促红细胞生成素防治早产儿贫血的临床观察(1)
 |
| 第1页 |
参见附件(1938KB，2页)。
[摘要] 目的：观察重组人促红细胞生成素(rhEPO)防治早产儿贫血的临床效果。方法：将96例早产儿(胎龄30～35周)随机分为观察组和对照组各48例。对照组给予常规治疗；观察组除常规治疗外，从出生第7天开始给予rhEPO 250 IU/(kg·次)，隔日1次，每周3次，皮下注射，共用药4周，必要时输血。分别检测用药前、用药后4周血常规红细胞(RBC)、血红蛋白(Hb)、红细胞压积(HCT)、网织红细胞(Ret)等指标的变化。结果：两组血常规各项指标进行对比分析，观察组与对照组比较，差异有统计学意义(P<0.05)。观察组输血发生率显著低于对照组(P<0.05)(观察组为16.7%，对照组为39.6%)。结论：促红细胞生成素防治早产儿贫血效果明显，可减少输血次数。
[关键词] 促红细胞生成素；早产儿；贫血；临床观察
[中图分类号] R722 [文献标识码]A[文章编号]1674-4721(2011)06(a)-028-02
Erythropoietin in anemia prevention and control clinical observation of premature children
HOU Shuping
Department of Pediatrics, Puyang City Oil Field General Hospital, Henan Province, Puyang 457001, China
[Abstract] Objective: To observe the recombinant human erythropoietin (rhEPO) control the clinical effects of anemia in premature children. Methods: 96 preterm children (gestational age 30 to 35 weeks) were randomly divided into two groups and the control group of 48 cases. The control group received conventional therapy; observation group in addition to conventional treatment, the 7th day from birth to give rhEPO 250 IU/(kg·time), every other day for 1, 3 times a week, administered subcutaneously 4 weeks, if necessary, blood transfusions. Detected before treatment, 4 weeks after treatment blood red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), reticulocytes (Ret) and other indicators of change. Results: Both groups were analyzed blood indicators was observed compared with the control group, the difference was statistically significant (P<0.05). Transfusion observation group were significantly lower than the control group (P<0.05) (16.7% in the observation group and control group 39.6%). Conclusion: Control of erythropoietin effect is anemia in preterm children, can reduce the number of transfusions.
[Key words] Erythropoietin; Premature child; Anemia; Clinical observation
早产儿贫血是临床常见疾病，贫血对早产儿的智力、体格发育及免疫功能等均有一定影响。笔者应用重组人促红细胞生成素(rhEPO)防治早产儿贫血，取得满意疗效，现报道如下：
1 资料与方法
1.1 一般资料
选取2008年1月～2010年12月在新生儿病房住院的早产儿共96例。入选标准：胎龄30～35周，血常规检查血红蛋白(Hb)在160～190 g/L。将其随机分为观察组和对照组，每组各48例。所有患儿均排除严重感染、持续出血、机械通气、长期禁食、先天畸形及血液系统疾病等 ......
您现在查看是摘要介绍页，详见PDF附件(1938KB，2页)。