间歇性高容量血液滤过治疗严重脓毒症的临床观察(1)
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[摘要] 目的:探讨间歇性高容量血液滤过(PHVHF)治疗严重脓毒症的疗效及应用。方法:将25例严重脓毒症患者随机分为PHVHF组13例、对照组12例。PHVHF组给予常规治疗,同时给予PHVHF治疗;对照组只给予常规治疗。观察治疗前、后急性生理学与慢性健康状况(APACHE)Ⅱ评分;心率(HR)、平均动脉压(MAP)、中心静脉压(CVP)等血流动力学指标;血液生化指标(BUN、Cr、K+、Na+、Cl-);氧合指数(PaO2/FiO2);机械通气时间、ICU内治疗时间,28 d病死率。结果:PHVHF组治疗后HR、BUN、Cr、K+、 PaO2/FiO2、APACHEⅡ评分均较治疗前显著改善(P<0.05),其中,治疗后BUN、Cr、PaO2/FiO2、APACHEⅡ评分两组比较, 差异有统计学意义(P<0.05); PHVHF组机械通气时间、ICU内治疗时间短,28 d病死率低,其中,ICU内治疗时间,两组患者比较,差异有统计学意义(P<0.05)。结论:PHVHF能稳定血流动力学,并通过对内环境调节、改善氧合等,对多个器官起到支持作用,可减轻严重脓毒症的病情及改善预后,且操作简便,是严重脓毒症的有效治疗手段。
[关键词] 脓毒症;间歇性高容量血液滤过;血流动力学
[中图分类号] R63 [文献标识码]A [文章编号]1674-4721(2010)04(c)-033-03
Clinical observation on intermittent high volume hemofiltration treatment of severe sepsis
HUANG Tao
(Department of ICU,the Red Cross Hospital of Shenyang, Shenyang 110013, China)
[Abstract] Objective: To investigate the treatment effectiveness and application of pulse high volume hemoflitration (PHVHF) in patients with severe sepsis. Methods: The 25 patients with severe sepsis were randomly divided into PHVHF group 13 cases and control group 12 cases.PHVHF group was given conventional treatment, while giving PHVHF treatment; the control group received conventional therapy only. Observed before and after treatment of acute physiology and chronic health conditions(APACHE)Ⅱ score; heart rate(HR), mean arterial pressure(MAP), central venous pressure (CVP) and other hemodynamic parameters;blood biochemical parameters (BUN,Cr,K+,Na+,Cl-);oxygenation index(PaO2/FiO2);mechanical ventilation time,ICU treatment time period,28 days mortality. Results: After treatment,PHVHF group's HR,BUN,Cr, K+,PaO2/FiO2, APACHE Ⅱ score was significantly improved than that before treatment(P<0.05),which,after treatment,BUN,Cr,PaO2/FiO2, APACHE Ⅱ score between the two groups,the difference statistically significant(P<0.05);PHVHF group of mechanical ventilation,ICU treatment within a short time,28 days mortality rate was low,which ICU treatment time between the two groups of patients,the difference was statistically significant(P<0 ......
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