可溶性血栓调节蛋白与老年原发性高血压患者发生缺血性脑卒中的相关性研究(1)
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[摘要] 目的 探讨血浆中可溶性血栓调节蛋白(sTM)变化与老年高血压病并发缺血性脑卒中的关系，为早期干预、防治老年高血压病并发缺血性脑卒中提供理论依据。 方法 采用前瞻性研究方法，选取69例老年高血压病并发缺血性脑卒中的患者作为实验组，另选69例健康者作为对照组，采集受试者空腹肘静脉血，应用酶联免疫吸附法(ELISA)测定测定血浆中sTM的水平。 结果 治疗前实验组和对照组血浆sTM水平比较，实验组(50.21±11.56)ng/mL，对照组(13.26±2.98) ng/mL，差异有统计学意义(P < 0.05)；治疗前按照高血压分级进行t检验，三组之间差异均有统计学意义(P < 0.05)；治疗后1周、2周和3周进行比较，三组之间差异均有统计学意义(P < 0.05)。结论 检测sTM可作为老年高血压病并发缺血性脑卒中血管内皮损伤的观察指标，对防治老年高血压病并发缺血性脑卒中有重要的临床意义。
[关键词] 可溶性血栓调节蛋白；老年高血压病；缺血性脑卒中；相关性
[中图分类号] R743 [文献标识码] A [文章编号] 1674-4721(2012)03(c)-0009-03
A correlation study on soluble thrombomodulin (sTM) and old hypertension patients with ischemic stroke
ZHAO Yanling
Department of Gerontology, Central People's Hospital of Zhanjiang City in Guangdong Province, Zhanjiang 524037, China
[Abstract] Objective To explore the relation on soluble thrombomodulin (sTM) and old hypertension patients with ischemic stroke, and provide the theoretical basis for early intervention prevention and control of ischemic stroke of hypertension. Methods Prospectie study method was used, 69 cases of hypertension patients with ischemic stroke were selected as the experimental group, 69 cases of health people as the control group, fasting cubits venous blood of them were collected, ELISA method (ELISA) was for soluble thrombomodulin (sTM) level. Results Before treatment, the experimental group and control group in the plasma levels of sTM compared [(50.21±11.56) ng/mL vs (13.26±2.98) ng/mL], the difference was statistically significant (P < 0.05); patients were divided into three groups according to classification of high blood pressure, sTM of three groups were significanly different (P < 0.05). After one, two, three weeks treatment, sTM of three groups compared, the differenles were statistically significant (P < 0.05). Conclusion sTM can be used as observation index for old hypertension patients with ischemic stroke, the prevention and cure of them have important clinical significance.
[Key words] Soluble thrombomodulin; Old hypertension; Ischemic stroke; Correlation
高血压病是心血管系统发病率最高危害最大的的疾病。主要并发症是脑卒中、肾脏损伤和心肌梗死等，在我国，主要并发症是脑卒中，西方国家以冠心病为主。近年的研究发现，血管内皮细胞能够分泌多种血管活性物质，具有内分泌、旁分泌和自分泌等活跃的生理功能。内皮细胞功能紊乱可致血管舒缩异常、血小板粘附、聚集以及血栓形成等；研究还表明，内皮细胞损伤重要的标志和代表是血栓调节蛋白(TM)[1-3] ......
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