环孢菌素A联合十一酸睾酮与单独十一酸睾酮治疗再生障碍性贫血的临床疗效对比(1)
 |
| 第1页 |
参见附件。
[摘要] 目的 研究环孢菌素A联合十一酸睾酮与单独运用十一酸睾酮治疗再生障碍性贫血的临床疗效。 方法 选取本院2008年9月～2010年5月收治的40例再生障碍性贫血患者，随机分为治疗组(20例)和对照组(20例)，治疗组采用研究环孢菌素A联合十一酸睾酮治疗，对照组仅采用十一酸睾酮进行治疗。 结果 治疗组和对照组的总有效率分别为85%和65%，两组差异具有统计学意义(χ2 = 4.266 7，P < 0.05)；治疗组与对照组治疗过程中不良反应的发生率分别为20%和25%，两组差异无统计学意义(χ2 = 0.286 7，P > 0.05)。 结论 环孢菌素A联合十一酸睾酮治疗再生障碍性贫血与传统疗法相比，治疗效果明显，并且能够减少治疗过程中的不良反应，值得临床推广应用。
[关键词] 环孢菌素A；十一酸睾酮；再生障碍性贫血；疗效观察
[中图分类号] R973 [文献标识码] A [文章编号] 1674-4721(2012)02(c)-0078-02
Curative effect contrast between cyclosporin A with Testosterone undecanoate and Testosterone undecanoate only in the treatment of aplastic anemia
TANG Yirong HUANG Xiujuan CHEN Qi
Blood Division of Rheumatology of Ningde City Hoapital in Fujian Province, Ningde 352100, China
[Abstract] Objective To study the curative effect contrast between cyclosporin A with Testosterone undecanoate and Testosterone undecanoate only in the treatment of aplastic anemia. Methods Forty patients with aplastic anemia were selected from September 2008 to May 2010 in our hospital, and were divided into treatment group (n = 20) and control group(n = 20), the treatment group was treated with Cyclosporin A and Testosterone undecanoate, and the control group was treated with Testosterone undecanoate only. Results The total effective rate of the contral group and the treatment group were 65% and 85%, respectively (χ2 = 4.266 7, P < 0.05). The adverse reaction of the control group and the treatment group were 25% and 20%, respectively (χ2 = 0.286 7, P > 0.05). Conclusion The method of using Cyclosporin A with Testosterone undecanoate for aplastic anemia is much more superior to the traditional method of using Testosterone undecanoate only, And it is worthy of clinical application.
[Key words] Cyclosporin A; Testosterone undecanoate; Aplastic anemia; Efficacy observation
再生障碍性贫血(aplastic anemia)是由多种病因引起的一种以造血功能障碍、脂肪髓取代红骨髓引起红骨髓容量降低，造血衰竭的，以全血细胞减少为主要临床特征的综合性疾病[1]。目前本疾病的治疗方法包括支持疗法、促进骨髓造血功能恢复以及病因学治疗等措施[2]。本研究中通过环孢菌素A联合十一酸睾酮治疗再生障碍性贫血与传统单独运用十一酸睾酮治疗相比，取得明显的临床疗效，现总结报道如下：
1 资料与方法
1.1 一般资料
选择本院2008年9月～2010年5月收治的再生障碍性贫血患者40例，其中，男22例，女18例；年龄13～60岁，平均(33.5±1 ......
您现在查看是摘要介绍页，详见PDF附件(1941kb)。