ΔNp63、VEGF和PCNA在膀胱尿路上皮癌中的表达及其与肿瘤浸润和转移的关系(1)
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[摘要] 目的 探讨ΔNp63、VEGF和PCNA蛋白在膀胱尿路上皮癌组织中的表达及其与癌浸润、转移的关系。 方法 用免疫组织化学方法检测ΔNp63、VEGF和PCNA的表达，并将三者的表达做相关性分析。 结果 ΔNp63、VEGF和PCNA在肿瘤组织中的阳性表达率分别为78.7%、58.3%和84.3%；与对照膀胱组织相比，其表达显著增高，差异均有统计学意义(P < 0.01)；且病理分级高级别、浸润性尿路上皮癌及有淋巴结转移的患者的阳性率显著高于病理分级低级别、浅表性尿路上皮癌及无淋巴结转移的患者，差异均有统计学意义 (P < 0.05)。 结论 ΔNp63、VEGF和PCNA的过表达与膀胱尿路上皮癌浸润转移相关，且三者在其浸润转移中关系密切。
[关键词] 膀胱尿路上皮癌；ΔNp63；VEGF；PCNA；免疫组化
[中图分类号] R737.14 [文献标识码] A [文章编号] 1674-4721(2012)02(c)-0012-03
The relationship of the expression of ΔNp63, VEGF and PCNA with the invasion and metastasis of transitional cell carcinoma of bladder
HE Jinghua1 GAO Fang1 ZHANG Fengmei2 ZHANG Xiubin3 XU Hua2 LI Shengshui2
1.Department of Pathology, Boai Hospital of Huanghua Development Zone in Hebei Province, Huanghua 061100, China; 2.Department of Pathology, Integrated Chinese and Western Medicine Hospital of Cangzhou in Hebei Province, Cangzhou 061000, China; 3.Department of Pathology, Nandagang Hospital in Hebei Province, Nandagang 061103, China
[Abstract] Objective To investigate the expression of ΔNp63，VEGF and PCNA in transitional cell carcinoma of bladder (TCCB) and their relationship with the invasion and metastasis of TCCB. Methods The expressions of ΔNp63，VEGF and PCNA on pathological sections of 108 patients with TCCB were detected with immunohistochemical staining. The immunoassay results were analyzed in relation to the tumor stage, grade and the clinical prognosis. Results ΔNp63, VEGF in tumor tissue of PCNA and positive expression rate were 78.7%, 58.3% and 84.3%; Compared with control bladder tissue, its expression was significantly higher, the differences were statistically significant (P < 0.01); And pathology classification high level, invasive urothelial carcinoma and a lymph node metastasis of positive patients significantly higher than the low level pathology classification, superficial urothelial carcinoma and without lymph node metastasis of the patients, the differences were statistically significant (P < 0 ......
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