阿司匹林联合氯吡格雷治疗脑梗死患者临床疗效及神经功能分析(1)
[摘要] 目的 分析阿司匹林联合氯吡格雷治疗脑梗死患者临床疗效及神经功能分析。 方法 便利选择2018年10月—2019年8月该院收治脑梗死患者88例，按随机数表分为两组，对照组44例给予阿司匹林治疗，研究组44例采用阿司匹林联合氯吡格雷治疗，对两组临床疗效、神经功能及不良反应发生情况进行比较。 结果 对照组总有效率明显低于研究组93.18%(41/44)，差异有统计学意义(χ2=5.436， P<0.05);研究组患者神经功能评分为(8.44±1.25)分比对照组(10.13±2.34)分低，比较差异有统计意义(t=4.226， P<0.05);研究组患者结膜出血、胃肠道出血、恶心呕吐等不良反应发生率为6.81%，低于对照组22.72%，差异有统计学意义(χ2=4.423， P<0.05)。 结论 脑梗死患者使用阿司匹林联合氯吡格雷治疗，能改善患者神经功能，减少不良反应发生，还能进一步提高其治疗效果，临床上值得推广使用。
[关键词] 阿司匹林;氯吡格雷;脑梗死;临床疗效;神经功能
[中图分类号] R743 [文献标识码] A [文章编号] 1674-0742(2020)08(b)-0021-03
Analysis of Clinical Efficacy and Nerve Function Of Aspirin Combined with Clopidogrel in Patients with Cerebral Infarction
WANG Ling-chen
Department of Neurology， Yanggu County People's Hospital，Liaocheng， Shandong Province， 252300 China
[Abstract] Objective To analyze the clinical efficacy and neurological analysis of aspirin combined with clopidogrel in the treatment of patients with cerebral infarction. Methods From October 2018 to August 2019， 88 patients with cerebral infarction were convenient selected and divided into two groups according to the random number table. 44 patients in the control group were treated with aspirin， and 44 patients in the study group were treated with aspirin and clopidogrel. The clinical efficacy， neurological function and adverse reactions of the two groups were compared. Results The total effective rate of the control group was significantly lower than that of the study group 93.18% (41/44)， the difference was statistically significant (χ2=5.436， P<0.05); the neurological function score of the study group was(8.44±1.25)points was lower compared with the control group (10.13±2.34)points， the difference was statistically significant(t=4.226， P<0.05); the incidence of adverse reactions such as conjunctival hemorrhage， gastrointestinal bleeding， nausea and vomiting in the study group was 6.81%， which was lower than the control group 22.72%，the difference was statistically significant(χ2=4.423， P<0.05). Conclusion The use of aspirin combined with clopidogrel in patients with cerebral infarction can improve the patient's neurological function， reduce the occurrence of adverse reactions， and further improve its therapeutic effect.
[Key words] Aspirin; Clopidogrel; Cerebral infarction; Clinical efficacy; Nerve function
腦梗死在临床上属于一种常见危重症疾病，其具有较高的发病率、致残率及致死率，多数患者常并有冠心病、高血脂、糖尿病等病症[1]。脑梗死疾病包括有不同的疾病类型，如腔隙性梗死、脑血栓、脑栓塞等，发病不受年龄所限制，具有发病急、进展快、病情危重及预后差等特点。一旦发生脑梗死，未及时接受有效治疗，不仅会影响患者神经系统及认知功能，还会对其肢体功能带来严重影响，进而引发一系列的继发症状[2]。近年来，由于我国社会经济飞速发展，人们生活习惯与饮食结构发生极大改变，加上我国社会人口老龄化日益加重，导致该疾病发病率明显呈逐年上升趋势，严重影响患者日常生活以及身心健康[3]。该研究针对该院2018年10月—2019年8月收治的脑梗死患者88例采取不同治疗方案给予分析，现报道如下。, 百拇医药(王凌晨)
[关键词] 阿司匹林;氯吡格雷;脑梗死;临床疗效;神经功能
[中图分类号] R743 [文献标识码] A [文章编号] 1674-0742(2020)08(b)-0021-03
Analysis of Clinical Efficacy and Nerve Function Of Aspirin Combined with Clopidogrel in Patients with Cerebral Infarction
WANG Ling-chen
Department of Neurology， Yanggu County People's Hospital，Liaocheng， Shandong Province， 252300 China
[Abstract] Objective To analyze the clinical efficacy and neurological analysis of aspirin combined with clopidogrel in the treatment of patients with cerebral infarction. Methods From October 2018 to August 2019， 88 patients with cerebral infarction were convenient selected and divided into two groups according to the random number table. 44 patients in the control group were treated with aspirin， and 44 patients in the study group were treated with aspirin and clopidogrel. The clinical efficacy， neurological function and adverse reactions of the two groups were compared. Results The total effective rate of the control group was significantly lower than that of the study group 93.18% (41/44)， the difference was statistically significant (χ2=5.436， P<0.05); the neurological function score of the study group was(8.44±1.25)points was lower compared with the control group (10.13±2.34)points， the difference was statistically significant(t=4.226， P<0.05); the incidence of adverse reactions such as conjunctival hemorrhage， gastrointestinal bleeding， nausea and vomiting in the study group was 6.81%， which was lower than the control group 22.72%，the difference was statistically significant(χ2=4.423， P<0.05). Conclusion The use of aspirin combined with clopidogrel in patients with cerebral infarction can improve the patient's neurological function， reduce the occurrence of adverse reactions， and further improve its therapeutic effect.
[Key words] Aspirin; Clopidogrel; Cerebral infarction; Clinical efficacy; Nerve function
腦梗死在临床上属于一种常见危重症疾病，其具有较高的发病率、致残率及致死率，多数患者常并有冠心病、高血脂、糖尿病等病症[1]。脑梗死疾病包括有不同的疾病类型，如腔隙性梗死、脑血栓、脑栓塞等，发病不受年龄所限制，具有发病急、进展快、病情危重及预后差等特点。一旦发生脑梗死，未及时接受有效治疗，不仅会影响患者神经系统及认知功能，还会对其肢体功能带来严重影响，进而引发一系列的继发症状[2]。近年来，由于我国社会经济飞速发展，人们生活习惯与饮食结构发生极大改变，加上我国社会人口老龄化日益加重，导致该疾病发病率明显呈逐年上升趋势，严重影响患者日常生活以及身心健康[3]。该研究针对该院2018年10月—2019年8月收治的脑梗死患者88例采取不同治疗方案给予分析，现报道如下。, 百拇医药(王凌晨)