组比较差异有统计学意义(P<0.05)。治疗后，A组患者的IL-5(2.75±0.28)pg/mL、IL-8(11.38±1.59)pg/mL、TNF-α(1.49±0.16)ng/mL水平显著低于B组，差异有统计学意义(P<0.05)。A组患者的3年(67.74%)、5年(48.39%)生存率显著高于B组，转移复发率显著低于B组，两组比较差异有统计学意义(P<0.05)。结论 腹腔镜术治疗结肠癌的创伤小，患者恢复快，近期、远期疗效均良好，值得推荐。
[关键词] 结肠癌;腹腔镜术;开腹手术;近期疗效;远期疗效
[Abstract] Objective To compare the short-term and long-term effects of laparoscopy and open surgery on colon cancer. Methods Sixty-two patients with colon cancer treated in the hospital from January 2011 to December 2013 were conveniently selected， and the patients were divided into group A and group B by random number table method， with 31 patients in both groups. Patients in group A were treated with laparoscopy， and patients in group B were treated with open surgery. The short-term and long-term effects of the two groups were compared. Results The short-term efficacy-related indicators of patients in group A were significantly better than those in group B， and the difference between the two groups was statistically significant(P<0.05). After treatment， the levels of IL-5 (2.75±0.28)pg/mL， IL-8 (11.38±1.59)pg/mL， and TNF-α(1.49±0.16) ng/mL in group A were significantly lower than those in group B， the difference was statistically significant(P<0.05). The 3-year(67.74%) and 5-year(48.39%) survival rates of group A patients were significantly higher than those of group B， and the recurrence rate of metastasis was significantly lower than that of group B. The difference between the two groups was statistically significant(P<0.05). Conclusion Laparoscopic surgery for colon cancer is less invasive， and the patient recovers quickly. The short-term and long-term effects are good， and it is worth recommending.
[Key words] Colon cancer; Laparoscopy; Open surgery; Short-term effect; Long-term effect
結肠癌是临床上比较常见的消化道恶性肿瘤，其发生于直肠和乙状结肠交界处，多为40～50岁的人群，男性与女性比例为2～3∶1[1]。结肠癌的恶性肿瘤较高，临床上多采用外科手术治疗[2]。目前常用的手术手段主要有开腹手术与腹腔镜手术，两种手术各有优势和局限[3]。因此，该研究方便选择2011年1月—2013年12月于该院就诊的结肠癌患者62例，比较腹腔镜术与开腹手术治疗结肠癌的近期、远期疗效，现报道如下。
1 资料与方法
1.1 一般资料
经医学伦理委员会同意，方便选取于该院就诊的结肠癌患者62例，采用随机数字表法将患者分为A组与B组，两组患者均为31例。纳入标准：①均经影像学、病理学检查证实，符合结肠癌的诊断标准[4];②无远处转移者;③签署知情同意书。排除标准：①合并严重器质性疾病者;②合并免疫系统疾病者;③合并凝血系统疾病者;④合并精神障碍者;⑤合并其他恶性肿瘤者;⑥中途失访者。A组：男17例，女14例;年龄45～77岁，平均(58.62±4.33)岁;TNM分期：I期11例，II期14例，III期6例。B组：男18例，女13例;年龄43～75岁，平均(58.40±4.19)岁;TNM分期：I期8例，II期15例，III期8例。两组基础资料对比差异无统计学意义(P>0.05)，均衡可比。, http://www.100md.com(张鑫宇)
[关键词] 结肠癌;腹腔镜术;开腹手术;近期疗效;远期疗效
[Abstract] Objective To compare the short-term and long-term effects of laparoscopy and open surgery on colon cancer. Methods Sixty-two patients with colon cancer treated in the hospital from January 2011 to December 2013 were conveniently selected， and the patients were divided into group A and group B by random number table method， with 31 patients in both groups. Patients in group A were treated with laparoscopy， and patients in group B were treated with open surgery. The short-term and long-term effects of the two groups were compared. Results The short-term efficacy-related indicators of patients in group A were significantly better than those in group B， and the difference between the two groups was statistically significant(P<0.05). After treatment， the levels of IL-5 (2.75±0.28)pg/mL， IL-8 (11.38±1.59)pg/mL， and TNF-α(1.49±0.16) ng/mL in group A were significantly lower than those in group B， the difference was statistically significant(P<0.05). The 3-year(67.74%) and 5-year(48.39%) survival rates of group A patients were significantly higher than those of group B， and the recurrence rate of metastasis was significantly lower than that of group B. The difference between the two groups was statistically significant(P<0.05). Conclusion Laparoscopic surgery for colon cancer is less invasive， and the patient recovers quickly. The short-term and long-term effects are good， and it is worth recommending.
[Key words] Colon cancer; Laparoscopy; Open surgery; Short-term effect; Long-term effect
結肠癌是临床上比较常见的消化道恶性肿瘤，其发生于直肠和乙状结肠交界处，多为40～50岁的人群，男性与女性比例为2～3∶1[1]。结肠癌的恶性肿瘤较高，临床上多采用外科手术治疗[2]。目前常用的手术手段主要有开腹手术与腹腔镜手术，两种手术各有优势和局限[3]。因此，该研究方便选择2011年1月—2013年12月于该院就诊的结肠癌患者62例，比较腹腔镜术与开腹手术治疗结肠癌的近期、远期疗效，现报道如下。
1 资料与方法
1.1 一般资料
经医学伦理委员会同意，方便选取于该院就诊的结肠癌患者62例，采用随机数字表法将患者分为A组与B组，两组患者均为31例。纳入标准：①均经影像学、病理学检查证实，符合结肠癌的诊断标准[4];②无远处转移者;③签署知情同意书。排除标准：①合并严重器质性疾病者;②合并免疫系统疾病者;③合并凝血系统疾病者;④合并精神障碍者;⑤合并其他恶性肿瘤者;⑥中途失访者。A组：男17例，女14例;年龄45～77岁，平均(58.62±4.33)岁;TNM分期：I期11例，II期14例，III期6例。B组：男18例，女13例;年龄43～75岁，平均(58.40±4.19)岁;TNM分期：I期8例，II期15例，III期8例。两组基础资料对比差异无统计学意义(P>0.05)，均衡可比。, http://www.100md.com(张鑫宇)
参见：首页 > 医疗版 > 疾病专题 > 消化内科 > 肠道疾病 > 类癌及类癌综合征 > 结、直肠癌