COPD患者血清IL-8\hs-CRP水平变化的临床研究
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[摘要] 目的：探讨COPD患者治疗前、后血清白介素-8(IL-8)与高敏C-反应蛋白(hs-CRP)的变化。方法：选择COPD患者47例，采用酶联免疫法测定IL-8、hs-CRP，以周期体检健康者47例作为对照。结果：COPD患者治疗前IL-8水平为(1.91±1.69) ng/L，治疗后为(1.29±1.52) ng/L，治疗后明显降低(P<0.01)；hs-CRP治疗前为(56.09±32.11) mg/L，治疗后为(7.29±2.05) mg/L，治疗后明显降低(P<0.01)。结论：IL-8、hs-CRP参与了COPD患者气道炎症反应，可作为判断COPD患者病变严重程度和观察治疗效果的指标。
[关键词] 慢性阻塞性肺病；血清白介素-8；高敏C反应蛋白；临床研究
[中图分类号] R563 [文献标识码]A[文章编号]1674-4721(2011)07(a)-028-03
Clinical study of serum IL-8, hs-CRP levels change in patients with COPD
WU Ronghua1, XU Jianhui1, HUANG Ping2, CHEN Jiaxin1, LI Yongqiang1, LIANG Dongwei2, LIANG Weiquan1
1.Department of Respiratory, the Second People′s Hospital of Nanhai District of Foshan City, Guangdong Province, Foshan 528251, China; 2.Department of Laboratory, the Second People′s Hospital of Nanhai District of Foshan City, Guangdong Province, Foshan 528251, China
[Abstract] Objective: To discuss the patients with COPD before and after treatment of serum interleukin-8 (IL-8) and high sensitivity-C reactive protein (hs-CRP) changes. Methods: Selected 47 cases of COPD patients, to be used enzyme-linked immunosorbent assay IL-8, hs-CRP, the healthy cycle of 47 cases for control group. Results: COPD patients′ IL-8 levels was (1.91±1.69) ng/L before treatment, after treatment was (1.29±1.52) ng/L, significantly decreased after treatment (P<0.01); hs-CRP before treatment was (56.09±32.11) mg/L, after treatment was (7.29±2.05) mg/L, significantly decreased after treatment (P<0.01). Conclusion: IL-8, hs-CRP involved in airway inflammation in patients with COPD and can be used to judge severity of COPD patients and observation for treatment outcome.
[Key words] COPD; Serum interleukin-8; High-sensitivity C-reactive protein; Clinical study
慢性阻塞性肺病(chronic obstructive pulmona-ry disease，COPD)是一种具有气流受限特征的肺部疾病，气流受限不完全可逆，呈进行性发展。虽然确切的病因还不十分清楚，但认为与肺部对有害气体或有害性颗粒的异常炎症反应有关[1]。IL-8是构成COPD气道炎性反应的复杂的炎症细胞、细胞因子网络的重要组成成份，能相互促进，加速局部炎性反应的发生发展，最终导致气道结构的重塑和气流阻塞的形成，在COPD发病中起着十分重要的作用。高敏C-反应蛋白(High-sensitivity C-reactive protein，hs-CRP)是一种急性时相蛋白，是反映机体感染性炎症的敏感指标，其真实性可靠，临床常常通过动态检测该物质来判断疾病的转归。hs-CRP为急性时相关的炎症的敏感指标，但它作为转录后调节产物的一部分，可能不能完全反映体内炎症的真实情况[2]。笔者检测了COPD患者血清白介素-8与高敏C-反应蛋白治疗前后的变化 ......
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