胃肠道间质瘤诊断与治疗的临床研究(1)
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[摘要] 目的：分析胃肠道间质瘤临床常用的诊断与治疗方法，并对其方法的有效性、安全性进行研究。方法：选择2005年1月～2010年1月在本院进行了手术治疗的胃肠道间质瘤患者共65例作为治疗组，随机选择同一时段86例胃、结直肠癌患者做为对照组，比较分析治疗组与对照组的CT、消化道造影、内镜+活检资料的临床价值。将该组胃肠道间质瘤患者按照手术后是否服用甲磺酸伊马替尼分为两组，治疗组：手术+甲磺酸伊马替尼，对照组：手术。分析二者在疗效上的差异。结果：CT、消化道造影、内镜+活检等临床资料显示出能够帮助诊断的显著性的差异。是否服用甲磺酸伊马替尼在复发、转移、生存时间等方面具有显著性差异。结论：临床资料不能确诊胃肠道间质瘤，但能够提供相当准确的临床诊断；GIST术后复发率很高，甲磺酸伊马替尼对防止转移、复发、延长生存时间有良好的疗效。
[关键词] 胃肠道间质瘤；甲磺酸伊马替尼；诊断；治疗
[中图分类号] R735[文献标识码]B [文章编号]1674-4721(2011)06(b)-136-03
Clinical research of gastro-intestinal tract mesenchymoma diagnosis and treatment
LI Baifeng, WANG Jing, QI Jiang, TAN Xiangyun, LI Lin
Zhuzhou No.1 Hospital of Hunan Province, Zhuzhou 412000, China
[Abstract] Objective: To analyze the clinical gastrointestinal stromal tumors commonly used in diagnosis and treatment, and its validity and safety research. Methods: Since January 2005 to January 2010 underwent surgery in our hospital treatment for patients with gastrointestinal stromal tumor as a treatment group were 65 patients, randomly selected 65 cases during the same period of gastric, colorectal cancer patients as controls group, comparative analyzed of the treatment group and control group CT, gastrointestinal imaging, endoscopy + biopsy in the clinical value of the information. The group of cases of gastrointestinal stromal tumors after surgery were taken in accordance with imatinib mesylate divided into two treatment groups: surgery plus imatinib mesylate, the control group: surgery. Analyzed of the difference in efficacy between the two groups. Results: CT, gastrointestinal imaging, endoscopy + biopsy and other clinical information that can help diagnose the significance of differences. Did taking imatinib mesylate in the recurrence, metastasis, survival time, and so had significant differences. Conclusion: The clinical data can not be diagnosed with gastrointestinal stromal tumors, but can provide quite accurate clinical diagnosis; GIST recurrence rate is high, imatinib mesylate to prevent metastasis and recurrence, prolong survival time on good effect.
[Key words] Gastrointestinal stromal tumor; Imatinib mesylate; Diagnosis; Treatment
胃肠道间质瘤(gastrointestinal stromal tumors，GIST)是一组独立起源于胃肠道间质干细胞的肿瘤，属于消化道间叶性肿瘤。消化道间叶肿瘤占的比例很少，但在消化道间叶性肿瘤中，GIST占有重要的位置[1]。近几年来，GIST的诊断治疗一直是临床医学研究的热点内容。本文从临床诊断与治疗角度出发，结合文献探索GIST 的诊断和治疗等方面的新进展 ......
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