塞来昔布联合奥氮平治疗难治性抑郁症的随机双盲对照(1)
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[摘要] 目的:探讨塞来昔布联合奥氮平治疗难治性抑郁症的临床效果。方法:采用双盲对照研究,将66例诊断为难治性抑郁症的患者随机分为观察组和对照组,每组各33例,观察组采用塞来昔布联合奥氮平治疗,对照组采用塞来昔布治疗,两组在治疗后1、2、4、8周末采用汉密顿抑郁量表(HAMD),副反应量表(TESS)评定两组的药物副作用。结果:观察组的总有效率为87.88%,对照组为60.61%,两组差异有统计学意义(P<0.05),药物副作用两组间差异无统计学意义(P>0.05)。结论:塞来昔布联合奥氮平治疗难治性抑郁症起效快、安全性高,并能迅速改善睡眠障碍和焦虑。
[关键词] 塞来昔布;奥氮平;抑郁症
[中图分类号] R971+.43 [文献标识码]A [文章编号]1674-4721(2010)05(b)-022-03
Celecoxib combined with olanzapine in the treatment of refractory depression by randomizing double-blind controlled
CAI Yuanfan
(WU Zhongpei Memorial Hospital of Shunde District, Foshan City, Guangdong Province, Foshan 528300, China)
[Abstract] Objective: To study the clinical effects of celecoxib combined with olanzapine in the treatment of refractory depression. Methods: Double-blind controlled study were used,66 cases were diagnosed as treatment-resistant depression, and were randomly divided into the observation group and the control group, 33 cases for each group,the observation group were treated with celecoxib combined with olanzapine, the control group were treated with celecoxib. 1,2,4,6,8 weeks later,two groups were used the hamilton depression rating Scale (HAMD), emergent symptom scale (TESS) assessment of drug side-effects after treatment. Results: The total effective rate of the observation group was 87.88%, and the control group was 60.61%,difference between the two groups had statistical significance(P<0.05), there was no significant difference of the drug side effects between the two groups (P>0.05). Conclusion: Celecoxib combined with olanzapine in the treatment of refractory depression is fast onset, high security, and can quickly improve the sleep disorder and anxiety.
[Key words] Celecoxib;Olanzapine;Depression
抑郁症是常见的精神障碍性疾病,在我国发病率达0.2%~0.3%,大部分药物起效慢、疗效欠佳。抑郁症又称忧郁症,是以情绪低落为主要特征的一类心理疾病,其临床表现为:轻型患者外表如常,内心有痛苦体验;病情稍重的人可表现为情绪低落、愁眉苦脸、唉声叹气、自卑等,有些患者常常伴有神经功能症症状,如:注意力不集中、记忆力减退、反应迟缓、失眠多梦等症状。由于患者思维逻辑基本正常,实施自杀的成功率也较高。自杀是抑郁症最危险的症状之一。据研究,抑郁症患者的自杀率比一般人群高20倍。近年来临床研究发现,联合用药治疗抑郁症可取得肯定疗效[1]。抗感染制剂塞来昔布是一种环氧合酶-2(cyclo-oxygenase-2,COX-2)抑制剂,合并抗精神药可治疗精神分裂症[2~4]。笔者采用塞来昔布联合奥氮平治疗难治性抑郁症66例取得满意疗效,现报道如下:
1 资料与方法 ......
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