环磷酰胺联合免疫球蛋白治疗小儿病毒性心肌炎90例疗效观察(1)
 |
| 第1页 |
参见附件。
[摘要] 目的 探讨环磷酰胺联合免疫球蛋白治疗小儿病毒性心肌炎的临床疗效。 方法 对90例患儿采用环磷酰胺联合免疫球蛋白治疗，与另外95例单独使用环磷酰胺治疗的患儿进行对照。 结果 环磷酰胺组患者显效25例，有效20例，无效48例，显效率为26.9%，总有效率为48.4%；联合治疗组患者显效35例，有效38例，无效17例，显效率为38.9%，总有效率为81.1%。两组患者治疗显效率及总有效率差异均有统计学意义(P < 0.05)，联合治疗组疗效优于环磷酰胺组。 结论 环磷酰胺联合免疫球蛋白是治疗小儿病毒性心肌炎的一种有效方法。
[关键词] 环磷酰胺；免疫球蛋白；小儿；病毒性心肌炎
[中图分类号] R725.4 [文献标识码] A [文章编号] 1674-4721(2012)02(a)-0076-02
An observation on the clinical effect of a combine treament in Cyclophosphamide and immunoglobulin 90 pediatric cases with viral myocarditis
WU Jun
Pediatrics of Cili People's Hospital in Zhangjiajie City in Hunan Province, Cili 427200, China
[Abstract] Objective To explore the clinical effect of the treament which combines Cyclophosphamide and Immunoglobulin to Viral Myocarditis (VM) in child patient. Methods Ninety patients of treament were given combined treament of Cyclophosphamide and immunoglobulin, and compared with 95 patients of the contrast group in which Cyclophosphamide alone was used. Results Among the 93 patients in contrast group, there were 25 patients whose treament found significantly effective, 20 cases effective and 48 cases with no any significance. The significantly effective rate was 26.9% and total effective rate was 48.4%; in the control group, 35 cases of significant effect, 38 cases of effect and 17 cases of no significance. Significantly effective rate was 38.9% and total effective rate was 81.1%. There existed a statistic significance between two groups (P < 0.05). Clinical effect in control group excelled the contrast one. Conclusion The combined treatment of cyclophosphamide and immunoglobulin is a feasible method in tackling VM in child patients.
[Key words] Cyclophosphamide; Immunoglobulin; Child patient; Viral Myocarditis
病毒性心肌炎(viral myocarditis，VM)是儿科心血管常见疾病，且与扩张型心肌病的发生密切相关，近年来其发病率有增高趋势，严重危害患儿的身心健康，给家长和社会带来沉重负担。目前认为VM与病毒触发人体自身免疫反应而引起的心肌损害有关，治疗方面尚缺少特效高效的治疗方法，仍以营养心肌治疗为主。本院本科2005～2010年应用环磷酰胺联合免疫球蛋白治疗90例小儿病毒性心肌炎患者，取得了良好的疗效，现报道如下：
1 资料与方法
1.1 一般资料
2005年1月~2010年10月在本院儿科住院部接收病毒性心肌炎患儿185例。年龄最小4岁，最大10岁，多因胸闷、心悸，长叹气，心前区不适等症状前往门诊就诊。发病以秋季及春季为主 ......
您现在查看是摘要介绍页，详见PDF附件(1583kb)。