匹维溴胺联合氟哌噻吨美利曲辛及谷维素治疗肠易激综合征疗效探讨(1)
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[摘要] 目的：探讨匹维溴胺联合氟哌噻吨美利曲辛及谷维素治疗肠易激综合征(IBS)的临床疗效。方法：选择54例IBS患者，随机分为治疗组、对照组两组，每组各27例。对照组采用匹维溴胺治疗，50 mg/次，3次/d；治疗组在此基础上服用氟哌噻吨美利曲辛，1片/d，早晨口服，以及谷维素，20 mg/次，3次/d，疗程均为1个月。观察两组治疗前后的临床疗效、症状、体征。结果：治疗组显效率为81.48%，对照组显效率为55.56%，治疗组与对照组比较，差异有统计学意义(P<0.05)。治疗组对缓解腹痛、腹泻、便秘等症状优于对照组。结论：匹维溴胺联合氟哌噻吨美利曲辛及谷维素可有效改善IBS患者的临床症状、提高疗效。
[关键词] 肠易激综合征；匹维溴胺；氟哌噻吨美利曲辛；谷维素
[中图分类号] R574.4 [文献标识码]A[文章编号]1674-4721(2011)04(a)-035-02
Therapeutic evaluation of pinaverium bromide combined with flupentixol melitracen and oryzanolum in the treatment of irritable bowel syndrome
CHEN Mingrui
Mianyang Youxian Fujiang Community Health Service Center, Sichuan Province, Mianyang 621000, China
[Abstract] Objective: To study the therapeutic effects of pinaverium bromide combined with deanxit and oryzanolum in the treatment of irritable bowel syndrome (IBS). Methods: 54 patients with IBS were randomly divided into two groups: the treatment group and the control group (n=27). The patients in the control group were treated with pinaverium bromide 50 mg three times daily, and those in the treatment group were given deanxit one time daily in early morningand oryzanolum 20 mg three times dailybased on the above treatment. The period of treated was 1 month. The clinical efficacy, symptoms and signs were observed before and after the treatment. Results: The significantly effective rate was 81.48% in the treatment group and 55.56% in the control group, there was significantly difference between the two groups (P<0.05). The abdominal pain, diarrhea, constipation and other symptoms were better relieved in the treatment group than in the control group. Conclusion: The pinaverium bromide combined with pinaverium bromide and oryzanolum can effectively improve the clinical symptoms of patients with IBS and increase the therapeutic effects.
[Key words] Irritable bowel syndrome; Pinaverium bromide; Deanxit; Oryzanolum
肠易激综合征(irritable bowel syndrome，IBS)是一种以腹痛或腹部不适伴排便习惯改变为特征的功能性肠病，经检查排除可引起这些症状的器质性疾病，是临床上最常见的一种胃肠道功能紊乱性疾患。研究证明，不仅在IBS方面花费的医疗资源相当巨大，而且还程度不一地影响患者的生命质量，也是工作缺勤的原因之一[1]。由于该病病程长、易反复、患病率高、治疗困难等而引起人们的广泛重视 ......
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