血清CA125\CA199\CEA及VEGF联合检测在卵巢癌诊断中的意义研究(1)
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[摘要] 目的：探讨血清CA125、CA199、CEA及VEGF联合检测在卵巢癌诊断中的意义。方法：选取2008年12月~2010年12月于本院进行治疗的32例卵巢癌患者为观察组，选取同期的32例卵巢良性肿瘤患者为对照组，后将两组患者的血清CA125、CA199、CEA及VEGF水平进行统计检测及比较。结果：观察组的血清CA125、CA199、CEA及VEGF阳性率及含量均显著高于对照组，且卵巢癌患者中随分期增加，水平和阳性率呈增高趋势，P<0.05或P<0.01，差异有统计学意义。结论：血清CA125、CA199、CEA及VEGF联合检测在卵巢癌诊断中有重要的作用，可提高检出率及了解病情严重程度。
[关键词] 血清因子；联合检测；卵巢癌；诊断
[中图分类号] R737.31 [文献标识码]A[文章编号]1674-4721(2011)06(b)-035-02
The study on the significance of combined detection of serum CA125，CA199，CEA and VEGF in diagnosis of ovarian cancer
GONG Chunfang
Liangshan Town Central Hospital of Yushui Area in Xinyu City, Jiangxi Province, Xinyu338000, China
[Abstract] Objective: To study the significance of combined detection of serum CA125, CA199, CEA and VEGF in diagnosis of ovarian cancer. Methods: 32 patients with ovarian cancer in our hospital from December 2008 to December 2010 were selected as observation group, and 32 patients with benign ovarian tumor at the same time were selected as control group, then the serum CA125, CA199, CEA and VEGF of two groups were detected and compared. Results: The positive rate and content of serum CA125, CA199, CEA and VEGF of observation group were all higher than those of control group, and the positive rate and content levels increased withstage increasing, P<0.05 or P<0.01, there were significant differences. Conclusion：The combined detection of serum CA125, CA199, CEA and VEGF in diagnosis of ovarian cancer plays an important role, and it can improve the detection rate and investigate disease severity.
[Key words] Serum factors; Combined detection; Ovarian cancer; Diagnosis
卵巢恶性肿瘤早期无典型症状及体征，多数患者未能引起注意及重视，延误最佳治疗期，其致死率占各种妇科肿瘤的首位，对妇女生命造成严重威胁[1]。因此早期的诊断及治疗对于改善其预后作用重大。本文中笔者就血清CA125、CA199、CEA及VEGF联合检测在卵巢癌诊断中的意义进行研究，现将结果总结报道如下：
1资料与方法
1.1一般资料
选取2008年12月~2010年12月于本院进行治疗的32例卵巢癌患者为观察组，选取同期的32例卵巢良性肿瘤患者为对照组。观察组的32例卵巢癌患者中，年龄20～75岁，平均(53.9±4.2)岁，分期：Ⅰ期7例，Ⅱ期10例，Ⅲ期9例，Ⅳ期6例。对照组的32例卵巢良性肿瘤患者中，年龄21～76岁，平均(54.3±4.4)岁，其中畸胎瘤21例，囊腺瘤11例。两组患者年龄等基本资料差异无统计学意义，P>0.05，具有可比性。
1.2方法
将两组患者的血清CA125、CA199、CEA及VEGF水平进行统计检测及比较。取患者晨起空腹血5 ml送检，血清CA125采用人卵巢癌抗原(CA125)ELISA试剂盒进行检测，血清CA199采用人糖连抗原199(CA199)ELISA试剂盒进行检测 ......
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