单唾液酸四己糖神经节苷脂钠治疗帕金森病的临床观察(1)
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[摘要] 目的 研究单唾液酸四己糖神经节苷脂钠(GM1)对帕金森病(PD)的治疗效果。 方法 将68例帕金森病患者按住院顺序分为实验组和对照组，各34例。两组均予美多巴等基础治疗，实验组加用GM1 100 mg，每日1次，静滴，3周为1个疗程。观察两组患者治疗前后帕金森病的有效率及其综合评分量表(UPDRS)积分。 结果 实验组有效率为47.06%，高于对照组的17.64%，两组比较差异有统计学意义(P < 0.05)。实验组患者精神、行为、日常活动评分治疗前为(3.647±1.125)分，治疗后为(2.059±0.600)分；日常活动评分治疗前为(15.059±1.922)分，治疗后为(9.441±1.727)分；运动功能评分治疗前为(18.206±2.972)分，治疗后为(11.735±3.502)分，两组精神、行为、情绪、日常活动及运动功能评分治疗前后比较，差异有统计学意义(P < 0.05)。 结论 GM1治疗帕金森病具有较显著的临床效果。
[关键词] 四己糖神经节苷脂钠；美多巴；帕金森病；疗效观察
[中图分类号] R742.5 [文献标识码] A [文章编号] 1674-4721(2012)04(a)-0080-02
Clinical observation on monosialotetrahexosylganglioside in the treatment of Parkinson's disease
HAO Yu
Department of Neurology, Taiyuan Eighth People's Hospital of Shanxi Province, Taiyuan 030001, China
[Abstract] Objective To observe the clinical efficacy of monosialotetrahexosylganglioside on Parkinson's disease(PD). Methods Sixty eight patients of PD were averagely divided into test group and control group. Both two groups were treated with Madopa and other basic treatments, beside that the test group was treated with GM1. And they were both treated for three weeks. The effective rate of PD and the improvement of scores which were evaluated by unified Parkinson's disease rating scales(UPDR) before and after treatment were observed. Results The effective rate of test group was 47.06%, and it was higher than that of the control group(17.64%) (P < 0.05). The scores of mind, behavior, emotion, before the test was (3.647±1.125)，after that was (2.059±0.600); daily activity was (15.059±1.922), and after that was (9.441±1.727), and motor function was (18.206±2.972)， after the test was (11.735±3.502), The cumulative scores of mind, behavior, emotion, daily activity and motor function in patients of test group significantly decreased after treatment (P < 0.05). Conclusion The treatment of PD patients with GM1 has definite effect.
[Key words] Monosialotetrahexosylganglioside; Madopa; Parkinson's disease; Effect observation
帕金森病(Parkinsin's Disease，PD)是一种常见的进展性神经系统变性疾病，以静止性震颤、运动迟缓、肌强直和姿势步态异常为主要特征的锥体外系疾病 ......
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