封闭式负压引流联合前列地尔治疗糖尿病足溃疡的临床疗效分析(1)
[摘要] 目的 觀察封闭式负压引流联合前列地尔治疗糖尿病足溃疡的临床疗效。方法 随机选择2018年1月—2019年12月至该院进行糖尿病足溃疡治疗的患者100例进行临床研究。使用随机数字法将患者分为观察组和对照组，各50例，所有患者均给予控制血糖和前列地尔治疗。对照组患者创面给予常规换药，观察组患者给予封闭式负压引流。比较两组患者创面愈合时间、住院时间以及治疗前后疼痛评分和溃疡面积变化情况。比较两组患者临床疗效。 结果观察组患者创面愈合时间、住院时间均低于对照组，差异有统计学意义(t=3.637、4.000，P<0.05)，两组患者治疗前VAS评分和溃疡面积差异无统计学意义(P>0.05)，治疗后与该组治疗前相比均明显降低(P<0.05)，但观察组VAS评分和溃疡面积治疗后均低于对照组，差异有统计学意义(t=5.177、8.678，P<0.05);观察组治疗总有效率为96.00%，明显高于对照组84.00%，差异有统计学意义(χ2=4.000，P=0.046)。结论 封闭式负压引流联合前列地尔对于糖尿病足溃疡具有很好的临床疗效，明显缩短病程，减轻患者疼痛，缩小溃疡面积，提高患者生活质量。
[关键词] 封闭式负压引流;前列地尔;糖尿病足;溃疡
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2020)10(c)-0054-03
[Abstract] Objective To observe the clinical efficacy of closed negative pressure drainage combined with alprostadil in the treatment of diabetic foot ulcers. Methods Randomly select 100 patients who were treated for diabetic foot ulcer in the hospital from January 2018 to December 2019 for clinical research. The patients were divided into observation group and control group by random number method， each with 50 cases. All patients were given blood glucose control and alprostadil treatment. Patients in the control group were given routine dressing changes on their wounds， and patients in the observation group were given closed negative pressure drainage. The wound healing time， hospitalization time， pain score and ulcer area changes before and after treatment were compared between the two groups. Compare the clinical efficacy of the two groups of patients. Results The wound healing time and hospitalization time of the observation group were lower than those of the control group，and the difference was statistically significant(t=3.637，4.000，P<0.05). The VAS score and ulcer area of the two groups before treatment were not statistically significant difference(P>0.05). After treatment， compared with the group before treatment， both were significantly reduced(P<0.05)， but the VAS score and ulcer area of the observation group after treatment were lower than those of the control group， and the difference was statistically significant (t=5.177，8.678，P<0.05); the total effective rate of treatment in the observation group was 96.00%， which was significantly higher than that of the control group 84.00%，and the difference was statistically significant(χ2=4.000， P=0.046). Conclusion Closed negative pressure drainage and alprostadil have a good clinical effect on diabetic foot ulcers， which can shorten the course of the disease， reduce the pain of patients， reduce the area of ulcers， and improve the quality of life of patients., http://www.100md.com(吴继红 王海云 孔彩霞 齐秦 刘晓萍 韩晓丽 郝开花)
[关键词] 封闭式负压引流;前列地尔;糖尿病足;溃疡
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2020)10(c)-0054-03
[Abstract] Objective To observe the clinical efficacy of closed negative pressure drainage combined with alprostadil in the treatment of diabetic foot ulcers. Methods Randomly select 100 patients who were treated for diabetic foot ulcer in the hospital from January 2018 to December 2019 for clinical research. The patients were divided into observation group and control group by random number method， each with 50 cases. All patients were given blood glucose control and alprostadil treatment. Patients in the control group were given routine dressing changes on their wounds， and patients in the observation group were given closed negative pressure drainage. The wound healing time， hospitalization time， pain score and ulcer area changes before and after treatment were compared between the two groups. Compare the clinical efficacy of the two groups of patients. Results The wound healing time and hospitalization time of the observation group were lower than those of the control group，and the difference was statistically significant(t=3.637，4.000，P<0.05). The VAS score and ulcer area of the two groups before treatment were not statistically significant difference(P>0.05). After treatment， compared with the group before treatment， both were significantly reduced(P<0.05)， but the VAS score and ulcer area of the observation group after treatment were lower than those of the control group， and the difference was statistically significant (t=5.177，8.678，P<0.05); the total effective rate of treatment in the observation group was 96.00%， which was significantly higher than that of the control group 84.00%，and the difference was statistically significant(χ2=4.000， P=0.046). Conclusion Closed negative pressure drainage and alprostadil have a good clinical effect on diabetic foot ulcers， which can shorten the course of the disease， reduce the pain of patients， reduce the area of ulcers， and improve the quality of life of patients., http://www.100md.com(吴继红 王海云 孔彩霞 齐秦 刘晓萍 韩晓丽 郝开花)