初诊多发性骨髓瘤患者血钙异常临床分析研究(1)
http://www.100md.com
2010年4月5日
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[摘要] 目的:为了了解初诊多发性骨髓瘤患者血钙异常及其相关影响因素,血钙与多发性骨髓瘤患者肿瘤负荷水平相关性研究。方法:回顾性分析105例多发性骨髓瘤(MM)的临床资料。结果:低钙组与正常血钙组比较,差异有统计学意义的指标分别为清蛋白、血红蛋白、血肌酐(P<0.05),高钙组与正常血钙组比较,差异有统计学意义的指标为血磷(P<0.05)、血肌酐(P<0.01)。血钙等对β2-MG分别做简单相关分析及多重线性回归分析,β2-MG与LDH、M蛋白量、Scr、骨骼损害积分相关,但与血钙水平并不相关。结论:血钙异常是多发骨髓瘤患者重要的临床表现,但其与病情严重程度无关。
[关键词] 血钙;多发性骨髓瘤(MM);β2微球蛋白(β2-MG);分期
[中图分类号] R551.3 [文献标识码]A [文章编号]1674-4721(2010)04(a)-07-02
The clinical analysis of serum calcium of newly diagnosed multiple myeloma
YANG Xinyu1,FANG Yibing1*,XIAO Peiling1,DUAN Huaxin1,CHEN Xi′an2
(1.The First Affiliated Hospital of Hunan Normal University,Changsha 410005, China;2.The Second Xiangya Hospital of Central South University,Changsha 410000, China)
[Abstract] Objective: In order to study abnormal serum calcium and its related factors in new diagnosed patients with multiple myeloma,serum calcium correlation with tumor burden of multiple myeloma. Methods: Retrospective analysis the clinical data of 105 cases of multiple myeloma. Results: The difference between the low calcium group and the normal group had statistically significant,was albumin,hemoglobin,serum creatinine(P<0.05),the difference between the high calcium group and the normal group had statistically significant,was phosphorus(P<0.05),serum creatinine(P<0.01). Simple correlation analysis and multiple linear regression analysis for calcium and the other indicators to β2-MG,β2-MG with LDH,M Protein content,Scr,bone damage points are correlated,but the serum calcium was not correlated to β2-MG.Conclusion:Abnormal serum calcium is an important clinical symptoms of multiple myeloma,but it′s not correlated with severity of paitents.
[Key words] Serum calcium; Multiple myeloma (MM); β2-microglobulin(β2-MG); Stages
多发性骨髓瘤(MM)是浆细胞恶性单克隆增殖性疾病,目前多发性骨髓瘤(MM)仍被视为不可治愈的疾病,而且MM的发病率有增高趋势,高钙血症是多发性骨髓瘤(MM)的重要临床特征。笔者对初诊收治的105例多发性骨髓瘤(MM)患者的血钙等检查特点进行回顾性总结。以期为临床诊疗提供依据。
1 资料与方法
1.1 一般资料
2006年2月～2009年2月本院和中南大学湘雅二医院收治的105例MM患者,其中,男性70例(66 ......
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