不同炮制方法对中药远志药效的影响(1)
[摘要] 目的 分析不同炮制方法对中药远志药效的影响。方法 于2018年1—6月期间选取50只小鼠自发活动计数法对不同炮制方法的中药远志镇静效果进行对比;采用氨水引咳、气管段酚红的方式对比不同炮制方法的中药远志镇咳和化痰效果。结果 通过不同炮制方法对比，在活动次数方面，对照组与生远志组(t=12.796，P=0.001)，与蜜远志组(t=10.731，P=0.001)，与制远志组(t=13.348，P=0.001)，对照组与生远志组、蜜远志组以及制远志组的镇静效果差异有统计学意义(P<0.05);在入眠时间方面、对照组与生远志组(t=2.681，P=0.015)，与蜜远志组(t=2.688，P=0.015)，与制远志组(t=3.727，P=0.002)，与戊巴比妥钠组(t=6.149，P=0.001)，对照组与生远志组、蜜远志组以及制远志组的催眠效果，差异有统计学意义(P<0.05);在咳嗽次数方面，对照组与生远志组(t=3.011，P=0.008)，与蜜远志组(t=2.413，P=0.027)，与制远志组(t=1.941，P=0.068)，與可待因药组(t=6.656，P=0.001)，对照组与生远志组、蜜远志组以及可待因药组止咳效果，差异有统计学意义(P<0.05);对照组与生远志组、蜜远志组、制远志组、可待因药组止咳效果比较，差异无统计学意义(P>0.05)。 结论 通过不同的炮制方法，中药远志药效的差别相对较大，在临床中可根据患者的实际情况合理应用。
[关键词] 中药;远志;炮制方法
[中图分类号] R283 [文献标识码] A [文章编号] 1674-0742(2020)09(c)-0178-03
[Abstract] Objective To analyze the effects of different processing methods on the efficacy of Chinese medicine Yuanzhi. Methods From January 2018 to June， the spontaneous activity counting method of 50 mice was selected to compare the sedative effects of different processing methods of Chinese medicine Yuanzhi; the methods of cough induced by ammonia and phenol red in the trachea were compared with different processing methods of the antitussive and phlegm effect of Chinese medicine Yuanzhi. Results Through the comparison of different processing methods， in terms of number of activities， the control group and the Shengyuanzhi group (t=12.796， P=0.001)， and the Miyuanzhi group (t=10.731， P=0.001)， and the Zhiyuanzhi group (t=13.348， P=0.001)， The sedative effects of the control group and the Shengyuanzhi group， the Miyuanzhi group， and the Zhiyuanzhi group，the difference was statistically significant(P<0.05); in terms of sleep time， the control group and the Shengyuanzhi group (t=2.681， P=0.015)， and the honeyyuanzhi group (t=2.688， P=0.015)， with the Zhiyuanzhi group (t=3.727， P=0.002)， with the sodium pentobarbital group (t=6.149， P=0.001)， the control group with the Shengyuanzhi group， the Miyuanzhi group， and the Zhiyuanzhi group The difference in hypnotic effect was statistically significant(P<0.05); in terms of the number of coughs the control group and the Shengyuanzhi group (t=3.011， P=0.008)， and the Miyuanzhi group (t=2.413， P=0.027)， and the Zhiyuanzhi group (t=1.941， P=0.068)， the codeine drug group (t=6.656， P=0.001)， the control group and the Shengyuanzhi group， the honeyyuanzhi group and the codeine drug group have statistically significant differences in antitussive effects(P<0.05); There was no statistically significant difference in the antitussive effect between the control group and Shengyuanzhi group， Miyuanzhi group， Zhiyuanzhi group and codeine drug group(P>0.05). Conclusion Through different processing methods， the efficacy of the traditional Chinese medicine Yuanzhi has a relatively large difference， and it can be used in clinical practice according to the actual conditions of patients., http://www.100md.com(王海花 孙靓)
[关键词] 中药;远志;炮制方法
[中图分类号] R283 [文献标识码] A [文章编号] 1674-0742(2020)09(c)-0178-03
[Abstract] Objective To analyze the effects of different processing methods on the efficacy of Chinese medicine Yuanzhi. Methods From January 2018 to June， the spontaneous activity counting method of 50 mice was selected to compare the sedative effects of different processing methods of Chinese medicine Yuanzhi; the methods of cough induced by ammonia and phenol red in the trachea were compared with different processing methods of the antitussive and phlegm effect of Chinese medicine Yuanzhi. Results Through the comparison of different processing methods， in terms of number of activities， the control group and the Shengyuanzhi group (t=12.796， P=0.001)， and the Miyuanzhi group (t=10.731， P=0.001)， and the Zhiyuanzhi group (t=13.348， P=0.001)， The sedative effects of the control group and the Shengyuanzhi group， the Miyuanzhi group， and the Zhiyuanzhi group，the difference was statistically significant(P<0.05); in terms of sleep time， the control group and the Shengyuanzhi group (t=2.681， P=0.015)， and the honeyyuanzhi group (t=2.688， P=0.015)， with the Zhiyuanzhi group (t=3.727， P=0.002)， with the sodium pentobarbital group (t=6.149， P=0.001)， the control group with the Shengyuanzhi group， the Miyuanzhi group， and the Zhiyuanzhi group The difference in hypnotic effect was statistically significant(P<0.05); in terms of the number of coughs the control group and the Shengyuanzhi group (t=3.011， P=0.008)， and the Miyuanzhi group (t=2.413， P=0.027)， and the Zhiyuanzhi group (t=1.941， P=0.068)， the codeine drug group (t=6.656， P=0.001)， the control group and the Shengyuanzhi group， the honeyyuanzhi group and the codeine drug group have statistically significant differences in antitussive effects(P<0.05); There was no statistically significant difference in the antitussive effect between the control group and Shengyuanzhi group， Miyuanzhi group， Zhiyuanzhi group and codeine drug group(P>0.05). Conclusion Through different processing methods， the efficacy of the traditional Chinese medicine Yuanzhi has a relatively large difference， and it can be used in clinical practice according to the actual conditions of patients., http://www.100md.com(王海花 孙靓)