孕16~28周胎儿脐血β-地中海贫血基因及其血红蛋白电泳\红细胞参数变异分析(1)
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[摘要] 目的：探讨红细胞参数和毛细管血红蛋白电泳及β-地中海贫血基因检测在产前诊断β-地中海贫血中的互补作用。方法：210 例孕16～28周胎儿脐血标本根据β-地中海贫血基因型测定结果分为4 组，对4 组血常规结果中的平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、平均红细胞血红蛋白浓度(MCHC)及血红蛋白A(HbA%)、等多参数进行统计分析。结果：对照组MCV、MCH、MCHC与其他各组结果对比差异无统计学意义(P>0.05)；但HbA(%)在其他组间的结果均低于对照组，差异有统计学意义(P<0.05)。结论：孕16～28周胎儿脐血MCV、MCH及MCHC检测对β-地中海贫血的产前诊断价值不大，而脐血毛细管血红蛋白电泳及β-地中海贫血基因联合检测则有很好的互补作用。
[关键词] β-地中海贫血基因；产前诊断；脐血；血常规；毛细管血红蛋白电泳
[中图分类号] R55 [文献标识码] C[文章编号] 1674-4721(2011)06(a)-086-03
16-28 weeks fetal gestational umbilical cord blood beta Mediterranean anemia genes and their hemoglobin electrophoresis, RBC parameter variation analysis
ZHANG Lijun1, LIU Aiqin1, ZHONG Liruo2
1.Department of Laboratory, Second Clinical College of Jinan University Shenzhen City People′s Hospital, Guangdong Province, Shenzhen 518020, China; 2.Department of Obstetrics, Second Clinical College of Jinan University Shenzhen City People′s Hospital, Guangdong Province, Shenzhen 518020, China
[Abstract] Objective: To study the red blood cell parameters and capillary electrophoresis and β-hemoglobin gene to detect anemia in the prenatal diagnosis of β thalassemia in the complementary role. Methods: 210 pregnant and 16 to 28 weeks of fetal cord blood samples according to determination of β-thalassemia genotypes were divided into 4 groups, 4 groups of blood results mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and hemoglobin A (HbA%), and other parameters were analyzed. Results: In Group MCV, MCH, MCHC compared with results of other groups no significant difference (P>0.05); but HbA (%) results in the other groups were lower than the control group, the difference was statistically significant (P<0.05). Conclusion: 16-28 weeks pregnant fetal cord blood MCV, MCH and MCHC detection of β-thalassemia prenatal diagnosis of little value, and cord blood capillary electrophoresis and β-hemoglobin gene and detection of anemia is to have a good complementary ......
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