YKL-40与肿瘤相关巨噬细胞在非小细胞肺癌中的表达及预后分析(3)
在本次研究中笔者发现NSCLC患者YKL-40的水平与TAM的表达具有同步性，YKL-40和TAM之间存在正相关。因此，NSCLC患者体内的YKL-40主要来源可能是TAM。从这个意义来推测，YKL-40有可能是执行TAM生物学作用的下游蛋白之一。笔者发现，在合并淋巴结转移、浸润较深的肺癌患者中YKL-40表达增高，Ⅲ期YKL-40阳性率高于Ⅰ期和Ⅱ期患者；随访中发现，部分 YKL-40高表达的患者，术后早期复发的情况较多见；提示YKL-40增高可能是不良的预后因素。病灶局部TAM的水平术前无法测定，术后对于患者体内TAM表达状况仍然无法直接获得，但是术前和术后YKL-40的水平可以通过ELIAS进行测定。对于YKL-40水平明显增高的患者，笔者可以看作为体内TAM活动的指标，作为一种高危因素应注意加强术后的辅助治疗和动态监测，从而对病情作更好的预测，为肺癌的管理提供有力的信息。但本组患者的数量还偏少，临床资料还需要进一步扩大；还需要后续的研究来深化结论。
[参考文献]
, 百拇医药
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, 百拇医药
[3]林风武,戚良晨,程苏影,等.非小细胞肺癌中的PCNA、P53、rasP21的表达[J].中国实验诊断学,2005,9(5):707-708.
[4]詹庆华,陈维荣.肿瘤相关巨噬细胞促进微淋巴管生成的研究进展[J].国际病理科学与临床杂志,2009,29(2):165-169.
[5]李彬,朱迅.肿瘤相关巨噬细胞研究进展[J].国际免疫学杂志,2010,33(3):189-192.
[6]章必成,王俊,陈正堂.肿瘤相关巨噬细胞的研究进展[J].临床肿瘤杂志,2007,3(12):228-230.
[7]Qian B,Deng Y,Im JH,et al.A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation,Establishment and Growth[J].PLoS ONE,2009,10,4(8):e6562.
, 百拇医药
[8]Gocheva V,Wang HW,Gadea BB,et al.IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion[J].Genes & Dev,2010,1(24):241-255.
[9]Rehli M,Niller HH,Ammon C,et al.Transcriptional regulation of CHI3L1,a marker gene of late stages of macrophage differentiation[J].Biol Chem,2003,278(45):44058-44067.
[10]Johansen JS,Williamson MK,Rice JS, et al.Identification of proteins secreted by human osteoblastic cells in culture[J].J Bone Miner Res,1992,7(5):501-512.
, 百拇医药
[11]Junker N,Johansen JS,Andersen CB,et al.Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer[J].Lung Cancer,2005,48(2):223-231.
[12]Nishikawa KC,Millis AJ.Gp38k(CHI3L1) is a novel adhesion and migration factor for vascular cells[J].Exp Cell Res,2003,287(1):79-87.
[13]程明刚,郝艳华,姚吉龙.YKL-40在恶性肿瘤中的研究及应用[J].国际检验医学,2009,9(29):803-805.
(收稿日期：2011-03-10), 百拇医药(周芳 胡秀峰 杨柳)
[参考文献]
, 百拇医药
[1]Postmus,Pieter E,Brambilla,et al.The IASLC Lung Cancer Staging Project:Proposals for Revision of the M Descriptors in the Forthcoming (Seventh) Edition of the TNM Classification of Lung Cancer[J].Journal of Thoracic Oncology,2007,2(8):686-693.
[2]Chen H,Wang LD,Guo M,et al.Alterations of p53 and PCNA in cancer and adjacent tissues from concurrent carcinomas of the esophagus and gastric cardia in the same patient in Linzhou, a high incidence area for esophageal cancer in northern China[J].World J Gastroenterol,2003,9(1):16-21.
, 百拇医药
[3]林风武,戚良晨,程苏影,等.非小细胞肺癌中的PCNA、P53、rasP21的表达[J].中国实验诊断学,2005,9(5):707-708.
[4]詹庆华,陈维荣.肿瘤相关巨噬细胞促进微淋巴管生成的研究进展[J].国际病理科学与临床杂志,2009,29(2):165-169.
[5]李彬,朱迅.肿瘤相关巨噬细胞研究进展[J].国际免疫学杂志,2010,33(3):189-192.
[6]章必成,王俊,陈正堂.肿瘤相关巨噬细胞的研究进展[J].临床肿瘤杂志,2007,3(12):228-230.
[7]Qian B,Deng Y,Im JH,et al.A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation,Establishment and Growth[J].PLoS ONE,2009,10,4(8):e6562.
, 百拇医药
[8]Gocheva V,Wang HW,Gadea BB,et al.IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion[J].Genes & Dev,2010,1(24):241-255.
[9]Rehli M,Niller HH,Ammon C,et al.Transcriptional regulation of CHI3L1,a marker gene of late stages of macrophage differentiation[J].Biol Chem,2003,278(45):44058-44067.
[10]Johansen JS,Williamson MK,Rice JS, et al.Identification of proteins secreted by human osteoblastic cells in culture[J].J Bone Miner Res,1992,7(5):501-512.
, 百拇医药
[11]Junker N,Johansen JS,Andersen CB,et al.Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer[J].Lung Cancer,2005,48(2):223-231.
[12]Nishikawa KC,Millis AJ.Gp38k(CHI3L1) is a novel adhesion and migration factor for vascular cells[J].Exp Cell Res,2003,287(1):79-87.
[13]程明刚,郝艳华,姚吉龙.YKL-40在恶性肿瘤中的研究及应用[J].国际检验医学,2009,9(29):803-805.
(收稿日期：2011-03-10), 百拇医药(周芳 胡秀峰 杨柳)