恶性肿瘤患者血液流变学及热休克蛋白水平变化规律研究(1)
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[摘要] 目的 探讨恶性肿瘤患者血液流变学及热休克蛋白水平的变化规律。 方法 选择2009年8月～2010年12月在本院肿瘤科住院的恶性肿瘤患者79例，同时入选健康者82例作为对照组，比较两组人群血液流变学的特点。 结果 恶性肿瘤组全血黏度、血浆黏度、血沉、红细胞压积、红细胞刚性指数、红细胞聚集指数和纤维蛋白原值均显著大于健康人群组，差异具有统计学意义，P < 0.05或0.01。79例恶性肿瘤患者中，发生转移者46例，占58.2%；未发生转移者33例，占41.8%；转移组血沉、红细胞聚集指数与未转移组差异无统计学意义，P > 0.05；转移组全血黏度、血浆黏度、红细胞压积、纤维蛋白原显著高于未转移组，P < 0.05，根据病理结果将患者分为低分化组(n = 2，占2.5%)、中分化组(n = 34，占43.0%)及高分化组(n = 43，占54.5%)。3组患者热休克蛋白阳性率分别为83.7%、67.6%、0.0，差异具有统计学意义，P < 0.05。 结论 肿瘤的恶性程度越高，其血液流变学改变越显著，热休克蛋白含量越高。
[关键词] 恶性肿瘤；血液流变学；热休克蛋白；变化规律
[中图分类号] R73 [文献标识码] A [文章编号] 1674-4721(2012)02(c)-0010-03
Research of hemorheology and heat shock protein change law in patients with m alignant tumor
GUO Jianfeng
Pangang Midi Steel Worker Hospital of Panzhihua City in Sichuan Province, Panzhihua 617063, China
[Abstract] Objective To investigate the alteration of hemorheology and heat shock protein in patient with m alignant tumors. Methods Seventy nine patients with m alignant tumors were enrolled from August 2009 to December 2010 in oncology department of our hospital, 82 health persons were also enrolled as control group. The hemorheology was analyzed in both groups. Results The whole blood viscosity, the blood plasma viscosity, the erythrocyte sedimentation rate, the red blood cell press the product, the red blood cell rigid index, the red blood cell accumulation index and the fibrinogen level of m alignant tumor patients showed significant higher than the controls, P < 0.05 or 0.01. In 79 patients with m alignant tumor patients, the shift in 46 patients, accounted for 58.2%, not the shift in 33 patients, accounted for 41.8%; Whole blood viscosity, plasma viscosity, red blood cell deposited, fibrinogen in transfer group were significantly higher than not transfer group, P < 0.05; According to pathological results, all patients with m alignant tumors were divided into poorly differentiated group (n = 2, accounted for 2.5%), moderately differentiated group (n = 34, accounted for 43.0%) and well differentiated group (n = 43, accounted for 54 ......
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