中西医结合保守治疗异位妊娠疗效观察(1)
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[摘要] 目的 探讨中药杀胚化瘀方联合米非司酮保守治疗异位妊娠的可行性、安全性及疗效。 方法 2005年7月～2011年10月本院收治的异位妊娠符合保守治疗条件的患者250例随机平均分为两组，研究组125例用中药杀胚化瘀方每日1剂口服1周，联合米非司酮50 mg口服每12小时1次，治疗3 d；对照组125例单次肌内注射甲氨喋呤(50 mg/m2)24 h后联合米非司酮口服(服法同上)。观察比较两组治疗成功率、药物毒副反应、患侧输卵管再通率及妊娠情况。 结果 两组治疗成功率无明显差异(P > 0.05)；而消化系统、骨髓造血系统并发症及肝功损害发生率，研究组明显低于对照组(P < 0.05)，患侧输卵管通畅率、宫内妊娠率研究组明显高于对照组(P < 0.05)，再次异位妊娠发生率研究组较对照组为低。 结论 中药杀胚化瘀方联合米非司酮保守治疗异位妊娠效果较好，药物毒副作用轻，输卵管再通率及宫内妊娠率高，值得在临床推广应用。
[关键词] 杀胚化瘀方；米非司酮；甲氨喋呤；异位妊娠；保守治疗
[中图分类号] R714.22 [文献标识码] A [文章编号] 1674-4721(2012)04(a)-0120-03
Clinical observation of conservative treatment of ectopic pregnancy with combination of TCM and Western medicine
GUO Xiangyun
Lunan Yankuang Chemical Fertilizer Plant Workers Hospital in Zaozhuang City of Shandong Province, Zaozhuang 277527, China
[Abstract] Objective To discuss the feasibility, safety and efficacy of traditional Chinese medicine of killing germ removing blood stasis decoction combined with Mifepristone conservative treatment of ectopic pregnancy. Methods Two hundred and fifty cases of ectopic pregnancy patients who were treated with conservative treatment from July 2005 to October 2011 in our hospital were randomly divided into two groups. 125 cases of patients in study group were given traditional Chinese medicine of killing germ removing blood stasis decoction, daily oral, dose of a week. Combined use of Mifepristone 50 mg, served 3 days; The 125 cases of patients in control group were given intramuscular injection of Methotrexate ( 50 mg/square meters ) 24 hours after combined with Mifepristone. The success rate of treatment, drug toxicity, ipsilateral fallopian tube recanalization rate and pregnancy of two groups were compared. Results Treatment success rate of two groups was not significantly different (P > 0.05); but the digestive system and bone marrow hematopoietic system complications and liver damage occurrence rate in the study group was significantly lower than the control group (P < 0 ......
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