宫颈鳞癌及癌前病变组织中ILK\PTEN的表达情况(1)
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2010年4月5日
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[摘要] 目的:探讨宫颈鳞癌及癌前病变组织中整合素连接激酶(ILK)、PTEN的表达情况。方法:采用免疫组化方法对50例宫颈鳞癌,28例CIN和12例正常宫颈组织进行ILK、PTEN检测,并结合临床资料进行统计分析。结果:宫颈鳞癌ILK阳性表达率明显高于正常组织和CIN 1、2级组织,ILK表达与肿瘤浸润、转移和临床分期密切相关;正常宫颈组织PTEN均呈阳性表达,而宫颈浸润癌组织PTEN表达率明显降低,但PTEN表达与肿瘤浸润、转移和临床分期无明显相关性。结论:宫颈鳞癌组织ILK呈高表达、PTEN呈低表达,可能在宫颈肿瘤浸润转移过程中起重要作用。
[关键词] 宫颈鳞癌;整合素连接激酶;免疫组织化学
[中图分类号] R737.33 [文献标识码]A [文章编号]1674-4721(2010)04(a)-05-03
The expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions
LIU Chunzai1, LI Chunling2, LI Shengshui3*, JIANG Ze4, LI Shuangbiao3, XU Hua3, ZHANG Fengmei3, LIU Yan3
(1.Nan Da Gang Hospital, Cangzhou061103, China; 2.Cangzhou Women & Children’s healthcare Hospital, Cangzhou061001, China; 3.Cangzhou Hospital for Integrated Chinese and Western Medicine, Cangzhou061001, China; 4.Cangzhou Central Hospital, Cangzhou061001, China)
[Abstract] Objective: To study the expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions. Methods:50 cases of cervical squamous carcinoma, 28 cases of cervical intraepithelial neoplasia( CIN) and 12 cases of normal cervical tissues ample were stained for ILK,PTEN by immunohistochemistry method. Results: ILK positive expression rate in cervical squamous carcinoma was significantly higher than that in normal cervical tissue and CIN I. The positive expression rate of PTEN in normal cervical tissue was 100.0%, but it was remarkably decreased in cervical squamous carcinoma. Our analysis indicated that no significant relationship was found between the state of PTEN expression and invasion,metastasis and the clinical stage of the tumor. Conclusion: The higher expression of ILK and the lower expression of PTEN in cervical squamous carcinoma may play an important role in angiogenesis of cervical squamous carcinoma.
[Key words] Cervical squamous carcinoma; ILK; Immunohistochemistry
宫颈鳞状细胞癌(cervical squamous cell carcinoma, SCC)是世界上发病率仅次于乳腺癌的女性第二常见肿瘤,目前仍是女性生殖系统发病率最高的恶性肿瘤,且近年发病率趋于年轻化,严重危害女性生理、心理健康[1]。近年来,随着分子生物学的发展,人们开始关注SCC发生、发展的分子生物学机制 ......
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