[摘要] 目的： 观察单硝酸异山梨酯(ISMN)用于治疗老年单纯收缩期高血压(ISH)的疗效。方法： 选取ISH患者62例，随机分为对照组32例和治疗组30例。对照组应用非洛地平2.5 mg，每日晨服1次。治疗组于此基础上加用单硝酸异山梨酯20 mg，每日2次。分析两组患者治疗前、后血压和脉压(PP)变化。结果：治疗4周后治疗组收缩压(SBP)及脉压(PP)与治疗前比较有显著差异(P<0.01)；舒张压(DBP)下降不显著(P>0.05)；对照组治疗4周后SBP、DBP与治疗前比较下降显著(P<0.01)，PP减少不显著(P>0.05)。治疗后两组间SBP、DBP及PP比较有显著差异(P<0.05)。

    结论：单硝酸异山梨酯能降低ISH患者的SBP，而对DBP影响不大，可使PP减小，适合老年ISH患者的降压治疗。

    [关键词] 单纯收缩期高血压；老年 ；单硝酸异山梨酯

    [中图分类号] R541.3 [文献标识码]A [文章编号]1674-4721(2009)02(a)-012-02

    Clinical observation of senile patients with systolic hypertension treated by isosorbide mononitrate

    ZHANG Min

    (Hospital of Mudanjiang Normal college,Mudanjiang 157012,China)

    [Abstract] Objective：To study the efficacy of isosorbide mononitrate on senile patients with systolic hypertension. Methods：Sixty-two patients were randomly divided into control group (n=32)and treatment group (n=30).The control group was treated with felodipine 2.5 mg ......