乌梅汤加减联合盐酸二甲双胍治疗2型糖尿病临床疗效及安全性研究(1)
[摘要] 目的 探究2型糖尿病患者应用乌梅汤加减与盐酸二甲双胍联合治疗效果情况。方法 方便选取2018年10月—2019年10月在该院收治的80例2型糖尿病患者，随机分为两组，每组40例。对照组给予盐酸二甲双胍治疗，观察组在对照组基础给予乌梅汤加减治疗。将两组临床血糖指标及不良反应进行记录和对比。结果 观察组HbAlc(6.13±0.60)%、FPG(6.23±0.25)mmol/L、2 hPG(8.02±1.03)mmol/L等临床血糖指标均低于对照组，差异有统计学意义(t=5.579、9.900、4.816，P<0.05);观察组中医症候评分(4.23±0.65)分比对照组低，差异有统计学意义(t=11.077，P<0.05);观察组不良反应率为5.00%低于对照组，差异有统计学意义(χ2=4.114，P<0.05)。结论 2型糖尿病患者应用乌梅汤加减与盐酸二甲双胍联合治疗，能够显著调控患者血糖指标，有效降低不良反应发生，安全性更高。
[关键词] 乌梅汤加减;2型糖尿病;盐酸二甲双胍;临床效果;血糖;不良反应
[中图分类号] R587 [文献标识码] A [文章编号] 1674-0742(2020)08(b)-0018-03
Study on the Clinical Efficacy and Safety of Ume Soup Plus or Minus Combined with Metformin Hydrochloride in the Treatment of Type 2 Diabetes Mellitus
XIU Hao， GAO Jian， LU Shun
Department of Traditional Chinese Medicine， Ninth People's Hospital of Qingdao， Qingdao， Shandong Province， 266000 China
[Abstract] Objective To explore the effect of combined treatment of ume soup and metformin hydrochloride in patients with type 2 diabetes. Methods 80 patients with type 2 diabetes admitted in the hospital from October 2018 to October 2019 were randomly divided into two groups， 40 in each group. The control group was convenient treated with metformin hydrochloride， and the observation group was given ume soup on the basis of the control group. After the addition and subtraction treatment， the clinical blood glucose indexes and adverse reactions of the two groups were recorded and compared. Results Observation group HbAlc (6.13±0.60)%， FPG(6.23±0.25)mmol/L， 2 hPG(8.02±1.03) mmol/L and other clinical blood glucose indicators were lower than the control group，the difference was statistically significant(t=5.579，9.900，4.816，P<0.05); the observation group's TCM symptom score (4.23±0.65) points is lower than that of the control group，the difference was statistically significant(t=11.077，P<0.05); the adverse reaction rate of the observation group was 5.00% lower than that of the control group，the difference was statistically significant(χ2=4.114，P<0.05). Conclusion The combined treatment of ume soup and metformin hydrochloride in patients with type 2 diabetes can significantly regulate the blood glucose index of patients， effectively reduce the occurrence of adverse reactions， and have higher safety.
[Key words] Ume soup; Type 2 diabetes; Metformin hydrochloride; Clinical effect; Blood glucose; Adverse reactions
隨社会发展，人们生活方式及饮食习惯逐渐改变，2型糖尿病发病率逐年攀升，中老年是疾病高发人群[1-2]。从疾病初期的胰岛素抵抗为主伴胰岛素相对分泌不足，到疾病后期的胰岛素分泌绝对不足为主，胰岛功能衰竭、胰岛素抵抗为本病主要病理生理变化，多饮、多尿、多食和体重降低是临床常见症状。目前，盐酸二甲双胍片是临床一线治疗方案，而单用二甲双胍又难以达到预期疗效[3-4]。乌梅汤为《伤寒论》之乌梅丸由丸剂化裁为汤剂而成，原方治蛔厥，但该方组方精妙，全方缓肝调中，清上温下，生津止渴，现代医家有应用该方加减治疗糖尿病，取得一定疗效，故该次研究以乌梅丸为基础进行加减[5-6]。因此，该文探究2018年10月—2019年10月在该院收治2型糖尿病40例患者应用乌梅汤加减联合盐酸二甲双胍治疗对临床治疗效果的影响，现报道如下。, 百拇医药(修浩 高健 陆顺)
[关键词] 乌梅汤加减;2型糖尿病;盐酸二甲双胍;临床效果;血糖;不良反应
[中图分类号] R587 [文献标识码] A [文章编号] 1674-0742(2020)08(b)-0018-03
Study on the Clinical Efficacy and Safety of Ume Soup Plus or Minus Combined with Metformin Hydrochloride in the Treatment of Type 2 Diabetes Mellitus
XIU Hao， GAO Jian， LU Shun
Department of Traditional Chinese Medicine， Ninth People's Hospital of Qingdao， Qingdao， Shandong Province， 266000 China
[Abstract] Objective To explore the effect of combined treatment of ume soup and metformin hydrochloride in patients with type 2 diabetes. Methods 80 patients with type 2 diabetes admitted in the hospital from October 2018 to October 2019 were randomly divided into two groups， 40 in each group. The control group was convenient treated with metformin hydrochloride， and the observation group was given ume soup on the basis of the control group. After the addition and subtraction treatment， the clinical blood glucose indexes and adverse reactions of the two groups were recorded and compared. Results Observation group HbAlc (6.13±0.60)%， FPG(6.23±0.25)mmol/L， 2 hPG(8.02±1.03) mmol/L and other clinical blood glucose indicators were lower than the control group，the difference was statistically significant(t=5.579，9.900，4.816，P<0.05); the observation group's TCM symptom score (4.23±0.65) points is lower than that of the control group，the difference was statistically significant(t=11.077，P<0.05); the adverse reaction rate of the observation group was 5.00% lower than that of the control group，the difference was statistically significant(χ2=4.114，P<0.05). Conclusion The combined treatment of ume soup and metformin hydrochloride in patients with type 2 diabetes can significantly regulate the blood glucose index of patients， effectively reduce the occurrence of adverse reactions， and have higher safety.
[Key words] Ume soup; Type 2 diabetes; Metformin hydrochloride; Clinical effect; Blood glucose; Adverse reactions
隨社会发展，人们生活方式及饮食习惯逐渐改变，2型糖尿病发病率逐年攀升，中老年是疾病高发人群[1-2]。从疾病初期的胰岛素抵抗为主伴胰岛素相对分泌不足，到疾病后期的胰岛素分泌绝对不足为主，胰岛功能衰竭、胰岛素抵抗为本病主要病理生理变化，多饮、多尿、多食和体重降低是临床常见症状。目前，盐酸二甲双胍片是临床一线治疗方案，而单用二甲双胍又难以达到预期疗效[3-4]。乌梅汤为《伤寒论》之乌梅丸由丸剂化裁为汤剂而成，原方治蛔厥，但该方组方精妙，全方缓肝调中，清上温下，生津止渴，现代医家有应用该方加减治疗糖尿病，取得一定疗效，故该次研究以乌梅丸为基础进行加减[5-6]。因此，该文探究2018年10月—2019年10月在该院收治2型糖尿病40例患者应用乌梅汤加减联合盐酸二甲双胍治疗对临床治疗效果的影响，现报道如下。, 百拇医药(修浩 高健 陆顺)